3 Results for "

skin pigmentation disorders

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "skin pigmentation disorders" in MCE Product Catalog:

3',4'-Dihydroxyacetophenone
3',4'-Dihydroxyacetophenone
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Cat. No.: HY-N1775
CAS No.: 1197-09-7
Synonyms: 3,4-DHAP
Category:  

Pinaceae Phenols Polyphenols Plants Picea schrenkiana Fisch. et Mey. Disease Research Fields Cancer

Target:  

Tyrosinase Reactive Oxygen Species (ROS) Keap1-Nrf2 PARP Autophagy Apoptosis

3',4'-Dihydroxyacetophenone (3,4-DHAP) is a phenolic compound with oral bioavailability, possessing potent antioxidant, anti-inflammatory, anticancer and cardiovascular protective activities. 3',4'-Dihydroxyacetophenone inhibits mushroom Tyrosinase activity with an IC50 of 10 μM, thereby suppressing melanogenesis . 3',4'-Dihydroxyacetophenone inhibits platelet aggregation in platelet-rich plasma. 3',4'-Dihydroxyacetophenone reduces ROS levels in human umbilical vein endothelial cells treated with high glucose, upregulates the expression of Nrf2, HO-1 and PARP-1 in cells, and promotes the nuclear translocation of Nrf2 . 3',4'-Dihydroxyacetophenone induces autophagy and apoptosis. 3',4'-Dihydroxyacetophenone inhibits seed germination/growth in most plants. 3',4'-Dihydroxyacetophenone can be used in the research of cancer, neurodegenerative diseases, non-alcoholic steatohepatitis, diabetes, obesity, skin pigmentation disorders, and cardiovascular and cerebrovascular diseases .
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Amorphigenin
Amorphigenin
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Cat. No.: HY-116640
CAS No.: 4208-09-7
Category:  

Flavonoids Leguminosae Amorpha fruticosaL. Plants Other Flavonoids

Target:  

AP-1 Nuclear Factor of activated T Cells (NFAT) AMPK Autophagy

Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders .
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10(E)-Pentadecenoic acid
10(E)-Pentadecenoic acid
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Cat. No.: HY-120996
CAS No.: 321744-58-5
Purity:  99.90%
Synonyms: trans-10-Pentadecenoic acid
Target:  

Tyrosinase Microphthalmia Associated Transcription Factor (MITF)

Research Areas:  

Metabolic Disease

10 (E)-Pentadecenoic acid (trans-10-Pentadecenoic acid) is a melanin synthesis inhibitor. 10 (E)-Pentadecenoic acid inhibits nuclear translocation and reduces the protein level of phosphorylated microphthalmia-associated transcription factor (MITF), as well as decreases intracellular tyrosinase activity. 10 (E)-Pentadecenoic acid can be used in the research of skin pigmentation disorders .
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