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Results for "

quadruplex

" in MedChemExpress (MCE) Product Catalog:

By Targets:	G-quadruplex (39) ADC Payload (1) Antibiotic (1) Apoptosis (13) Atg8/LC3 (1) Autophagy (3) Bcl-2 Family (3) Biochemical Assay Reagents (2) c-Met/HGFR (1) c-Myc (10) Caspase (2) Cholinesterase (ChE) (1) CMV (2) Cyclic GMP-AMP Synthase (1) DNA Stain (1) DNA/RNA Synthesis (17) Drug Derivative (2) Drug Intermediate (1) Endogenous Metabolite (1) Environmental Pollutants (1) Ferroptosis (2) Flavivirus (3) Fluorescent Dye (1) HIF/HIF Prolyl-Hydroxylase (1) Keap1-Nrf2 (1) KLF (1) Mitochondrial Metabolism (1) Mitosis (1) Ras (3) Reactive Oxygen Species (ROS) (2) Reference Standards (1) SARS-CoV (1) Src (3) STING (1) Telomerase (8) VEGFR (2) Virus Protease (3) Wnt (1)
By Research Areas:	Cancer (54) Infection (1) Inflammation/Immunology (3) Neurological Disease (5)
Oligonucleotides:	Aptamers (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Oligonucleotides

GMP Molecules

Targets Recommended: G-quadruplex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15594A

Phen-DC3 Trifluoromethanesulfonate 5+ Cited Publications Phen-DC3 Triflate	G-quadruplex	Cancer
Phen-DC3 Trifluoromethanesulfonate is a *G-quadruplex* (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-112680A

Carboxy pyridostatin trifluoroacetate salt 5 Publications Verification	G-quadruplex	Neurological Disease
Carboxy pyridostatin trifluoroacetate salt is a *G-quadruplex* ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation .

HY-108477

TMPyP4 tosylate 5+ Cited Publications TMP 1363	G-quadruplex Telomerase Cholinesterase (ChE) SARS-CoV	Cancer
TMPyP4 tosylate (TMP 1363) is a *quadruplex*-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2 .

HY-133821

N-Methylmesoporphyrin IX 5 Publications Verification	G-quadruplex	Neurological Disease
N-Methylmesoporphyrin IX (NMM), a widely used *G-quadruplex* DNA** specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies .

HY-15176A

Pyridostatin hydrochloride Maximum Cited Publications 34 Publications Verification RR82 hydrochloride	DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease	Cancer
Pyridostatin (RR82) hydrochloride is a *G-quadruplex* DNA stabilizing agent (K_d**=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin hydrochloride promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin hydrochloride targets the proto-oncogene Src. Pyridostatin hydrochloride reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells .

HY-15176

Pyridostatin RR82	G-quadruplex	Cancer
Pyridostatin (RR82) is a *G-quadruplex* DNA stabilizing agent (K_d**=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells .

HY-16291

APTO-253 20+ Cited Publications LOR-253; LT-253	c-Myc KLF Apoptosis	Inflammation/Immunology Cancer
APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor . APTO-253 has antiarthritic activity .

HY-15794

Nemorubicin 1 Publications Verification Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243	G-quadruplex	Cancer
Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for *G-quadruplex* DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .

HY-164421

PhpC	G-quadruplex DNA/RNA Synthesis	Cancer
PhpC is a *G-quadruplex* (G4)-DNA/RNA** disruptor. PhpC disrupts DNA and RNA G4 structures and promotes G4 helicase activity. PhpC effectively enhancing the activity of Taq polymerase. PhpC modulates G-quadruplexs (G4s) both in vitro and in cells .

HY-15176B

Pyridostatin TFA Maximum Cited Publications 34 Publications Verification RR82 TFA	DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease	Cancer
Pyridostatin (RR82) TFA is a G-quadruplex (G4) inducer/stabilizer with a K_d of 490 nM. Pyridostatin TFA also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 11.0 μM. Pyridostatin TFA interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin TFA exhibits antiproliferative and antiviral activities. Pyridostatin TFA can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .

HY-15523

Braco-19 5 Publications Verification	CMV DNA/RNA Synthesis G-quadruplex	Cancer
Braco-19 is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor .

HY-148012

SOP1812 QN-302	G-quadruplex	Cancer
SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer .

HY-14776

Quarfloxin 5+ Cited Publications CX-3543	DNA/RNA Synthesis	Cancer
Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC₅₀ values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template .

HY-135009

2-Di-1-ASP DASPI	G-quadruplex	Others
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .

HY-15595A

360A iodide 3 Publications Verification 360 A iodide	G-quadruplex Telomerase	Cancer
360A iodide is a selective stabilizer of *G-quadruplex, and also inhibits telomerase* activity with an IC₅₀ of 300 nM for telomerase in TRAP-G4 assay.

HY-15176C

Pyridostatin trihydrochloride Maximum Cited Publications 34 Publications Verification RR82 trihydrochloride	DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease	Cancer
Pyridostatin (RR82) trihydrochloride is a G-quadruplex (G4) inducer/stabilizer with a K_d of 490 nM. Pyridostatin trihydrochloride also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 11.0 μM. Pyridostatin trihydrochloride interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin trihydrochloride exhibits antiproliferative and antiviral activities. Pyridostatin trihydrochloride can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .

HY-15523A

Braco-19 trihydrochloride 5 Publications Verification	DNA/RNA Synthesis CMV	Infection Cancer
Braco-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor .

HY-147652

*G-quadruplex* DNA fluorescence probe 1**	DNA Stain	Others
G-quadruplex DNA fluorescence probe 1 (Compound E1) is a selective *G-quadruplex* DNA** targeting fluorescent probe. G-quadruplex DNA fluorescence probe 1 can pass through membrane and enter living cells with low cytotoxicity .

HY-112680

Carboxypyridostatin	G-quadruplex	Neurological Disease
Carboxypyridostatin is a *G-quadruplex* ligand. Carboxypyridostatin has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxypyridostatin reduces cell proliferation and hinders stress granule (SG) formation .

HY-156228

RGB-1	Ras	Cancer
RGB-1 selectively binds to and stabilizes RNA G-quadruplex structures, and reduces the expression of the NRAS proto-oncogene in breast cancer cells. RGB-1 can serve as a tool for investigating the cellular functions of RNA G-quadruplex structures and identifying novel mRNA G-quadruplex-forming sequences. RGB-1 is applicable for breast cancer research .

HY-135776

BMVC2 o-BMVC	G-quadruplex	Cancer
BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a *G-quadruplex* (G4)** stabilizer .

HY-148953

MTR-106	G-quadruplex DNA/RNA Synthesis Apoptosis	Cancer
MTR-106 is a potent and orally active *G-quadruplex* stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer .

HY-135775

BMVC 1 Publications Verification	G-quadruplex Telomerase DNA/RNA Synthesis	Cancer
BMVC is a potent *G-quadruplex* (G4) stabilizer and a selective telomerase inhibitor with an IC₅₀ of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC₅₀** of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities .

HY-157417

*G-quadruplex* ligand 1**	DNA/RNA Synthesis	Others
G-quadruplex ligand 1, a *G-quadruplex* ligand, disrupts G-Quadruplex DNA structure and enhances gene expression .

HY-145748

SYUIQ-5	G-quadruplex Autophagy c-Myc	Cancer
SYUIQ-5 is a *G-quadruplex* ligand. SYUIQ-5 stabilizes G-quadruplex and induce senescence. SYUIQ-5 inhibits c-myc gene promoter activity. SYUIQ-5 induces cancer cells autophagy by triggering telomere damage through TRF2 delocalization from telomeres .

HY-15595

360A	G-quadruplex Telomerase	Cancer
360A is a selective stabilizer of *G-quadruplex, and also inhibits telomerase* activity with an IC₅₀ of 300 nM for telomerase in TRAP-G4 assay.

HY-W543137

PT-ttpy	G-quadruplex DNA/RNA Synthesis Mitosis	Cancer
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

HY-16967

MM41	G-quadruplex Bcl-2 Family Ras Caspase	Cancer
MM41 is a *quadruplex*-interacting compound. MM41 binds tightly to quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. MM41 reduces BCL-2 and k-RAS protein levels, increases caspase 3. MM41 has antitumor effects against pancreatic cancer .

HY-DY1075

N-Methylmesoporphyrin IX (solution)	G-quadruplex	Neurological Disease
N-Methylmesoporphyrin IX (NMM) (solution) , a widely used *G-quadruplex* DNA** specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies . Solvent and concentration: DMSO: 2 mM

HY-W004769

Benzo[h]quinoline α-Naphthoquinoline	Environmental Pollutants Drug Intermediate	Others
Benzo[h]quinolone is a widespread environmental pollutant. Benzo[h]quinolone is mutagenic. Benzo(h)quinoline derivatives can serve as *G-quadruplex* binding agents .

HY-15594

Phen-DC3	DNA/RNA Synthesis	Cancer
Phen-DC3 is a *G-quadruplex* (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-148200

L2H2-6OTD	ADC Payload Telomerase	Cancer
L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC₅₀ value of 15 nM .

HY-101931

hVEGF-IN-1	VEGFR	Cancer
hVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a K_d of 0.928 μM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression .

HY-144712

L5-DA	G-quadruplex Apoptosis	Cancer
L5-DA is a *G-quadruplex* (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC₅₀=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis**, and cell cycle arrest .

HY-178909

Y502-2304	c-Myc Apoptosis Reactive Oxygen Species (ROS)	Cancer
Y502-2304 is a c-Myc G-quadruplex stabilizer. Y502-2304 exhibits potent antiproliferative activity in multiple myeloma (MM) cells. Y502–2304 downregulates c-Myc mRNA and protein expression. Y502-2304 induces apoptosis in MM cells, characterizes by elevated γH2AX levels, increases reactive oxygen species (ROS) generation, and mitochondrial dysfunction. Y502-2304 significantly inhibits tumor growth in a xenograft MM model. Y502-2304 can be used for the study of multiple myeloma .

HY-152538

Antitumor agent-85	G-quadruplex	Cancer
Antitumor agent-85 is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-85 has highly effective anti-tumor properties .

HY-161693

Telomeric G4s ligand 1	G-quadruplex DNA/RNA Synthesis Apoptosis	Cancer
Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells .

HY-145843

c-Myc inhibitor 5	c-Myc	Cancer
c-Myc inhibitor 5 (DA3) is a fluorescent, long chain-bridged bispurine that selectively targets the c-MYC G-quadruplex (K_D of 16 μM). c-Myc inhibitor 5 shows inhibition on c-MYC expression rather than other G4-driven oncogenes .

HY-177872

GQC-05 NSC 338258	Drug Derivative c-Myc Apoptosis	Cancer
GQC-05 (NSC338258), Ellipticine (HY-15753) derivative, is potent and selective c-Myc G-quadruplex ( c-Myc G4) stabilizer with K_D values of 0.1-1.43 μM. GQC-05 can reduce Myc expression and induce cancer cells apoptosis. GQC-05 can be used for the research of cancer, such as Burkitt lymphoma .

HY-174384

MET Transcription-IN-1	c-Met/HGFR Apoptosis G-quadruplex	Cancer
MET Transcription-IN-1 (Compound C3) is an orally active MET transcription inhibitor. MET Transcription-IN-1 can efficiently bind and stabilize the G-quadruplex in the MET promoter region, thereby inhibiting c-Met expression. MET Transcription-IN-1 can also overcome drug resistance caused by specific c-Met mutations. MET Transcription-IN-1 is capable of inhibiting tumor cell proliferation, migration, and invasion, as well as inducing cell cycle arrest and apoptosis. MET Transcription-IN-1 has antitumor activity, and can be used in the research of tumors such as non-small cell lung cancer .

HY-170814

*G-quadruplex* ligand 3**	G-quadruplex	Cancer
G-quadruplex ligand 3 (Compound 16) is a *G-quadruplex* ligand with anticancer effects that chelate iron. G-quadruplex ligand 3 stabilizes G-quadruplexes in human leukemia Jurkat cells. G-quadruplex ligand 3 localizes in the cell nucleus, serving as a fluorescent nuclear tracer for the labile iron pool .

HY-158126

*G-quadruplex* ligand 2**	DNA/RNA Synthesis	Cancer
G-quadruplex ligand 2 (compound A3) is a triphenylamine-based ligand that targets mitochondrial DNA G4s. G-quadruplex ligand 2 activates the cGAS-STING pathway. G-quadruplex ligand 2 inhibits tumor growth and metastasis via regulation of TME .

HY-D2380

H2S probe 1	G-quadruplex	Cancer
H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC₅₀=77.9 nM) and has a high affinity for human telomeric *G-quadruplex* (G4) (K_d=1.72 μM). H2S probe 1 can be used in cancer research .

HY-15794A

Nemorubicin hydrochloride Methoxymorpholinyl doxorubicin hydrochloride; FCE 23762 hydrochloride; PNU 152243A	G-quadruplex	Cancer
Nemorubicin hydrochloride is a derivative of doxorubicin, and has antitumor activity. Nemorubicin hydrochloride, not only intercalate into the duplex DNA, but also result in significant ligands for *G-quadruplex* DNA segments, stabilizing their structure.

HY-120750

A 62176 hydrochloride	Endogenous Metabolite	Cancer
A 62176 hydrochloride is a compound that targets DNA topoisomerase II and has the activity of inhibiting purine synthesis in cancer cells. A 62176 hydrochloride interferes with c-MYC mRNA expression by interacting with G-quadruplex. The main mechanism of action of A 62176 hydrochloride is by displacing nucleosomes from the quadruplex of non-template strand rDNA, resulting in rapid redistribution of nucleosomes. The application potential of A 62176 hydrochloride is that it causes DNA damage and relies on BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways to repair the damage .

HY-117479

CL67	HIF/HIF Prolyl-Hydroxylase	Cancer
CL67 is a potent hypoxia-inducible factor (HIF) pathway inhibitor. CL67 interferes G-quadruplex structures within promoter sequences. CL67 can be used in research of renal cancer .

HY-151471

Anticancer agent 84	c-Myc	Cancer
Anticancer agent 84 is an anticancer agent. Anticancer agent 84 represses the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure. Anticancer agent 84 can be used for the research of cancer .

HY-164528

SJ26	Wnt G-quadruplex	Cancer
SJ26 is a Wnt1 inhibitor with anticancer activity. SJ26 inhibits the expression of Wnt1 and Wnt1-mediated downstream signaling pathways in a *G-quadruplex* structure-dependent manner to suppress the migration activity of cancer cells .

HY-152537

Antitumor agent-84	G-quadruplex	Cancer
Antitumor agent-84 (compound 21a) is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-84 has highly effective anti-tumor properties .

HY-148200A

L2H2-6OTD diformic	Telomerase	Cancer
L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomere inhibitor analog. L2H2-6OTD acetate has telomerase inhibitory activity with an IC₅₀ value of 15 nM .

Cat. No.	Product Name	Type

HY-133821

N-Methylmesoporphyrin IX

5 Publications Verification

Fluorescent Dye

N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies .

HY-135009

2-Di-1-ASP DASPI	Fluorescent Dye
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .

HY-DY1075

N-Methylmesoporphyrin IX (solution)

Fluorescent Dye

N-Methylmesoporphyrin IX (NMM) (solution) , a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies .
Solvent and concentration: DMSO: 2 mM

HY-D2380

H2S probe 1	Fluorescent Dye
H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC₅₀=77.9 nM) and has a high affinity for human telomeric *G-quadruplex* (G4) (K_d=1.72 μM). H2S probe 1 can be used in cancer research .

HY-15794G

Nemorubicin

Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243

Fluorescent Dye

Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .

HY-D3415

TOR-G4

Fluorescent Dye

TOR-G4 is a Fluorescent probe that binds to G-quadruplex (G4) nucleic acid structures. TOR-G4 exhibits a unique fluorescence lifetime when bound to G4 compared to other structures, enabling sensitive discrimination between G4-bound and non-G4-bound states. TOR-G4 mainly colocalizes with RNA in the cytoplasm and nucleolus. TOR-G4 can be used to investigate the roles of RNA G4 in cells. TOR-G4 shows cytotoxicity against osteosarcoma cells .

Cat. No.	Product Name	Type

HY-W543137

PT-ttpy	Biochemical Assay Reagents
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

HY-15794G

Nemorubicin

Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243

Biochemical Assay Reagents

HY-161547

Tetracycline/BSA	Biochemical Assay Reagents
Tetracycline/BSA is a tetracycline-carrier protein conjugate of Tetracycline (HY-A0107) and bovine serum albumin (BSA). Tetracycline/BSA can be used as an immobilized capture antigen for the detection of tetracycline residues in milk .

Cat. No.	Product Name		Classification

HY-147081B

AS 1411 triethylamine AGRO-100 triethylamine		Aptamers
AS1411 (AGRO-100) triethylamine is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. AS1411 triethylamine has anti-tumor activity.

Targets Recommended: G-quadruplex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15794G

Nemorubicin Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243	G-quadruplex	Cancer
Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for *G-quadruplex* DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .

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