3053222-76-4
3053222-76-4
Chemical Structure
FXIa-IN-15
- CAS No.: 3053222-76-4
- Formula:C32H23ClF3N7O4
- Molecular Weight:662.02
InChIKey: BHLRKIWHCPZELB-MHZLTWQESA-N
SMILES: COC1=CN(C(C=C1C2=CC(Cl)=CC=C2N3C=C(N=N3)C(F)(F)F)=O)[C@H](C4=CN(N=N4)C5=CC=C(C=C5)C(O)=O)CC6=CC=CC=C6
Biological Activity: FXIa-IN-15 (Compound (S)-10h) is an inhibitor for Factor XIa (FXIa) and plasma kallikrein (PKa) with an IC50 of 0.38 nM and 59.2 nM. FXIa-IN-15 exhibits anticoagulant efficacy, that extends 50% activated partial thromboplastin time (aPTT) with EC1.5X of 0.55 μM[1].
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FXIa-IN-15 | FXIa-IN-15 (Compound (S)-10h) is an inhibitor for Factor XIa (FXIa) and plasma kallikrein (PKa) with an IC50 of 0.38 nM and 59.2 nM. FXIa-IN-15 exhibits anticoagulant efficacy, that extends 50% activated partial thromboplastin time (aPTT) with EC1.5X of 0.55 μM. | |||||||||||||||||||||
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References
Keywords
