1941243-22-6
Chemical Structure
ONO-7684
Synonym(s): ONO-5450598
- CAS No.: 1941243-22-6
- Formula:C23H16ClF2N9O
- Molecular Weight:507.88
InChIKey: YVACZLFZCFGMPP-QGZVFWFLSA-N
SMILES: O=C1N2[C@@H](C3=C(F)N=C(C4=C(N=C(C=C4)N)F)N3)CCC2=CC(C5=C(N6C=NN=N6)C=CC(Cl)=C5)=C1
Biological Activity: ONO-7684 (ONO-5450598) is an orally active coagulation factor XIa (FXIa) inhibitor with a Ki value of 2 nM against human FXIa. ONO-7684 inhibits human FXIa in a competitive and reversible manner, reduces factor XI coagulation activity, prolongs activated partial thromboplastin time in a dose-dependent manner, and exerts no significant effects on PT/INR and the activity of related serine proteases. ONO-7684 exerts antithrombotic effects in vivo without prolonging bleeding time. ONO-7684 can be used in studies related to thromboembolic diseases[1][2].
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ONO-7684 | ONO-7684 (ONO-5450598) is an orally active coagulation factor XIa (FXIa) inhibitor with a Ki value of 2 nM against human FXIa. ONO-7684 inhibits human FXIa in a competitive and reversible manner, reduces factor XI coagulation activity, prolongs activated partial thromboplastin time in a dose-dependent manner, and exerts no significant effects on PT/INR and the activity of related serine proteases. ONO-7684 exerts antithrombotic effects in vivo without prolonging bleeding time. ONO-7684 can be used in studies related to thromboembolic diseases. | |||||||||||||||||||||
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- [1]. Beale D, et al. ONO-7684 a novel oral FXIa inhibitor: Safety, tolerability, pharmacokinetics and pharmacodynamics in a first-in-human study. British journal of clinical pharmacology. 2021 Aug;87(8):3177-3189.
- [2]. Kouyama S, et al. Discovery of ONO-5450598, a highly orally bioavailable small molecule factor XIa inhibitor: the pharmacokinetic and pharmacological profiles[J]. Res. Pract. Thromb. Haemost, 2017, 1(1): 1038.
Keywords
