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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
rat brain mitochondria
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "rat brain mitochondria" in MCE Product Catalog:
Target:
Cat. No.: HY-137672A
CAS No.: 100929-77-9
Synonyms: 2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate
Research Areas:
2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.
Cat. No.: HY-106808
CAS No.: 118790-71-9
Synonyms: IOS-1.1212
Target:
Research Areas:
Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties .
Cat. No.: HY-103164A
CAS No.: 148589-13-3
Synonyms: CSC
Target:
Research Areas:
8-(3-Chlorostyryl)caffeine (CSC) is an adenosine antagonist with selective activity at the A2a adenosine receptor. 8-(3-Chlorostyryl)caffeine showed 520-fold selectivity in radioligand binding experiments in rat brain. Antagonism of adenylylase by 8-(3-Chlorostyryl)caffeine shows 22-fold selectivity in rat chromaffin cells When 8-(3-Chlorostyryl)caffeine is co-administered with the A1-selective antagonist CPX, It can also further increase exercise activity. 8-(3-Chlorostyryl)caffeine exhibits good MAO-B inhibitory activity in primate mitochondria. 8-(3-Chlorostyryl)caffeine also has excellent A2A receptor affinity .
Cat. No.: HY-184026
CAS No.: 898540-68-6
Target:
Research Areas:
MAO-B-IN-58 (Compound 2e) is a reversible, selective MAO-B inhibitor with an IC50 of 170 nM against rat MAO-B. MAO-B-IN-58 is applicable for the research of Parkinson's disease and Alzheimer's disease .
Cat. No.: HY-W1058437
CAS No.: 131844-46-7
Target:
Research Areas:
(trans)-m-Cl-PCA hydrochloride is a monoamine oxidase inhibitor, with an IC50 of 0.55 μM against rat MAO-A and an IC50 of 0.63 μM against MAO-B. (trans)-m-Cl-PCA hydrochloride inhibits the activities of MAO-A and MAO-B in rat brain mitochondria. (trans)-m-Cl-PCA hydrochloride can be used for the research of neurological disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
