151275-19-3
Chemical Structure
CVS-1123
- CAS No.: 151275-19-3
- Formula:C24H42N6O6
- Molecular Weight:510.63
IUPAC Name: methyl (S)-4-((S)-2-(((S)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-4-oxo-3-(2-propylpentanamido)butanoate
InChIKey: ICMSWQUELAGTTR-FHWLQOOXSA-N
SMILES: O=C([C@H](CC(OC)=O)NC(C(CCC)CCC)=O)N1[C@H](C(N[C@H](C=O)CCCNC(N)=N)=O)CCC1
Biological Activity: CVS-1123 is an orally active direct thrombin inhibitor. CVS-1123 inhibits in vitro platelet aggregation of γ-thrombin and prolongs activated partial thromboplastin time. CVS-1123 alters the thrombotic response to deep vessel wall damage in arterial and venous circulation. CVS-1123 can be used in antithrombotic studies[1][2]
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CVS-1123 | CVS-1123 is an orally active direct thrombin inhibitor. CVS-1123 inhibits in vitro platelet aggregation of γ-thrombin and prolongs activated partial thromboplastin time. CVS-1123 alters the thrombotic response to deep vessel wall damage in arterial and venous circulation. CVS-1123 can be used in antithrombotic studies | |||||||||||||||||||||
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References
- [1]. Rebello SS, et al. CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury. J Cardiovasc Pharmacol. 1997 Feb;29(2):240-9. [Content Brief]
- [2]. Cousins GR, et al. Orally effective CVS-1123 prevents coronary artery thrombosis in the conscious dog. Circulation. 1996 Oct 1;94(7):1705-12. [Content Brief]
