1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Quarfloxin

Quarfloxin (Synonyms: CX-3543)

Cat. No.: HY-14776 Purity: 99.93%
Handling Instructions

Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.

For research use only. We do not sell to patients.

Quarfloxin Chemical Structure

Quarfloxin Chemical Structure

CAS No. : 865311-47-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 466 In-stock
Estimated Time of Arrival: December 31
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1].

IC50 & Target

RNA pol I[1].

In Vitro

Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1]. Solution in vitro: Quarfloxin is resuspended in DMSO to a stock of 10 mM[1].

Clinical Trial
Molecular Weight

604.67

Formula

C₃₅H₃₃FN₆O₃

CAS No.

865311-47-3

SMILES

O=C(C1=CN2C3=C(C(N4CC(C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[[email protected]]8N(C)CCC8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (8.27 mM; ultrasonic and adjust pH to 3 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6538 mL 8.2690 mL 16.5379 mL
5 mM 0.3308 mL 1.6538 mL 3.3076 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.93%

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Keywords:

QuarfloxinCX-3543CX3543CX 3543DNA/RNA SynthesisInhibitorinhibitorinhibit

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Quarfloxin
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