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Results for "

rabbit platelets

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (2) Autophagy (4) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (2) COX (3) Dopamine Receptor (1) Drug Derivative (2) Drug Metabolite (1) Endogenous Metabolite (1) Factor Xa (2) Histamine Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (2) Kallikrein (2) Keap1-Nrf2 (1) Leukotriene Receptor (2) Lipoxygenase (1) Monoamine Transporter (1) P-glycoprotein (1) P2Y Receptor (3) Parasite (1) PDGFR (1) PGE synthase (1) Phosphodiesterase (PDE) (1) Platelet-activating Factor Receptor (PAFR) (18) Prostaglandin Receptor (6) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Ser/Thr Protease (2) Serotonin Transporter (3) Thrombin (4) TNF Receptor (1) UGT (1) α-synuclein (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (33) Infection (3) Inflammation/Immunology (16) Neurological Disease (8)

By Targets:

Adenylate Cyclase (2)

Autophagy (4)

Bacterial (1)

Biochemical Assay Reagents (1)

Calcium Channel (2)

COX (3)

Dopamine Receptor (1)

Drug Derivative (2)

Drug Metabolite (1)

Endogenous Metabolite (1)

Factor Xa (2)

Histamine Receptor (1)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

Kallikrein (2)

Keap1-Nrf2 (1)

Leukotriene Receptor (2)

Lipoxygenase (1)

Monoamine Transporter (1)

P-glycoprotein (1)

P2Y Receptor (3)

Parasite (1)

PDGFR (1)

PGE synthase (1)

Phosphodiesterase (PDE) (1)

Platelet-activating Factor Receptor (PAFR) (18)

Prostaglandin Receptor (6)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

Ser/Thr Protease (2)

Serotonin Transporter (3)

Thrombin (4)

TNF Receptor (1)

UGT (1)

α-synuclein (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (33)

Infection (3)

Inflammation/Immunology (16)

Neurological Disease (8)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1287

Citalopram hydrobromide Maximum Cited Publications 9 Publications Verification (±)-Citalopram hydrobromide; Lu 10-171	Serotonin Transporter Autophagy	Neurological Disease Cancer
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI), with blood-brain barrier permeability. Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

HY-101054

NQ301 1 Publications Verification	Thrombin	Cardiovascular Disease
NQ301 is an antithrombotic agent; inhibits collagen-challenged rabbit platelet aggregation with an IC₅₀ of 10 mg/mL.

HY-122958

Peucedanocoumarin III	α-synuclein	Neurological Disease
Peucedanocoumarin III is an α-synuclein fiber depolymerizer with blood-brain barrier permeability. Peucedanocoumarin III depolymerizes β-sheet aggregate structures, promotes aggregate clearance, inhibits β23-induced cytotoxicity, blocks the formation of Lewy body-like inclusions, and prevents dopaminergic neuron loss. Peucedanocoumarin III can be used in studies related to Parkinson's disease .

HY-B1016

Trapidil AR-12008	PDGFR Phosphodiesterase (PDE) Prostaglandin Receptor	Cardiovascular Disease Neurological Disease
Trapidil (AR-12008) is an orally active vasodilator and antiplatelet agent. Trapidil antagonizes platelet-derived growth factor (PDGF), inhibits phosphodiesterase, thromboxane A₂ synthesis and pro-inflammatory cytokine production. Trapidil promotes prostacyclin biosynthesis, reduces lipid peroxidation, regulates nitric oxide metabolism, and inhibits cell proliferation and migration. Trapidil exerts tissue-protective effects, regulates bone turnover, and inhibits pyroptosis via the GPX3/Nrf2 pathway. Trapidil is applicable to research related to renal ischemia-reperfusion injury, chronic stable angina, restenosis, meningioma, diabetic cardiomyopathy and peripheral nerve crush injury .

HY-109897

CV-6209	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC₅₀s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats .

HY-B0590A

Tetrabenazine Racemate Ro 1-9569 Racemate	Monoamine Transporter Dopamine Receptor	Neurological Disease
Tetrabenazine (Ro 1-9569) Racemate is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine Racemate binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine Racemate weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine Racemate can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

HY-111247

Ro 09-0680	Others	Cardiovascular Disease
Ro 09-0680 is a potent inhibitor of rabbit platelet aggregation induced by Collagen with an IC₅₀ of 6.6 μM .

HY-128694

Foropafant SR27417	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a K_i value of 57 pM for [ ³H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets .

HY-19121A

TCV-309 chloride	Platelet-activating Factor Receptor (PAFR)	Cancer
TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC₅₀ values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock .

HY-108565

BMY 45778	Adenylate Cyclase Prostaglandin Receptor	Cardiovascular Disease
BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC₅₀ = 35 nM), rabbit (IC₅₀: 136 nM) and rat (IC₅₀ : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor .

HY-149454

P2Y1/P2Y12 antagonist-1 1 Publications Verification	P2Y Receptor	Cancer
P2Y1/P2Y12 antagonist-1 (compound 24w) is an orally available dual inhibitor of P2Y1 and P2Y12 with antiplatelet activity. P2Y1/P2Y12 antagonist-1 inhibits ADP-induced platelet aggregation in rabbit plasma with an IC₅₀ of 4.23 μM. P2Y1/P2Y12 antagonist-1 exhibits potent inhibitory effects in rat thrombosis model.

HY-N4267

Yangambin	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related	Cardiovascular Disease Infection Inflammation/Immunology
Yangambin is a PAF receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-101833

YM-264	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes.

HY-108908A

Modipafant UK-80067	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505 .

HY-Y1094

[Rh(cod)Cl]2 Chloro(1,5-cyclooctadiene)rhodium(I) dimer	Biochemical Assay Reagents	Cardiovascular Disease
[Rh(cod)Cl]2 (Chloro(1,5-cyclooctadiene)rhodium(I) dimer) is a rhodium (I) organometallic dimer complex. [Rh(cod)Cl]2 can inhibit platelet-activating factor-mediated platelet aggregation with IC₅₀ values of 5.2 and 43.3 μM in washed rabbit platelets and human platelet-rich plasmas. [Rh(cod)Cl]2 also can inhibit thrombin-, ADP (HY-W010918)- and collagen-induced aggregation with IC₅₀ values of 16.7, 162 and 69.8 μM. [Rh(cod)Cl]2 can be used for the research of cardiovascular disease, such as thrombosis .

HY-N8218

Homoeriodictyol 7-O-β-D-glucoside	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Homoeriodictyol 7-O-β-D-glucoside is a natural platelet-activating factor (PAF) antagonist. Homoeriodictyol 7-O-β-D-glucoside inhibits human and rabbit platelet aggregation induced by PAF, with an IC₅₀ of 0.8 μM .

HY-N12995

α-Bulnesene	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
α-Bulnesene is a novel PAF receptor antagonist with the IC₅₀ of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation .

HY-N1210

Spiramine A Spiramine C acetate (ester)	Bacterial	Cancer
Spiramine A (Spiramine C acetate (ester)) is a diterpene alkaloid with antitumor and antimicrobial activity. Spiramine A inhibits PAF-induced rabbit platelet aggregation in a concentration-dependent manner, with an IC₅₀ vallue of 6.7 μM .

HY-120612

BMS-884775	P2Y Receptor	Cardiovascular Disease
BMS-884775 is a selective and orally active P2Y1 antagonist with an IC₅₀ of 0.1 nM for the human P2Y1 receptor. BMS-884775 has a similar efficacy in preventing arterial thrombosis to Clopidogrel (HY-15283) and Prasugrel (HY-15284), but treatment with BMS-884775 results in shorter bleeding time and lower bleeding risk. BMS-884775 can be used in research related to antiplatelet and arterial thrombosis-associated diseases .

HY-175675

P2Y1 antagonist 4	P2Y Receptor Keap1-Nrf2	Cardiovascular Disease Neurological Disease
P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca ²⁺ increase (IC₅₀ = 1.95 μM) and platelet aggregation (IC₅₀ = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction .

HY-124887

L 651142	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
L 651142 is a weak platelet activating factor (PAF) receptor antagonist. L 651142 inhibits the binding of [ ³H]PAF to rabbit platelet, human platelet or human lung membranes with K_is of 0.839 μM, 1.82 μM, 3.64 μM, respectively .

HY-163101

CP-96021	Platelet-activating Factor Receptor (PAFR) Leukotriene Receptor	Inflammation/Immunology
CP-96021 is an orally active dual leukotriene D4 (LTD4) and platelet activating factor (PAF) receptor antagonist, featuring a guinea pig LTD4 receptor K_i of 34 nM and a rabbit PAF receptor K_i of 37 nM. CP-96021 blocks ligand binding to its target receptors, inhibits ligand-induced bronchoconstriction, and inhibits antigen-triggered airway obstructive effects. CP-96021 can be used for the research of asthma .

HY-100125

Timegadine SR1368	COX	Inflammation/Immunology
Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC₅₀s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.

HY-111766

YD-3	Thrombin	Cardiovascular Disease
YD-3 is a platelet activation inhibitor. YD-3 inhibits Thrombine-induced rabbit platelets aggregation (IC₅₀: 28.3 μM) and phosphoinositol production. In addition, YD-3 also inhibits Trypsin-induced platelet aggregation in human and rabbit with the IC₅₀ of 38.1 μM and 5.7 μM, respectively, but does not affect the proteolytic activity of trypsin .

HY-100125A

Timegadine hydrochloride SR1368 hydrochloride	COX	Inflammation/Immunology
Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine (HY-100125). Timegadine hydrochloride is an orally active inhibitor for COX and lipo-oxygenase, that inhibits COX in washed rabbit platelets and rat brain with IC₅₀ of 5 nM and 20 μM, inhibits lipo-oxygenase in in horse and washed rabbit platelets with IC₅₀ of 100 μM. Timegadine hydrochloride exhibits anti-arthritis activity .

HY-N11932

Piperulin A	Platelet-activating Factor Receptor (PAFR)	Cancer
Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC₅₀ of 7.3 μM .

HY-19126

CL-184005	Platelet-activating Factor Receptor (PAFR)	Infection Cardiovascular Disease
CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC₅₀ of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis .

HY-N12070

11-O-β-D-glucopyranosyl thamnosmonin	Others	Cardiovascular Disease
11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP .

HY-13511AS

Rupatadine-d4 fumarate UR-12592 D4 fumarate	Isotope-Labeled Compounds Histamine Receptor Autophagy	Inflammation/Immunology
Rupatadine-d₄ fumarate is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with K_i values of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes) .

HY-P3006

Des-Leu10-angiotensin I	Drug Metabolite	Cardiovascular Disease
Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a K_i value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell .

HY-106837

Israpafant Y 24180	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC₅₀s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca ²⁺ influx and intracellular Ca ²⁺ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice .

HY-106394

TP-9201	P-glycoprotein	Cardiovascular Disease
TP-9201 is a platelet glycoprotein (GP) IIb/IIIa receptor antagonist. TP-9201 inhibits the interaction between GPIIb/IIIa and fibrinogen, thereby suppressing platelet aggregation. TP-9201 exhibits similar inhibitory activity on adenosine diphosphate (ADP) (HY-W010918)-induced platelet aggregation in humans, baboons, and dogs (IC₅₀ = 1-3 μM), while showing lower activity in rabbits (IC₅₀ = 45 μM) and rats (IC₅₀ = 20 μM). TP-9201can be used in studies related to the prevention of rethrombosis after arterial thrombolysis .

HY-114846

Ro 22-9194	Prostaglandin Receptor	Cardiovascular Disease
Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action .

HY-B1287R

Citalopram hydrobromide (Standard) 5+ Cited Publications (±)-Citalopram hydrobromide(Standard); Lu 10-171 (Standard)	Reference Standards Serotonin Transporter Autophagy	Neurological Disease Cancer
Citalopram (hydrobromide) (Standard) is the analytical standard of Citalopram (hydrobromide). This product is intended for research and analytical applications. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

HY-B1287S

Citalopram-d3 hydrobromide (±)-Citalopram hydrobromide-d₃; Lu 10-171-d₃	Isotope-Labeled Compounds Serotonin Transporter Autophagy	Neurological Disease Cancer
Citalopram-d₃ ((±)-Citalopram-d₃) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

HY-11090A

DPC423	Factor Xa Kallikrein Thrombin Ser/Thr Protease	Cardiovascular Disease
DPC423 is a selective and orally active factor Xa inhibitor with a K_is of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits K_is of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 can be used for the study of anticoagulation of arterial thrombosis .

HY-119035

R-75317	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis .

HY-121701

SR33805 analog	Calcium Channel	Cardiovascular Disease
SR 33805 (analog) is an orally active Ca ²⁺ channel blocker that selectively inhibits the proliferation of smooth muscle cells. SR 33805 (analog) reduces calcium uptake by blocking calcium channels, thereby inhibiting smooth muscle cell proliferation induced by serum, platelet-derived growth factor, and basic fibroblast growth factor. SR 33805 (analog) significantly reduces intimal thickening following endothelial injury in rabbits. SR 33805 (analog) shows promise for cardiovascular disease research, such as in early atherosclerosis .

HY-11090

DPC423 free base	Factor Xa Kallikrein Thrombin Ser/Thr Protease	Cardiovascular Disease
DPC423 free base is a selective and orally active factor Xa inhibitor with a K_is of 0.15 (human) and 0.3 (rabbit) nM. DPC423 free base exhibits K_is of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 free base blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 free base can be used for the study of anticoagulation of arterial thrombosis .

HY-116778

Prostaglandin G2	Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Prostaglandin G2 is a prostaglandin peroxide. Prostaglandin G2 acts as a precursor for thromboxane A₂ production, inducing platelet aggregation and serotonin release. Prostaglandin G2 also induces cerebral arteriole injury in anesthetized cats via the generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage. Prostaglandin G2 can be used in studies related to cerebral arteriole injury .

HY-182418

UR-11353	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
UR-11353 is a selective platelet activating factor (PAF) antagonist with long-lasting activity. UR-11353 inhibits PAF-induced platelet aggregation in rabbit platelet-rich plasma. UR-11353 inhibits PAF-induced hypotension in normotensive rats. UR-11353 protects against PAF-induced mortality in mice .

HY-114660

9,11-Methane-epoxy prostaglandin F1α 9,11-Epoxymethano PGH1; 9,11-methane-epoxy PGF1α	Drug Derivative	Cardiovascular Disease
9,11-methane-epoxy Prostaglandin F1α (9,11-Epoxymethano PGH1; 9,11-methane-epoxy PGF1α) is a derivative of prostaglandin H1. 9,11-methane-epoxy Prostaglandin F1α induces aggregation of isolated rabbit platelets (EC₅₀=0.88 µM) and contraction of rabbit aortic strips (EC₅₀=0.11 µM). 9,11-methane-epoxy Prostaglandin F1α induces contraction of isolated guinea pig tracheas (EC₅₀ = 3.4 µM) .

HY-W676872

Dihydroflavokawin B	COX Parasite	Infection Inflammation/Immunology
Dihydroflavokawin B is a selective COX-1 inhibitor with an IC₅₀ of 1.22 μM. Dihydroflavokawin B weakly inhibits COX-2 and 5-LOX. Dihydroflavokawin B inhibits promastigote forms of Leishmania panamensis and Leishmania braziliensis. Dihydroflavokawin B inhibits rabbit platelet aggregation induced by Arachidonic acid, platelet activating factor, and adenosine diphosphate. Dihydroflavokawin B exhibits in vitro anti-inflammatory activity. Dihydroflavokawin B can be used for the research of leishmaniasis .

HY-N17892

Ariskanin A	Others	Cardiovascular Disease
Ariskanin A is a platelet aggregation inhibitor that exists in Aristolochia kankauensis and Aristolochia manshuriensis. Ariskanin A inhibits rabbit platelet aggregation .

HY-182557

KC-11404	Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
KC-11404 is an orally active antihistamine and 5-lipoxygenase inhibitor, with an IC₅₀ of 0.9 μM against guinea pig 5-lipoxygenase. KC-11404 inhibits histamine-induced contraction of isolated guinea pig ileum with an IC₅₀ of 0.26 μM. KC-11404 inhibits PAF-induced rabbit platelet aggregation with an IC₅₀ of 2.0 μM. It inhibits the histamine phase of antigen-induced bronchoconstriction and PAF-induced bronchoconstriction in guinea pigs. KC-11404 can be used for the research of asthma .

HY-101833R

YM-264 (Standard)	Reference Standards Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
YM-264 (Standard) is the analytical standard of YM-264 (HY-101833). This product is intended for research and analytical applications. YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pK_i value of 8.85 for rabbit platelet membranes.

HY-169788

Graveolinine	Others	Cardiovascular Disease
Graveolinine is a quinoline alkaloid, that can be isolated from Ruta chalepensis. Graveolinine exhibits antiplatelet activity, that reduces Arachidonic Acid (HY-109590)- and Collagen-induced aggregation of washed rabbit platelets .

HY-165434

Naxaprostene EL 784	Prostaglandin Receptor	Cardiovascular Disease
Naxaprostene is a prostacyclin analogue. Naxaprostene was much more selective for IP receptors and tended towards partial agonism. Naxaprostene inhibits ADP-induced platelet aggregation. It has been shown to prevent rabbit carotid artery thrombosis.

HY-175986

IP receptor agonist 1	Prostaglandin Receptor	Inflammation/Immunology
IP receptor agonist 1 (compound 6c-14S) is an orally active I prostanoid receptor agonist, with an IC₅₀ of 0.15 μM for inhibiting platelet aggregation induced by ADP (HY-W010918,300 μM) in rabbit platelet-rich plasma. IP receptor agonist 1 can be used for study of Pulmonary arterial hypertension .

HY-W923355

1,2,3-Trieicosapentaenoyl glycerol EPA-TG; Glycerol trieicosapentaenoate; TG(20:5/20:5/20:5)	Others	Others
1,2,3-Trieicosapentaenoyl glycerol (EPA-TG) is a glycerol ester that can be obtained by the reaction of polyunsaturated fatty acids or lower alkyl esters with glycerol catalyzed by alkoxide ions . After two intravenous injections of the EPA-TG emulsion into rabbits, the EPA content in plasma and platelet phospholipids increased markedly . In another study, by administering the EPA-TG emulsion, the production of leukotriene B4 by polymorphonuclear leukocytes in rabbits was reduced by 40% .

Cat. No.	Product Name	Target	Research Area

HY-P3006

Des-Leu10-angiotensin I	Drug Metabolite	Cardiovascular Disease
Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a K_i value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122958

Peucedanocoumarin III	Structural Classification Carpesium cernuum L. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	α-synuclein
Peucedanocoumarin III is an α-synuclein fiber depolymerizer with blood-brain barrier permeability. Peucedanocoumarin III depolymerizes β-sheet aggregate structures, promotes aggregate clearance, inhibits β23-induced cytotoxicity, blocks the formation of Lewy body-like inclusions, and prevents dopaminergic neuron loss. Peucedanocoumarin III can be used in studies related to Parkinson's disease .

HY-111247

Ro 09-0680	Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Plants Source Classification	Others
Ro 09-0680 is a potent inhibitor of rabbit platelet aggregation induced by Collagen with an IC₅₀ of 6.6 μM .

HY-N4267

Yangambin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related
Yangambin is a PAF receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-N8218

Homoeriodictyol 7-O-β-D-glucoside	Cardiovascular Disease Flavonoids Viscum coloratum (Kom.) Nakai Classification of Application Fields Flavonones Phenols Polyphenols Plants Loranthaceae Disease Research Fields Source Classification	Platelet-activating Factor Receptor (PAFR)
Homoeriodictyol 7-O-β-D-glucoside is a natural platelet-activating factor (PAF) antagonist. Homoeriodictyol 7-O-β-D-glucoside inhibits human and rabbit platelet aggregation induced by PAF, with an IC₅₀ of 0.8 μM .

HY-N12995

α-Bulnesene	Entada phaseoloides (L.) Merr. Terpenoids Labiatae Sesquiterpenes Plants Source Classification	Platelet-activating Factor Receptor (PAFR)
α-Bulnesene is a novel PAF receptor antagonist with the IC₅₀ of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation .

HY-N1210

Spiramine A Spiramine C acetate (ester)	Alkaloids Other Alkaloids Terpenoids Rosaceae Spiraea japonica Diterpenoids Plants Source Classification	Bacterial
Spiramine A (Spiramine C acetate (ester)) is a diterpene alkaloid with antitumor and antimicrobial activity. Spiramine A inhibits PAF-induced rabbit platelet aggregation in a concentration-dependent manner, with an IC₅₀ vallue of 6.7 μM .

HY-N11932

Piperulin A	Lignans Piperaceae Phenylpropanoids Plants Piper hongkongense C. de Candolle Source Classification	Platelet-activating Factor Receptor (PAFR)
Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC₅₀ of 7.3 μM .

HY-N12070

11-O-β-D-glucopyranosyl thamnosmonin	Coumarins Phenylpropanoids Cynara scolymus L. Umbelliferae Plants Source Classification	Others
11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP .

HY-116778

Prostaglandin G2	Source Classification	Reactive Oxygen Species (ROS)
Prostaglandin G2 is a prostaglandin peroxide. Prostaglandin G2 acts as a precursor for thromboxane A₂ production, inducing platelet aggregation and serotonin release. Prostaglandin G2 also induces cerebral arteriole injury in anesthetized cats via the generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage. Prostaglandin G2 can be used in studies related to cerebral arteriole injury .

HY-N17892

Ariskanin A	Structural Classification Natural Products Aristolochia zollingeriana Miq. Plants Aristolochiaceae Source Classification	Others
Ariskanin A is a platelet aggregation inhibitor that exists in Aristolochia kankauensis and Aristolochia manshuriensis. Ariskanin A inhibits rabbit platelet aggregation .

HY-169788

Graveolinine	Alkaloids Ruta chalepensis var. latifolia Quinoline Alkaloids Plants Asparagaceae Juss. Source Classification	Others
Graveolinine is a quinoline alkaloid, that can be isolated from Ruta chalepensis. Graveolinine exhibits antiplatelet activity, that reduces Arachidonic Acid (HY-109590)- and Collagen-induced aggregation of washed rabbit platelets .

HY-N3993

Clausine I	Structural Classification Alkaloids Rutaceae Carbazole Alkaloids Plants Clausena excavata N. L. Burman Source Classification	Drug Derivative
Clausine I is a natural alkaloid.

HY-N17941

19-Anhydro-4-epirotungenic acid	Aquifoliaceae Structural Classification Terpenoids Parameria laevigata (Juss.) Moldenke Plants Pentacyclic Triterpenoids Source Classification	Others
19-Anhydro-4-epirotungenic acid is a triterpenoid compound that can be isolated from the bark of Ilex rotunda Thunb. 19-Anhydro-4-epirotungenic acid shows no activity against ADP-induced platelet aggregation .

HY-N19876

WF-5239	Structural Classification Monophenols Microorganisms Phenols Source Classification	Endogenous Metabolite Platelet-activating Factor Receptor (PAFR)
WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis .

Cat. No.	Product Name	Chemical Structure

HY-13511AS

Rupatadine-d4 fumarate
Rupatadine-d₄ fumarate is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with K_i values of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes) .

HY-B1287S

Citalopram-d3 hydrobromide

Citalopram-d₃ ((±)-Citalopram-d₃) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

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rabbit platelets

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