130464-57-2
Chemical Structure
Peucedanocoumarin III
- CAS No.: 130464-57-2
- Formula:C21H22O7
- Molecular Weight:386.40
IUPAC Name: (9S,10R)-9-acetoxy-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-10-yl (E)-2-methylbut-2-enoate
InChIKey: LYUZYPKZQDYMEE-KNXUDURGSA-N
SMILES: C/C=C(C)/C(O[C@@H]1C2=C(OC(C)([C@H]1OC(C)=O)C)C=CC(C=C3)=C2OC3=O)=O
Biological Activity: Peucedanocoumarin III is an α-synuclein fiber depolymerizer with blood-brain barrier permeability. Peucedanocoumarin III depolymerizes β-sheet aggregate structures, promotes aggregate clearance, inhibits β23-induced cytotoxicity, blocks the formation of Lewy body-like inclusions, and prevents dopaminergic neuron loss. Peucedanocoumarin III can be used in studies related to Parkinson's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Peucedanocoumarin III | 95.07% | Peucedanocoumarin III is an α-synuclein fiber depolymerizer with blood-brain barrier permeability. Peucedanocoumarin III depolymerizes β-sheet aggregate structures, promotes aggregate clearance, inhibits β23-induced cytotoxicity, blocks the formation of Lewy body-like inclusions, and prevents dopaminergic neuron loss. Peucedanocoumarin III can be used in studies related to Parkinson's disease. | ||||||||||||||||||||
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- [1]. Ham S, et al. Therapeutic Evaluation of Synthetic Peucedanocoumarin III in an Animal Model of Parkinson's Disease. Int J Mol Sci. 2019;20(21):5481. Published 2019 Nov 4. [Content Brief]
- [2]. Jiang J, et al. Growth Year and Chemotype Synergistically Regulate Coumarin Accumulation and the Associated Transcriptional Profiles in Peucedanum praeruptorum Dunn. Plants (Basel). 2026 Feb 13;15(4):598. [Content Brief]
- [3]. Chen IS, et al. Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum. Phytochemistry. 1996;41(2):525-530. [Content Brief]
Keywords
