865311-47-3
Chemical Structure
Quarfloxin
Synonym(s): CX-3543
- CAS No.: 865311-47-3
- Formula:C35H33FN6O3
- Molecular Weight:604.67
IUPAC Name: 5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-(3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
InChIKey: WOQIDNWTQOYDLF-CGAIIQECSA-N
SMILES: O=C(C1=CN2C3=C(C(N4CC(C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
Biological Activity: Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Quarfloxin | 99.87% | Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template. | ||||||||||||||||||||
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