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Results for "

thromboplastin time

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Drug Metabolite (1) Factor Xa (4) Factor XI (1) HIV (1) Thrombin (4)
By Research Areas:	Cardiovascular Disease (11) Infection (1)
Oligonucleotides:	Antisense Oligonucleotides (1)

Inhibitors & Agonists

Inhibitory Antibodies

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70541B

Canine Factor IX	Biochemical Assay Reagents	Cardiovascular Disease
Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B .

HY-P99794

Osocimab BAY 1213790	Factor Xa	Cardiovascular Disease
Osocimab (BAY 1213790), an anti-FXIa antibody (K_i=2.4 nM; EC₅₀=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects .

HY-149906

Trecovirsen GEM91	HIV	Infection
Trecovirsen is an antiviral agent targeting HIV gag mRNA, which hybridizes with complementary HIV gag mRNA at the initiation site. Trecovirsen induces a reversible, dose-dependent prolongation of activated partial thromboplastin time via its polyanionic properties. Trecovirsen is applicable to research related to HIV infection .

HY-122813

Dabigatran acyl-β-D-glucuronide	Drug Metabolite Thrombin	Cardiovascular Disease
Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran (HY-10163). Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.

HY-168712

FXIa-IN-15	Factor Xa	Cardiovascular Disease
FXIa-IN-15 (Compound (S)-10h) is an inhibitor for Factor XIa (FXIa) and plasma kallikrein (PKa) with an IC₅₀ of 0.38 nM and 59.2 nM. FXIa-IN-15 exhibits anticoagulant efficacy, that extends 50% activated partial thromboplastin time (aPTT) with EC_1.5X of 0.55 μM .

HY-106404

RPR 130737	Factor Xa	Cardiovascular Disease
RPR 130737 is a selective, potent and competitive inhibitor for factor Xa with a K_i of 2.4 nM. RPR 130737 shows selectivity of more than 1000-fold over thrombin, activated protein C, plasmin, tissue-plasminogen activator and trypsin. RPR 130737 can prolong plasma activated partial thromboplastin time and prothrombin time. RPR 130737 shows no effect on platelet aggregation. RPR 130737 can be used for the research of cardiovascular disease, such as thrombosis .

HY-170485

Thrombin inhibitor 13	Thrombin	Cardiovascular Disease
Thrombin inhibitor 13 (Compound 13a) is a covalent and reversible inhibitor for thrombin (FIIa) with an IC₅₀ of 0.7 nM. Thrombin inhibitor 13 prolongs the activated partial thromboplastin time (aPTT) and prothrombin time (PT), exhibits antithrombotic and anticoagulant activities .

HY-19222

CVS-1123	Thrombin	Cardiovascular Disease
CVS-1123 is an orally active direct thrombin inhibitor. CVS-1123 inhibits in vitro platelet aggregation of γ-thrombin and prolongs activated partial thromboplastin time. CVS-1123 alters the thrombotic response to deep vessel wall damage in arterial and venous circulation. CVS-1123 can be used in antithrombotic studies

HY-N7576

Anemarrhenasaponin Ia	Others	Cardiovascular Disease
Anemarrhenasaponin Ia is a steroidal saponin that can be isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Anemarrhenasaponin Ia inhibits platelet aggregation. Anemarrhenasaponin Ia induces mild concentration-dependent hemolysis. Anemarrhenasaponin Ia inhibits fMLP- and AA-induced superoxide anion production, while enhancing PMA-induced superoxide anion production. Anemarrhenasaponin Ia can be used in studies related to thrombosis .

HY-165360

JJ1	Thrombin	Cardiovascular Disease
JJ1 is a selective α-thrombin inhibitor with a K_i of 0.019 μM. JJ1 directly binds to the active site of α-thrombin to block its catalytic activity. JJ1 exhibits antithrombotic effects and prolongs activated partial thromboplastin time, prothrombin time, and tail bleeding time in mice. JJ1 can be used for the research of thrombotic diseases .

HY-182420

DJT06001	Factor Xa	Cardiovascular Disease
DJT06001 is an orally active, highly selective Factor Xa inhibitor. DJT06001 shows inhibition with K_i of 0.99 nM, IC₅₀ of 2.53 nM in prothrombinase complex and 3.33 nM in human plasma. DJT06001 dose-dependently prolongs PT and APTT, inhibits thrombus formation in vivo. DJT06001 can be used for the research of thromboembolic diseases .

HY-117290A

BMS-962212 hydrochloride	Factor XI	Cardiovascular Disease
BMS-962212 hydrochloride is a selective coagulation factor XIa inhibitor and acute antithrombotic agent. BMS-962212 hydrochloride can be used in the research of thrombosis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99794

Osocimab BAY 1213790	Factor Xa	Cardiovascular Disease
Osocimab (BAY 1213790), an anti-FXIa antibody (K_i=2.4 nM; EC₅₀=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects .

Anemarrhenasaponin Ia	Structural Classification Liliaceae Classification of Application Fields Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Others
Anemarrhenasaponin Ia is a steroidal saponin that can be isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Anemarrhenasaponin Ia inhibits platelet aggregation. Anemarrhenasaponin Ia induces mild concentration-dependent hemolysis. Anemarrhenasaponin Ia inhibits fMLP- and AA-induced superoxide anion production, while enhancing PMA-induced superoxide anion production. Anemarrhenasaponin Ia can be used in studies related to thrombosis .

Cat. No.	Product Name		Classification

HY-149906

Trecovirsen GEM91		Antisense Oligonucleotides
Trecovirsen is an antiviral agent targeting HIV gag mRNA, which hybridizes with complementary HIV gag mRNA at the initiation site. Trecovirsen induces a reversible, dose-dependent prolongation of activated partial thromboplastin time via its polyanionic properties. Trecovirsen is applicable to research related to HIV infection .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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