1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Quarfloxin

Quarfloxin (Synonyms: CX 3543)

Cat. No.: HY-14776
Handling Instructions

Quarfloxin (CX 3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.

For research use only. We do not sell to patients.

Quarfloxin Chemical Structure

Quarfloxin Chemical Structure

CAS No. : 783364-52-3

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Description

Quarfloxin (CX 3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1].

IC50 & Target

RNA pol I[1].

In Vitro

Quarfloxin (CX 3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

604.67

Formula

C₃₅H₃₃FN₆O₃

CAS No.

783364-52-3

SMILES

FC1=C(N2CC[[email protected]](C3=NC=CN=C3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[[email protected]]7N(C)CCC7)=O)C8=O)C8=C1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Quarfloxin
Cat. No.:
HY-14776
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Quarfloxin

Cat. No.: HY-14776