23815-89-6
Chemical Structure
Bradykinin (1-5)
- CAS No.: 23815-89-6
- Formula:C27H40N8O6
- Molecular Weight:572.66
IUPAC Name: L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanine
InChIKey: USSUMSBPLJWFSZ-TUFLPTIASA-N
SMILES: O=C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Biological Activity: Bradykinin (1-5) is a metabolite of Bradykinin (HY-P0206) and a PAR inhibitor that inhibits thrombin-induced platelet aggregation by preventing protease-activated receptor (Protease Activated Receptor) cleavage and inhibiting Thrombin (MW 37kDa) (HY-114164). Bradykinin (1-5) is used in research on thrombosis, carrageenan-induced pleurisy, nasal allergy, and hereditary angioedema[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bradykinin (1-5) | 99.46% | Bradykinin (1-5) is a metabolite of Bradykinin (HY-P0206) and a PAR inhibitor that inhibits thrombin-induced platelet aggregation by preventing protease-activated receptor (Protease Activated Receptor) cleavage and inhibiting Thrombin (MW 37kDa) (HY-114164). Bradykinin (1-5) is used in research on thrombosis, carrageenan-induced pleurisy, nasal allergy, and hereditary angioedema. | ||||||||||||||||||||
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References
- [1]. Murphey LJ, et al. Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. The Journal of pharmacology and experimental therapeutics. 2006 Sep;318(3):1287-92. [Content Brief]
- [2]. Voronina L, et al. Conformations of Prolyl-Peptide Bonds in the Bradykinin 1-5 Fragment in Solution and in the Gas Phase. Journal of the American Chemical Society. 2016 Jul 27;138(29):9224-33.
- [3]. Majima M, et al. Determination of bradykinin-(1-5) in inflammatory exudate by a new ELISA as a reliable indicator of bradykinin generation. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 1996 Aug;45(8):416-23.
- [4]. Seip KF, et al. Bradykinin analysis revived--a validated method for determination of its stable metabolite in whole blood by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Feb 01;947-948:139-44.
