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Cat. No.: HY-184026

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MAO-B-IN-58

MAO-B-IN-58 (Compound 2e) is a reversible, selective MAO-B inhibitor with an IC₅₀ of 170 nM against rat MAO-B. MAO-B-IN-58 is applicable for the research of Parkinson's disease and Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 898540-68-6
Formula: C₁₉H₁₄N₂O₂
Molecular Weight:302.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAO-B-IN-58 Chemical Structure

CAS No.: 898540-68-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

MAO-B

170 nM (IC₅₀)

MAO-A

>1000 nM (IC₅₀)

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

MAO-B-IN-58 potently inhibits MAO-B in rat brain mitochondria with an IC₅₀ of 170 nM and does not inhibit MAO-A^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 898540-68-6
Molecular Weight 302.33
Formula C₁₉H₁₄N₂O₂
SMILES

CC1=CC2=C(C3=CC(OCC4=CC=CC=C4)=CC=C3C2=O)N=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Frédérick R, et al. Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core. J Med Chem. 2006 Jun 15;49(12):3743-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MAO-B-IN-58

All Monoamine Oxidase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MAO-B-IN-58 Related Classifications

HY-184026 Related Classifications