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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

proteolytic enzyme

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Proteolytic Enzyme (1) ADAMTS (1) Aminopeptidase (1) Apoptosis (1) Biochemical Assay Reagents (2) Cathepsin (1) Deubiquitinase (1) Drug Metabolite (2) Endogenous Metabolite (7) ERK (2) Interleukin Related (2) Melatonin Receptor (2) MMP (3) Proteasome (4) Reference Standards (1) Ser/Thr Protease (2) TNF Receptor (2) Transferrin Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (4) Endocrinology (1) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: Proteolytic Enzyme Peroxidase Enzyme E1/E2/E3 Enzyme Carnosine-cleaving Enzyme Endothelin-Converting Enzyme (ECE) Angiotensin-converting Enzyme (ACE) IRE1 NEDD8-activating Enzyme IDE TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114158

Pronase E (Activity ≥ 7000 U/g) Maximum Cited Publications 61 Publications Verification Pronase (Activity ≥ 7000 U/g)	Others	Others
Pronase E (Activity ≥ 7000 U/g) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids .

HY-114158A

Pronase E (Activity ≥ 4000 U/mg) 20+ Cited Publications Pronase (Activity ≥ 4000 U/mg)	Others	Others
Pronase E (Activity ≥ 4000 U/mg) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids .

HY-P1635

Pepsin 3 Publications Verification EC 3.4.23.1	Endogenous Metabolite	Endocrinology
Pepsin is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin contributes to proteolysis of food proteins in the vertebrate stomach .

HY-O0004

Collagenase I, from Clostridium histolyticum 1 Publications Verification	MMP	Metabolic Disease
Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation.

HY-E70076

Subtilisin, bacillus licheniformis Bacillopeptidaseb	Biochemical Assay Reagents	Others
Subtilisin (Compound proteinase) (EC 3.4.21.62) is a proteolytic enzyme, isolated from Bacillus licheniformis. Subtilisin (Compound proteinase) has catalytic activity in anhydrous dimethyl formamide. Subtilisin (Compound proteinase) can be used as a catalyst for easy coupling between sugars and amino acids .

HY-E70198

Pepsin (MS Grade) 3 Publications Verification EC 3.4.23.1 (MS Grade)	Endogenous Metabolite	Others
Pepsin (MS Grade) is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin (MS Grade) contributes to proteolysis of food proteins in the vertebrate stomach .

HY-E70203

Recombinant aprotinin	Ser/Thr Protease	Cardiovascular Disease Inflammation/Immunology
Recombinant aprotinin is a serine protease inhibitor. Recombinant aprotinin can inhibit trypsin and related proteolytic enzymes .

HY-P2810

Rennin EC 3.4.23.4	Endogenous Metabolite Ser/Thr Protease	Metabolic Disease
Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production .

HY-E70005K

Collagenase (Type A, animal free)	Proteasome	Others
Collagenase (Type A, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .

HY-E70005M

Collagenase (Type C, animal free)	Proteasome	Others
Collagenase (Type C, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .

HY-115733

Cathepsin L-IN-2 1 Publications Verification (Rac)-Z-Phe-Phe-FMK	Cathepsin	Cancer
Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC₅₀ of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.

HY-136528

RA-9	Deubiquitinase Apoptosis	Cancer
RA-9 is a potent and selective proteasome-associated *deubiquitinating enzymes* (DUBs)** inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells .

HY-P11099

Cys-LT7	Transferrin Receptor	Neurological Disease Cancer
Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma .

HY-E70005L

Collagenase (Type B, animal free)	Proteasome	Others
Collagenase (Type B, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .

HY-P1488

Bradykinin (1-5)	Drug Metabolite	Cardiovascular Disease
Bradykinin (1-5) is a major stable metabolite of Bradykinin (HY-P0206), formed by the proteolytic action of angiotensin-converting enzyme (ACE) . Bradykinin (1-5) inhibits α- and γ-thrombin-induced platelet aggregation .

HY-P2935

Glutamic acid protease	Endogenous Metabolite	Others
Glutamic acid protease is a type of proteolytic enzyme containing glutamic acid residues, which mainly exists in fungi. Glutamic acid protease exerts its catalytic function through a glutamate-glutamine dyad .

HY-113440

5-Methoxytryptophol 1 Publications Verification	Melatonin Receptor ERK TNF Receptor Interleukin Related MMP Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
5-Methoxytryptophol is a 5-methoxyindole alcohol structurally homologous to Melatonin (HY-B0075). It is secreted by the mammalian pineal gland and exhibits an inverse circadian rhythm. 5-Methoxytryptophol regulates bone metabolism by activating the ERK1/2 pathway. It reduces the levels of pro-inflammatory cytokines TNF-α and IL-1β, as well as proteolytic enzymes MMP-1 and MMP-2, in serum and dental pulp tissues, thereby ameliorating acute pulpitis. 5-Methoxytryptophol induces rapid sleep in mice, while high doses cause respiratory depression and death. 5-Methoxytryptophol. 5-Methoxytryptophol can be used in studies related to acute pulpitis, hypnosis, and bone metabolism .

HY-E70231

Thrombin-like enzyme	Others	Cardiovascular Disease
Thrombin-like enzyme is a proteolytic enzyme extraction of Agkistrodon halys venom. Thrombin-like enzyme can be used for degradation of fibrinogen. Thrombin-like enzyme can exacerbate myosin-induced EAM (experimental autoimmune myositis). Thrombin-like enzyme can be used for degradation of fibrinogen. Thrombin-like enzyme is commonly used for research of acute ischemic cerebrovascular disease, thromboangiitis obliterans, deep phlebitis and sudden deafness .

HY-E70005O

Collagenase (Type A, filtered, animal free)	Proteasome	Others
Collagenase (Type A, filtered, animal free) is a proteolytic enzyme targeting collagen, capable of releasing corneal endothelial cells (CECs) without damaging cell junctions .

HY-P2919

Rennet	Endogenous Metabolite	Inflammation/Immunology
Rennet is is a mixture of the proteolytic enzymes pepsin and chymosin (rennin), which is found in the fourth stomach of young ruminants. Rennet is promising for research of allergies (e.g., asthma, rhinitis) .

HY-107940

Sutilains	Proteolytic Enzyme	Others
Sutilains is a proteolytic enzyme that dissolves necrotic tissue and hyaluronidase. Sutilains can be used as a topical debriding agent in burns .

HY-E70628

Aspartic acid proteinase	Biochemical Assay Reagents	Others
Aspartic acid proteinase is a type of proteolytic enzyme, which is characterized by its action via two critical aspartic acid residues in the active site, which facilitate the hydrolysis of peptide bonds in proteins .

HY-P1488A

Bradykinin (1-5) TFA	Drug Metabolite	Cardiovascular Disease
Bradykinin (1-5) (TFA) is a major stable metabolite of Bradykinin (HY-P0206), formed by the proteolytic action of angiotensin-converting enzyme (ACE). Bradykinin (1-5) (TFA) inhibits α- and γ-thrombin-induced platelet aggregation .

HY-E70964A

Leucine Aminopeptidase, Porcine	Aminopeptidase	Metabolic Disease
Leucine Aminopeptidase, Porcine (EC 3.4.11.1) is a proteolytic enzyme which hydrolyzes the peptide bond adjacent to a free amino group. Leucine Aminopeptidase, Porcine (EC 3.4.11.1) rapidly catalyzes the hydrolysis of leucine containing peptides and also catalyzes the hydrolytic release of other amino acids located at the N-terminal end of various peptides and proteins.

HY-P992336

CRB0017	ADAMTS	Inflammation/Immunology
CRB0017 is a recombinant monoclonal antibody targeting ADAMTS5, with high affinity for the spacer domain of ADAMTS5 and strong antigen specificity. CRB0017 binds to the spacer domain of ADAMTS5 and reduces the proteolytic activity of this enzyme. CRB0017 delays articular cartilage degradation, alleviates the pathological severity of osteoarthritis, and decreases the osteoarthritis histopathological score. CRB0017 is applicable to the research of osteoarthritis .

HY-113440R

5-Methoxytryptophol (Standard)	Reference Standards Interleukin Related Endogenous Metabolite Melatonin Receptor TNF Receptor ERK MMP	Neurological Disease Metabolic Disease Inflammation/Immunology
5-Methoxytryptophol (Standard) is the analytical standard of 5-Methoxytryptophol. This product is intended for research and analytical applications. 5-Methoxytryptophol is a 5-methoxyindole alcohol structurally homologous to Melatonin (HY-B0075). It is secreted by the mammalian pineal gland and exhibits an inverse circadian rhythm. 5-Methoxytryptophol regulates bone metabolism by activating the ERK1/2 pathway. It reduces the levels of pro-inflammatory cytokines TNF-α and IL-1β, as well as proteolytic enzymes MMP-1 and MMP-2, in serum and dental pulp tissues, thereby ameliorating acute pulpitis. 5-Methoxytryptophol induces rapid sleep in mice, while high doses cause respiratory depression and death. 5-Methoxytryptophol. 5-Methoxytryptophol can be used in studies related to acute pulpitis, hypnosis, and bone metabolism.

Cat. No.	Product Name

HY-L147

Protease Inhibitor Library	927 compounds
A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. Proteases play important roles in regulating multiple biological processes in all living organisms, such as regulating the fate, localization, and activity of many proteins, modulating protein-protein interactions, creating new bioactive molecules, contributing to the processing of cellular information, and generating, transducing, and amplifying molecular signals. Proteases are important targets in drug discovery. Some protease inhibitors are often used as anti-virus drugs and anti-cancer drugs. MCE offers a unique collection of 927 protease inhibitors. MCE Protease Inhibitor Library is critical for drug discovery and development.

Protease Inhibitor Library

927 compounds

A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. Proteases play important roles in regulating multiple biological processes in all living organisms, such as regulating the fate, localization, and activity of many proteins, modulating protein-protein interactions, creating new bioactive molecules, contributing to the processing of cellular information, and generating, transducing, and amplifying molecular signals.

Proteases are important targets in drug discovery. Some protease inhibitors are often used as anti-virus drugs and anti-cancer drugs. MCE offers a unique collection of 927 protease inhibitors. MCE Protease Inhibitor Library is critical for drug discovery and development.

Cat. No.	Product Name	Target	Research Area