152575-66-1
152575-66-1
Chemical Structure
BMY 45778
- CAS No.: 152575-66-1
- Formula:C26H18N2O5
- Molecular Weight:438.43
IUPAC Name: 2-(3-(4,5-diphenyl-[2,4'-bioxazol]-5'-yl)phenoxy)acetic acid
InChIKey: DSRSEEYZGWTODH-UHFFFAOYSA-N
SMILES: O=C(O)COC1=CC=CC(C2=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)N=CO2)=C1
Biological Activity: BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMY 45778 | 98.98% | BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor. | ||||||||||||||||||||
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BMY 45778 (Standard) | ≥98% | BMY 45778 (Standard) is the analytical standard of BMY 45778 (HY-108565). This product is intended for research and analytical applications. BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.64
HY-120309BMY 42393 -
Similarity Score 0.59
HY-120123FR181157 -
Similarity Score 0.55
HY-W2439892,2'-(1,4-Phenylene)bis(5-phenyloxazole-4-carboxylic acid) -
Similarity Score 0.52
HY-B0808ROxaprozin (Standard) -
Similarity Score 0.51
HY-149848MMP-9-IN-6 -
Similarity Score 0.50
HY-W1599171,4-Di(5-Phenyl-2-oxazolyl)benzene -
Similarity Score 0.50
HY-B0808AOxaprozin potassium -
Similarity Score 0.49
HY-W0287142,3-Diphenylquinoxaline-6-carboxylic acid -
Similarity Score 0.49
HY-162786Nurr1 agonist 11 -
Explore the MedChemAI to find more analogs
References
- [1]. Seiler SM, et al. [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins. 1997 Jan;53(1):21-35. [Content Brief]
