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Results for "

tuberculosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Akt (8) Amino Acid Derivatives (1) Aminopeptidase (1) AMPK (1) Androgen Receptor (2) Antibiotic (105) Antifolate (1) AP-1 (1) Apoptosis (21) Arginase (2) Aryl Hydrocarbon Receptor (1) ATP Synthase (3) ATP-binding cassette (ABC) transporters (1) Autophagy (10) Bacterial (550) Bcl-2 Family (4) Biochemical Assay Reagents (14) Calcium Channel (5) Carbonic Anhydrase (4) Caspase (7) Cholinesterase (ChE) (1) ClpP (1) COX (8) Cytochrome P450 (5) Dengue Virus (2) Dihydrofolate reductase (DHFR) (2) DNA Methyltransferase (1) DNA/RNA Synthesis (24) Drug Derivative (6) Drug Intermediate (17) Drug Metabolite (9) EGFR (1) Endogenous Metabolite (20) Environmental Pollutants (1) Epigenetic Reader Domain (2) ERK (1) Estrogen Receptor/ERR (1) Fatty Acid Synthase (FASN) (1) Fluorescent Dye (8) Fungal (20) GABA Receptor (2) Heme Oxygenase (HO) (1) Histamine Receptor (1) Histone Acetyltransferase (1) HIV (5) HSP (1) HSV (2) IAP (2) IFNAR (1) iGluR (2) IMPDH (1) Influenza Virus (1) Insecticide (1) Interleukin Related (14) Isotope-Labeled Compounds (18) JAK (2) JNK (2) Keap1-Nrf2 (3) LXR (1) MAPKAPK2 (MK2) (2) MDM-2/p53 (2) MHC (1) Mitochondrial Metabolism (2) MMP (4) Monoamine Oxidase (2) mTOR (1) NF-κB (9) NO Synthase (4) Orthopoxvirus (2) P-glycoprotein (4) p38 MAPK (6) Parasite (20) PARP (1) Phosphatase (4) Phosphodiesterase (PDE) (2) Potassium Channel (2) PPAR (3) PROTACs (3) Proteasome (1) Proton Pump (3) Reactive Oxygen Species (ROS) (9) Reference Standards (57) Reverse Transcriptase (1) RIG-I-like receptor (RLR) (1) ROR (1) SARS-CoV (1) Ser/Thr Kinase (2) Sodium Channel (1) STAT (1) Succinate Dehydrogenase (1) TGF-beta/Smad (5) TGF-β Receptor (1) Thymidylate Synthase (8) TNF Receptor (10) Toll-like Receptor (TLR) (8) Topoisomerase (7) Tyrosinase (1) VEGFR (3) Virus Protease (1)
By Research Areas:	Cancer (70) Cardiovascular Disease (14) Endocrinology (2) Infection (596) Inflammation/Immunology (84) Metabolic Disease (27) Neurological Disease (20)
Oligonucleotides:	Nucleotide Analogs (1) Adjuvant (3) Cholesterol (1)

650

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

111

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-177105

JNJ-6640	Bacterial	Infection
JNJ-6640 is an inhibitor targeting mycobacterial PurF (the first enzyme in the de novo purine biosynthesis pathway) with potent anti-tuberculosis activity. JNJ-6640 exhibits bactericidal activity against Mycobacterium tuberculosis in vitro, with an MIC₉₀ of 8.6 nM. JNJ-6640 disrupts de novo purine biosynthesis, inhibits M. tuberculosis DNA replication in vivo. JNJ-6640 exhibits anti-tuberculosis efficacy in acutely infected mice. JNJ-6640 can be used for the study of tuberculosis .

HY-13579

BTZ043 4 Publications Verification	Bacterial Antibiotic	Infection
BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis* H37Rv* and Mycobacterium smegmatis, respectively.

HY-100725

BM212 4 Publications Verification	Bacterial	Infection
BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .

HY-B0306

Prothionamide Protionamide	Bacterial	Infection
Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a K_m value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy .

HY-135174

L-Cysteine-glutathione disulfide	Endogenous Metabolite	Infection
L-Cysteine-glutathione disulfide is a metabolite in plasma that can be used in biomarker studies for tuberculosis cure .

HY-128866A

(Rac)-TBAJ-876	Bacterial	Infection
(Rac)-TBAJ-876 is a racemate of TBAJ-876. TBAJ-876 is the inhibitor of mycobacterium tuberculosis. TBAJ-876 is the analogue of the anti-tuberculosis agent Bedaquiline (HY-14881). TBAJ-876 has the potential for the research of tuberculosis .

HY-14990

Sudoterb LL 3858	Bacterial	Infection
Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent .

HY-P3270

Capreomycin	Bacterial Antibiotic	Infection
Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation

HY-171615

(4-Phenylphenoxy)phosphonic acid	Phosphatase	Infection
(4-Phenylphenoxy) phosphonic acid is a protein tyrosine phosphatase (PTP) inhibitor (K_M: 86 μM). (4-Phenylphenoxy) phosphonic acid can be used in tuberculosis research .

HY-134648

Ganfeborole GSK656 free base; GSK3036656 free base; GSK070 free base	Bacterial	Infection
Ganfeborole (GSK656 free base) is a potent, selective and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase, with an IC₅₀ of 0.20 μM. Ganfeborole can be used for the research of tuberculosis .

HY-W002071

2-Quinoxalinecarboxylic acid	Bacterial	Infection
2-Quinoxalinecarboxylic acid is an antibacterial agent targeting Mycobacterium tuberculosis (MIC: >128 µg/mL). 2-Quinoxalinecarboxylic acid is promising for research of tuberculosis .

HY-W716673

Ftivazide Phthivazide	Bacterial	Infection
Ftivazide has anti-tuberculosis activity .

HY-124781

ML406	Bacterial Antibiotic	Infection
ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC₅₀ of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis .

HY-P2848A

Cholesterol oxidase, rhodococcus sp	Toll-like Receptor (TLR)	Infection Metabolic Disease
Cholesterol oxidase, Rhodococcus sp. is a key enzyme in the cholesterol degradation process. It catalyzes the isomerization and oxidation of cholesterol mediated by the coenzyme FAD. Research indicates that cholesterol oxidase plays a crucial role in the pathogenicity of Mycobacterium tuberculosis by modulating the host macrophage immune response through inhibition of the Toll-like receptor 2 (TLR2) signaling pathway, thereby enhancing the survival of Mycobacterium tuberculosis. Cholesterol oxidase, from Rhodococcus sp., shows potential for research in the field of tuberculosis .

HY-W064918

NITD-304	Bacterial	Infection
NITD-304 is an orally active anti-tuberculosis agent. NITD-304 exerts inhibitory and bactericidal activities gainst Mycobacterium tuberculosis and multidrug-resistant Mycobacterium tuberculosis. NITD-304 inhibits mycobacterial cell wall biosynthesis and demonstrates synergistic or additive growth inhibitory activity with select antibacterial agents. NITD-304 shows low risk of cardiotoxicity and drug-drug interactions, with no inhibition of major cytochrome P-450 enzymes or hERG channel. NITD-304 can be used for the research of tuberculosis and multidrug-resistant tuberculosis .

HY-116611

IMB-YH-8	Ser/Thr Kinase Bacterial	Infection
IMB-YH-8 is a serine/threonine protein kinase (PknB) inhibitor. IMB-YH-8 has strong antibacterial activity against Mycobacterium tuberculosis (MIC = 0.25 µg/mL). IMB-YH-8 can be used in the research of tuberculosis .

HY-157431

*Mycobacterium Tuberculosis-IN-2*	Bacterial	Infection
Mycobacterium Tuberculosis-IN-2 (Compound 29) is a bacterial inhibitor that effectively inhibits Mycobacterium Tuberculosis. Mycobacterium Tuberculosis-IN-2 can be used in tuberculosis research (MIC = 0.07-0.16 μM) .

HY-114147

Tuberculosis inhibitor 3	Bacterial	Infection Inflammation/Immunology
Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against agent-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability .

HY-179301

GuaB-IN-2	Bacterial	Infection
GuaB-IN-2 (Compound 54) is a GuaB inhibitor, with an IC₅₀ of 0.2 nM for M. tuberculosis GuaB. GuaB-IN-2 can be used in the research of bacterial infections and tuberculosis .

HY-151514

Antituberculosis agent-5	Bacterial	Infection
Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosis UDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC₅₀ value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL .

HY-172349

JNJ-2901	Bacterial	Infection
JNJ-2901 is an inhibitor of *M. tuberculosis* cytochrome bc1:aa3*. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis* H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research .

HY-B2077

Enviomycin Tuberactinomycin N	Bacterial Antibiotic	Infection
Enviomycin (Tuberactinomycin N) is a antibacterial antibiotic. Enviomycin has been used to research chronic cavitary pulmonary tuberculosis .

HY-163181

MSU-43085	Bacterial	Infection
MSU-43085 is an orally active MmpL3 inhibitor of Mycobacterium tuberculosis (Mtb). MSU-43085 effectively inhibits Mtb in an acute murine tuberculosis infection model. MSU-43085 can be used in tuberculosis research .

HY-124814

C215	Bacterial	Infection
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC₉₀ of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages .

HY-172456

JSF-4898	Bacterial	Infection
JSF-4898 is an orally active inhibitor of the MenG enzyme in Mycobacterium tuberculosis. JSF-4898 has MIC of 0.78 μM against Mycobacterium tuberculosis H37Rv. JSF-4898 can enhance the efficacy of Rifampicin (HY-B0272) in a subacute model of Mycobacterium tuberculosis infection in mice .

HY-111402

Pyridomycin Erizomycin; NSC 246134	Bacterial Antibiotic	Infection
Pyridomycin (Erizomycin) is a selective and low cytotoxic inhibitor of Mycobacterium tuberculosis that effectively targets InhA. Pyrdomycin is also an antibiotic that can be obtained from metabolites of Dactylosporangium fulvum. Pyrdomycin can be used in the study of bacterial infections such as tuberculosis .

HY-115884

PptT-IN-3	Bacterial	Infection Inflammation/Immunology
PptT-IN-3 (compound 5p) is a potent inhibitor of with phosphopantetheinyl phosphoryl transferase (PptT) an IC₅₀ of 3.5 μM. Phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. PptT-IN-3 has the potential for the research of tuberculosis .

HY-40156A

*Mycobacterium Tuberculosis-IN-5*	Bacterial	Infection
Mycobacterium Tuberculosis-IN-5 (Compound 11) is the HCl salt form of 5-Fluoroindole (HY-40156). Mycobacterium Tuberculosis-IN-5 is an antibacterial agent, that inhibits Mycobacterium tuberculosis with a MIC of 29.1 μM. Mycobacterium Tuberculosis-IN-5 exhibits metabolic stability in rat liver microsomes. Mycobacterium Tuberculosis-IN-5 exhibits anti-tuberculosis efficacy in mice .

HY-146348

Tuberculosis inhibitor 5	Bacterial	Infection
Tuberculosis inhibitor 5 (Compound 11i) is a potent antimycobacterial biphenyl analogue without noticeable cytotoxicity. Tuberculosis inhibitor 5 is an anti-tuberculosis agent .

HY-172397

*Mycobacterium Tuberculosis-IN-7*	Bacterial	Infection
Mycobacterium Tuberculosis-IN-7 (Compound 4c) inhibits M. tuberculosis H37Ra with MIC of 5.34 μg/mL. Mycobacterium Tuberculosis-IN-7 exhibits slight cytotoxicity in cancer cell Vero, A549, and HepG2 (IC₅₀s >50 μM) .

HY-NP022

Mycobacterium bovis bacterial protein Bacillus tuberculosis bovis	Biochemical Assay Reagents Bacterial	Infection
Mycobacterium bovis bacterial protein is a member of the Mycobacterium tuberculosis complex. Mycobacterium bovis bacterial protein causes tuberculosis in bovines .

HY-115900

Tuberculosis inhibitor 4	Bacterial	Infection
Tuberculosis inhibitor 4 (compound 16), a mandelic acid-based spirothiazolidinone, has potent antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv with the high inhibition value 98% at lower than 6.25 µg/mL concentration .

HY-155648

Tuberculosis inhibitor 6	Bacterial	Infection
Tuberculosis inhibitor 6 (compound 2c) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC₉₀ of ≤1.66 μM) and Mycobacterium marinum (MIC₉₀ of 2.65 μM) .

HY-155649

Tuberculosis inhibitor 7	Bacterial	Infection
Tuberculosis inhibitor 7 (compound 2d) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC₉₀ of 0.63 μM) and Mycobacterium marinum (MIC₉₀ of 0.63 μM) .

HY-155651

Tuberculosis inhibitor 9	Bacterial	Infection
Tuberculosis inhibitor 9 (compound 3d) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC₉₀ of 0.64 μM) and Mycobacterium marinum (MIC₉₀ of 0.64 μM) .

HY-155650

Tuberculosis inhibitor 8	Bacterial	Infection
Tuberculosis inhibitor 8 (compound 3b) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC₉₀ of 0.69 μM) and Mycobacterium marinum (MIC₉₀ of 0.69 μM) .

HY-169635

*Mycobacterium Tuberculosis-IN-6*	Bacterial	Infection
Mycobacterium Tuberculosis-IN-6 (compound b1) is an inhibitor of Mycobacterium tuberculosis enoyl reductase InhA, with IC₅₀ of 7.74 μM. Mycobacterium Tuberculosis-IN-6 can be used for antibacterial research .

HY-173375

*Mycobacterium Tuberculosis-IN-8*	Bacterial	Infection
Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB) with an MIC value of 6.25 µg/mL against MTB H37Rv. Mycobacterium Tuberculosis-IN-8 shows potent antitubercular activities, inhibiting mycolic acid biosynthesis critical for bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 is promising for research of antitubercular agents .

HY-49071

Tuberculosis inhibitor 12	Bacterial	Infection
Tuberculosis inhibitor 12 (compound 12) is an oxadiazole derivative and an inhibitor of Mycobacterium tuberculosis. The inhibition rates of Tuberculosis inhibitor 12 (20 μM) on 7H9-Tw-OADC and 7H9-Tw-OADC reached 82% and 78% respectively .

HY-156359

Tuberculosis inhibitor 10	Bacterial	Others
Tuberculosis inhibitor 10 shows moderate inhibitory effect on the enzymatic activity of MSMEG_6649. Tuberculosis inhibitor 10 enhances the inhibitory activity of PAS against mycobacteria .

HY-156361

Tuberculosis inhibitor 11	Bacterial	Infection
Tuberculosis inhibitor 11 (Compound 14) can sensitize the antimycobacterial activity of the antitubercular agent .

HY-119938

Tuberculosis inhibitor 1	Bacterial	Infection
Tuberculosis inhibitor 1 is a potent and non-cytotoxic *trypanosoma brucei* growth inhibitor with an EC₅₀ of 5 nM .

HY-147661

DHFR-IN-2	Antifolate	Infection
DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC₅₀ of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research .

HY-160653

JPL	Bacterial	Infection
JPL is a InhA-cofactor-ligand 3FNG inhibitor, and can be used for study of tuberculosis .

HY-150967

MmpL3-IN-1	Bacterial	Infection
MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis .

HY-151550

Mtb-cyt-bd oxidase-IN-3	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-3 (compound 1u) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.36 μM. Mtb-cyt-bd oxidase-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC=32 μM). Mtb-cyt-bd oxidase-IN-3 can be used in tuberculosis research .

HY-171151

CPZEN-45	Bacterial	Infection
CPZEN-45 is a bacterial translocase I inhibitor with potent anti-tuberculosis activity. CPZEN-45 is promising for research of tuberculosis .

HY-147047

InhA-IN-2	Bacterial	Infection
InhA-IN-2 (Compound 23) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 0.31 μM .

HY-160644

8PC	Bacterial	Infection
8PC is a the ligand of InhA-NADH-JPM, and can be used for study of tuberculosis .

HY-162508

KSK-104	Bacterial	Infection
KSK-104 has potent antibacterial activity against Mycobacterium tuberculosis (MIC=0.78 μM). The role of KSK-104 is mainly involved in the synthesis and recovery pathways of pyridoxal 5'-phosphate (PLP), PLP-dependent enzymes and oxidative stress networks. KSK-104, as a candidate molecule for novel anti-tuberculosis drugs, can be used to develop research against drug-resistant mycobacterium tuberculosis .

Cat. No.	Product Name

HY-L142

Anti-tuberculosis Compound Library

148 compounds

Tuberculosis (TB), usually caused by bacteria (Mycobacterium tuberculosis), is an infectious disease that mainly affects the lungs. According to the statistics of the World Health Organization (WHO), 10 million people suffer from tuberculosis every year, and 1.5 million people die of tuberculosis every year, which makes tuberculosis the number one killer of infectious diseases.

Tuberculosis can be cured through the standard 6-month course of treatment of four kinds of antibiotics. Common drugs include rifampicin and isoniazid. In some cases, TB bacteria do not respond to standard drugs, that is, patients with drug-resistant tuberculosis. The treatment of drug-resistant tuberculosis takes longer and is more complex. In the face of the resurgence of tuberculosis in the world and the rapid emergence of multi drug resistant tuberculosis, it is very important to develop new anti-tuberculosis drugs or new clinical treatment schemes for existing anti mycobacterium drugs.

MCE supplies a unique collection of 148 compounds with clear anti-tuberculosis activity. MCE Anti-tuberculosis Compound Library is a useful tool for anti-tuberculosis related research and anti-tuberculosis drug development

HY-L924

Boronic acid/boronic ester fragment library

1,488 compounds

Boronic acid and boronic ester represent a relatively novel and promising chemical structure in drug design. Boronic acid exists in an sp²-hybridized state, possessing an empty p-orbital that can act as a Lewis acid to accept lone pairs from heteroatoms (O, N, or S). This Lewis acidity enables it to form reversible covalent bonds with amino acid residues such as lysine, serine, threonine, and histidine. Currently, five FDA-approved drugs containing boronic acid or boronic ester predominantly involve such covalent binding mechanisms in their interactions with target proteins. Furthermore, boronic acid can serve as a bioisostere for carboxylic acids, phosphates, and phenolic groups, utilized to improve pharmacokinetic properties and enhance drug efficacy.

To date, five boron-containing drugs have been approved by the FDA. The unique properties of boronic acids and boronic esters confer significant potential in drug design, with applications spanning cancer therapy (e.g., multiple myeloma), anti-infectives (e.g., fungal infections, tuberculosis), anti-inflammatory treatments (e.g., atopic dermatitis), antibacterial agents (e.g., carbapenem-resistant bacterial infections), and Reactive Oxygen Species (ROS)-responsive prodrugs, among others. The MCE Boronic Acid/Boronic Ester Fragment Library, which contains 1,488 compounds, serves as a valuable tool for the development of boron-containing drugs.

Cat. No.	Product Name	Type

HY-B1046

Clofazimine

10+ Cited Publications

Fluorescent Dye

Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .

HY-B1539A

Fuchsine base monohydrochloride Magenta base monohydrochloride; Basic Fuchsin monohydrochloride; Rosaniline Base monohydrochloride	Fluorescent Dye
Fuchsine base (Magenta base; Basic Fuchsin) monohydrochloride is a triaminotriphenylmethane dye. Fuchsine base monohydrochloride has anesthetic, bactericidal and fungicidal properties. Fuchsine base monohydrochloride can be used for the staining of collagen, muscle, mitochondria and tuberculosis. Fuchsine base monohydrochloride is commonly used as a counterstain in Gram staining .

HY-D2919

DMN-Tre

Fluorescent Dye

DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling . DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis .

HY-W250306

Carbol fuchsin

Fluorescent Dye

Carbol fuchsin is a histological stain used in microbiology to distinguish acid-fast bacteria from non-acid-fast bacteria. It is a mixture of basic fuchsin, phenol, and water and is commonly used in the Ziehl-Neelsen staining technique for the detection of tuberculosis and other mycobacterial infections. Carbol fuchsin stains the cell walls of acid-fast bacteria bright red, while other cells are unstained or slightly stained. This makes it easier to see and identify these microbes under a microscope. Carbol fuchsin is also used in veterinary medicine and phytopathology for similar purposes.

HY-B1046R

Clofazimine (Standard)

Fluorescent Dye

Clofazimine (Standard) is the analytical standard of Clofazimine. This product is intended for research and analytical applications. Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .

HY-20457G

TL8-506	Fluorescent Dye
TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC₅₀ of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy .

HY-D2983

ARHB	Fluorescent Dye
ARHB is a highly selective and sensitive NAT2 fluorescent probe suitable for real-time detection of NAT2 activity in various bacteria. ARHB can successfully penetrate the bacterial cells, and the fluorescence intensity is positively correlated with the expression level of NAT2. ARHB is used for high-throughput screening of natural inhibitors for tuberculosis .

HY-D2730

N14G-Fe	Fluorescent Dye
N14G-Fe, the Fe ³⁺-chelated form of N14G, identifies Mtb in sputum samples with tuberculosis, exhibiting exceptional fluorescence. N14G-Fe can effectively traverse the cell wall and inner membrane region where IrtAB is located .

HY-D2729

Cy3-NO2-Tre

Fluorescent Dye

Cy3-NO2-Tre is a nitroreductase-responsive cyanine-based fluorescent probe that specifically labels Mycobacterium tuberculosis (Mtb). Cy3-NO2-tre generated fluorescence after activation by a specific nitroreductase, Rv3368c, which is conserved in the Mycobacteriaceae. Cy3-NO2-tre effectively imaged mycobacteria within infected host cells, tracked the infection process, and visualized Mycobacterium smegmatis being endocytosed by macrophages (Ex/Em= 540-550/575-625 nm) .

HY-D2733

N14G	Fluorescent Dye
N14G is a fluorescent dye that can be used to stain bacteria such as Mycobacterium tuberculosis .

HY-D3391

RMR-Tre

Fluorescent Dye

RMR-Tre is a fluorescent probe targeting the mycobacterial acyltransferase Ag85. Under the catalysis of Ag85, RMR-Tre undergoes 6-position mycoloylation and anchors to the mycobacterial membrane, while achieving fluorescence activation by inhibiting the intramolecular twisted charge transfer state transition. RMR-Tre can distinguish live mycobacteria from dead ones through metabolism-driven labeling, enabling rapid, wash-free, low-background detection of viable bacteria. RMR-Tre reports the drug resistance of Mycobacterium tuberculosis via the trehalose catalytic shift activity readout associated with TreS. In addition, RMR-Tre can be combined with flow cytometry or high-content imaging techniques to visualize and quantitatively analyze the metabolic heterogeneity of Mycobacterium tuberculosis related to persistence and drug resistance. RMR-Tre is widely used in tuberculosis-related research .

HY-D2991

CDG-DNB3	Fluorescent Dye
CDG-DNB3 is a selective fluorescent probe for Mycobacterium tuberculosis. CDG-DNB3 provides rapid and specific labeling of live Mycobacterium tuberculosis. CDG-DNB3 can image Bacillus Calmette-Guérin phagocytosis in real time .

HY-D1737

RADA

Fluorescent Dye

RADA is a fluorescent D-amino acid (FDAA) with high photostability and thermostability, which emits yellow-to-orange fluorescence. RADA shows low outer membrane permeability in wild-type Gram-negative Escherichia coli, but it targets penicillin-binding proteins and L,D-transpeptidases, mimics the interaction between acyl acceptors and enzyme intermediates, and integrates into peptidoglycan during biosynthesis. As a peptidoglycan labeling reagent, RADA metabolically integrates into the nascent peptidoglycan of live bacterial cells, labels the peptidoglycan at the poles and lateral walls of mycobacteria, and enables visualization of peptidoglycan synthesis and remodeling processes. RADA serves as a non-specific stain for fixed cells, is non-toxic to bacterial cells, and its red-shifted excitation/emission spectra reduce phototoxicity. RADA also supports virtual pulse-chase labeling experiments and stochastic optical reconstruction microscopy for sub-diffraction-limited imaging of bacterial cell walls .

HY-D3389

sCy5DL-amide

Fluorescent Dye

sCy5DL-amide is an amidated fluorescent D-amino acid conjugated to Sulfo-Cyanine 5, and a peptidoglycan labeling agent. sCy5DL-amide incorporates into bacterial peptidoglycan cell wall via transpeptidase-mediated reactions, replacing the fourth or fifth D-amino acid of the peptidoglycan stem peptide for visualization of nascent peptidoglycan biosynthesis. sCy5DL-amide produces clear cell outline, septum labeling, and high localization density in Bacillus subtilis, including a 'V-shape' pattern at cell-cell contact areas. sCy5DL-amide exhibits robust incorporation into Gram-positive bacteria and mycobacteria, with reduced incorporation into Gram-negative bacteria (Ex/Em = 646/666 nm) .

Cat. No.	Product Name	Type

HY-40146

tert-Butyl 3-oxoazetidine-1-carboxylate N-Boc-3-azetidinone	Biochemical Assay Reagents
tert-Butyl 3-oxoazetidine-1-carboxylate is a synthetic intermediate. tert-Butyl 3-oxoazetidine-1-carboxylate is used in the discovery and development of compounds targeting cancer and tuberculosis .

HY-Y0607

4-Nitrobenzoic acid	Biochemical Assay Reagents
4-Nitrobenzoic acid is a nitroaromatic compound that can be used in the synthesis of other active compounds. 4-Nitrobenzoic acid is also an inhibitor agent, which can be used for the recognition of the Mycobacterium tuberculosis complex and differentiation from non-tuberculous mycobacteria .

HY-W353258

Moxifloxacin hydrochloride monohydrate 20+ Cited Publications BAY 12-8039 monohydrate	Biochemical Assay Reagents
Moxifloxacin (BAY 12-8039) hydrochloride monohydrate is an orally active bacterial inhibitor that is effective against Streptococcus pneumoniae. Moxifloxacin hydrochloride monohydrate can be used in tuberculosis research .

HY-W145657

Trehalose 6,6′-dimycolate

Cord Factor

Biochemical Assay Reagents

Trehalose 6,6'-dimycolate (Cord Factor) is trehalose 6,6'-dimycolate, a cell wall glycolipid of Mycobacterium tuberculosis, which can be used to simulate inflammation and granuloma induced by Mycobacterium tuberculosis (MTB) form. Trehalose 6,6′-dimycolate also protects Mycobacterium tuberculosis from macrophage-mediated killing, inhibits efficient antigen presentation, and reduces the development of protective T cell responses .

HY-Y0030A

3-Hydroxypicolinic acid, matrix substance for MALDI-MS

3-HPA

Biochemical Assay Reagents

3-Hydroxypicolinic acid, matrix substance for MALDI-MS is a matrix. 3-Hydroxypicolinic acid, matrix substance for MALDI-MS coordinates with metal ions such as copper to form complexes with cytotoxic and antimycobacterial activity. 3-Hydroxypicolinic acid, matrix substance for MALDI-MS is used for the analysis of oligodeoxynucleotides in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). 3-Hydroxypicolinic acid, matrix substance for MALDI-MS is useful for nucleic acid analysis and anti-tuberculosis compound development .

HY-W110910

Eriochrome black T, Indicator

Biochemical Assay Reagents

Eriochrome black T, Indicator is a complexing agent for metal ions (e.g., Ca ²⁺, Mg ²⁺) and is used as an indicator in complexometric titrations. Eriochrome black T, Indicator forms colored complexes with metal ions through covalent coordination bonds, and indicates the endpoint of the titration by color change. Eriochrome black T, Indicator can be used as an anionic azo dye in photocatalytic degradation studies to evaluate the performance of photocatalysts. The reaction solution of Eriochrome black T, Indicator combined with Mg ²⁺ is initially purple. During loop-mediated isothermal amplification (LAMP), the color changes from purple to sky blue due to the consumption of Mg ²⁺ by the formation of magnesium pyrophosphate, indicating a positive reaction. The optimal concentration of Eriochrome black T, Indicator in LAMP is 60 μM, and the detection limit for Mycobacterium tuberculosis is 1 pg DNA/reaction .

HY-W007359

Thiomorpholine	Biochemical Assay Reagents
Thiomorpholine is an analogue of morpholine, can be used in various applications including synthesis .

HY-40156

5-Fluoroindole

Biochemical Assay Reagents

5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC₅₀ of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker .

HY-20457G

TL8-506	Biochemical Assay Reagents
TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC₅₀ of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy .

HY-NP022

Mycobacterium bovis bacterial protein Bacillus tuberculosis bovis	Biochemical Assay Reagents
Mycobacterium bovis bacterial protein is a member of the Mycobacterium tuberculosis complex. Mycobacterium bovis bacterial protein causes tuberculosis in bovines .

HY-W353258R

Moxifloxacin hydrochloride monohydrate (Standard)

BAY 12-8039 monohydrate (Standard)

Biochemical Assay Reagents

Moxifloxacin hydrochloride (BAY 12-8039) monohydrate (Standard) is the analytical standard of Moxifloxacin hydrochloride monohydrate. This product is intended for research and analytical applications. Moxifloxacin hydrochloride monohydrate is a blood-brain barrier-permeable, orally active topoisomerase II/IV inhibitor and a fluoroquinolone antibiotic. Moxifloxacin hydrochloride monohydrate disrupts bacterial DNA replication, transcription, repair and chromosome segregation processes. Moxifloxacin hydrochloride monohydrate exhibits activity against Gram-positive bacteria, Gram-negative bacteria, anaerobes, atypical pathogens, drug-resistant respiratory pathogens, Mycobacterium tuberculosis, mycoplasmas and Ureaplasma urealyticum.

Cat. No.	Product Name	Target	Research Area

HY-P5623

RVG 1 Publications Verification RVG29; RDP; Rabies Virus Glycoprotein-29	Bacterial	Infection
RVG (RVG29) is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-P6312

ESAT6 Epitope	MHC	Inflammation/Immunology
ESAT6 Epitope is a ESAT6 CD4 ⁺ T cell epitope. ESAT6 Epitope binds to MHC class I molecules with an IC₅₀ value of approximately 180 nM. ESAT6 Epitope has weak immunogenicity. ESAT6 Epitope can be used in studies related to pulmonary tuberculosis .

HY-P4284

Z-GGF-CMK	Proteasome ClpP Bacterial	Infection
Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC₅₀ of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC₅₀ of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis .

HY-125576

Griselimycin	Bacterial	Infection
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria .

HY-P3270

Capreomycin	Bacterial Antibiotic	Infection
Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation

HY-P5623B

RVG TFA 1 Publications Verification RVG29 TFA; RDP TFA; Rabies Virus Glycoprotein-29 TFA	Bacterial	Infection
RVG TFA is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-P11498

Cyclomarin monomer-2	Drug Intermediate Bacterial	Infection
Cyclomarin monomer-2 (Compound 10), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-2 binds to the Mtb ClpC1 protein with a K_D of 4.0 nM. The MIC of Cyclomarin monomer-2 against the Mtb H37Rv standard strain is 3.1 μM. Cyclomarin monomer-2 can be used as a key intermediate in the development of Homo-BacPROTACs .

HY-P11497

Cyclomarin monomer-1	Drug Intermediate Bacterial	Infection
Cyclomarin monomer-1 (Compound 5), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-1 binds to the Mtb ClpC1 protein with a K_D of 3.5 nM. The MIC of Cyclomarin monomer-1 against the Mtb H37Rv standard strain is 1.6 μM. Cyclomarin monomer-1 can be used as a key intermediate in the development of Homo-BacPROTACs .

HY-B2077

Enviomycin Tuberactinomycin N	Bacterial Antibiotic	Infection
Enviomycin (Tuberactinomycin N) is a antibacterial antibiotic. Enviomycin has been used to research chronic cavitary pulmonary tuberculosis .

HY-P3473

Evybactin	Bacterial DNA/RNA Synthesis	Infection
Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity .

HY-P0263R

Dermaseptin (Standard)	Reference Standards Bacterial Fungal Antibiotic	Infection
Kanamycin (sulfate) (Standard) is the analytical standard of Kanamycin (sulfate). This product is intended for research and analytical applications. Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16566A

Kanamycin sulfate 25+ Cited Publications Kanamycin A sulfate	Anti-inflammation/Immunoregulatory Classification of Application Fields Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields Source Classification	Bacterial Antibiotic
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

HY-N0262

Cordycepin 10+ Cited Publications 3'-Deoxyadenosine	Infection Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification Cancer	TNF Receptor MMP Bacterial Autophagy Antibiotic
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

HY-B1906

Streptomycin Maximum Cited Publications 46 Publications Verification Agrept; Agrimycin; Streptomycin A	Microorganisms Source Classification	Environmental Pollutants Antibiotic Bacterial
Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

HY-B0030

D-Cycloserine 5+ Cited Publications	Structural Classification Microorganisms Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Source Classification	iGluR Bacterial Antibiotic
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes, with blood-brain barrier permeability. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-N2033

Chebulinic acid 3 Publications Verification	Infection Classification of Application Fields Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-B1907

Rifamycin sodium 2 Publications Verification Rifamycin SV sodium	Infection Microorganisms Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial DNA/RNA Synthesis
Rifamycin sodium (Rifamycin SV monosodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .

HY-17566

Capreomycin sulfate 5 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease .

HY-B0271

Pyrazinamide 4 Publications Verification Pyrazinecarboxamide; Pyrazinoic acid amide	Source Classification	Bacterial Autophagy Antibiotic
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-113289

Brassicasterol 1 Publications Verification	Infection Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Akt Androgen Receptor Bacterial Drug Metabolite HSV
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-B0276

Ethionamide 5 Publications Verification 2-Ethylthioisonicotinamide	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity .

HY-N0732

Jolkinolide B 1 Publications Verification	Structural Classification Euphorbia fischeriana Steud. Classification of Application Fields Terpenoids Diterpenoids Euphorbiaceae Plants Disease Research Fields Cancer	IAP Akt Caspase NF-κB TGF-beta/Smad JAK Bacterial Apoptosis
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP, cIAP1, cIAP2, and phosphorylated Akt, upregulates Smac, activates caspase-3 and caspase-9, and inhibits NF-κB, TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis, suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis. Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis .

HY-N0591

Dehydrocostus Lactone 2 Publications Verification (-)-Dehydrocostus lactone; Epiligulyl oxide	Saussurea costus (Falc.) Lipsch. Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Cancer	Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .

HY-N0941

beta-Mangostin 4 Publications Verification β-Mangostin	Infection Xanthones Classification of Application Fields Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Disease Research Fields Source Classification Cancer	Bacterial Parasite Apoptosis
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

HY-B1122

L-Cycloserine 2 Publications Verification (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	Microorganisms Neurological Disease Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	GABA Receptor HIV
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains .

HY-W010589

L-2-Aminobutyric acid H-Abu-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
L-2-Aminobutyric acid (H-Abu-OH) is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.

HY-125365

Rifamycin S 2 Publications Verification	Infection Quinones Structural Classification Monophenols Microorganisms Classification of Application Fields Phenols Naphthalene Quinones Disease Research Fields Source Classification	Bacterial Reactive Oxygen Species (ROS) Antibiotic
Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy .

HY-N2547

Steviolbioside 1 Publications Verification	Trifolium hybridum L. Classification of Application Fields Terpenoids Diterpenoids Plants Compositae Disease Research Fields Sweeteners Source Classification Cancer Food Research	Drug Intermediate Bacterial
Steviolbioside is a sweetener and also an important pharmaceutical intermediate. Steviolbioside can inhibit the proliferation of various tumor cells. Steviolbioside has an MIC of 3.8 µg/mL for Mycobacterium tuberculosis. Steviolbioside also has antidiabetic activity. Steviolbioside can be used in the research of tuberculosis, diabetes and tumors such as breast cancer .

HY-N1887

4-Allylcatechol 1 Publications Verification Hydroxychavicol; 4-Allylpyrocatechol	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Bacterial Antibiotic TNF Receptor Interleukin Related
4-Allylcatechol (4-Allylpyrocatechol) is a xylan which has oral activity and can be isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC₅₀ = 5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC = 27.6 μg/mL) .

HY-Y0030

3-Hydroxypicolinic acid 3-hydroxypyridine-2-carboxylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Biochemical Assay Reagents Drug Intermediate
3-Hydroxypicolinic acid is a heterocyclic carboxylic acid ligand and cytotoxin, with a MIC₉₀ of >25 μg/mL against Mycobacterium tuberculosis H37Rv. 3-Hydroxypicolinic acid inhibits the growth of cancer cells and normal fibroblasts. 3-Hydroxypicolinic acid is applicable to research related to chronic myeloid leukemia, human lung adenocarcinoma, and tuberculosis .

HY-N15574

Saringosterol	Structural Classification Marine algae Marine natural products Steroids Source Classification	LXR Bacterial PPAR
Saringosterol is an orally active steroid found in Sargassum muticum. Saringosterol is a LXR agonist. Saringosterol can lower cholesterol levels and inhibit the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα). Saringosterol has anti-obesity, anti-atherosclerosis, anti-Mycobacterium tuberculosis and anti-depressant activities .

HY-N1976

(+)-(3R,8S)-Falcarindiol 1 Publications Verification (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol	Infection Structural Classification Natural Products Classification of Application Fields Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification
(+)-(3R,8S)-Falcarindiol ((3R,8S)-Falcarindiol; 3 (R),8 (S),9 (Z)-Falcarindiol) is an orally active polyacetylene anti-mycobacterial agent. (+)-(3R,8S)-Falcarindiol exhibits antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and mycobacteria. Co-administration of (+)-(3R,8S)-Falcarindiol with (3R)-falcarinol alters the composition of gut microbiota, reduces colonic tumor lesions and slows down polyp growth. (+)-(3R,8S)-Falcarindiol can be used in research related to tuberculosis and colorectal cancer .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Structural Classification other families Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Source Classification Cancer	Interleukin Related DNA/RNA Synthesis Reactive Oxygen Species (ROS) Topoisomerase
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-N6005

Methyl caffeate	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Solanum torvum Swartz Phenylpropanoids Solanaceae Plants Disease Research Fields Source Classification	Bacterial Fungal Apoptosis Bcl-2 Family
Methyl caffeate is a phenylpropanoid, antibacterial agent, and Apoptosis-inducing agent. Methyl caffeate can be isolated from the flowers of peach Prunus persica (L.). Methyl caffeate upregulates the expression of pro-apoptotic proteins Bid, Bax and p53, and downregulates the expression of anti-apoptotic protein BCL-2. Methyl caffeate downregulates SASP factors. Methyl caffeate enhances glucose-stimulated insulin secretion. Methyl caffeate inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, fungi, and Mycobacterium tuberculosis strains. Methyl caffeate can be used in studies related to breast cancer, type 2 diabetes, and tuberculosis .

HY-W005327

1-Hydroxy-2-butanone	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Drug Intermediate
1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice. 1-Hydroxy-2-butanone acts as a key intermediate for ethambutol. Ethambutol has anti-tuberculosis effects .

HY-N2208

4-Hydroxylonchocarpin 2 Publications Verification	Classification of Application Fields Metabolic Disease Plants Infection Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK Apoptosis Reactive Oxygen Species (ROS)
4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces reactive oxygen species (ROS) and apoptosis in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities .

HY-N8060A

Orotidine 5′-monophosphate trisodium 1 Publications Verification Orotidine monophosphate trisodium; Orotidylic acid trisodium	Alkaloids Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite DNA/RNA Synthesis
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .

HY-N15643

α-Mycolic acid (C80) α-MA (C80)	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
α-Mycolic acid (C80) is a structural lipid component of mycobacterial cell wall. α-Mycolic acid (C80) can be isolated from Mycobacterium tuberculosis Canetti. α-Mycolic acid (C80) significantly modulates membrane permeability and stability, promising for mycobacterium tuberculosis infection research .

HY-N11722

Panduratin A	Structural Classification Phenols Polyphenols Boesenbergia rotunda Plants Source Classification Zingiberaceae	Apoptosis NF-κB Keap1-Nrf2 AMPK Autophagy SARS-CoV DNA Methyltransferase
Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2 .

HY-N8343

Arjunglucoside I	Triterpenes Terpenoids Plants Fagaceae Speranskia tuberculata (Bunge) Baill. Source Classification	Bacterial
Arjunglucoside I, a natural compound, possesses antimicrobial activity with a MIC of 1.9 μg/mL .

HY-B0271R

Pyrazinamide (Standard) Pyrazinecarboxamide (Standard); Pyrazinoic acid amide (Standard)	Microorganisms Source Classification	Reference Standards Bacterial Autophagy Antibiotic
Pyrazinamide (Standard) is the analytical standard of Pyrazinamide. This product is intended for research and analytical applications. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-B1906R

Streptomycin (Standard) Agrept (Standard); Agrimycin (Standard); Streptomycin A (Standard)	Microorganisms Source Classification	Reference Standards Antibiotic Bacterial
Streptomycin (Standard) is the analytical standard of Streptomycin. This product is intended for research and analytical applications. Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

HY-B0030R

D-Cycloserine (Standard) 5+ Cited Publications	Infection Microorganisms Neurological Disease Classification of Application Fields Antibiotics Endogenous metabolite Disease Research Fields Beta-lactam Antibiotics Source Classification	Reference Standards iGluR Bacterial Antibiotic
D-Cycloserine (Standard) is the analytical standard of D-Cycloserine. This product is intended for research and analytical applications. D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-N0262R

Cordycepin (Standard) 3'-Deoxyadenosine (Standard)	Structural Classification Natural Products Microorganisms Source Classification	TNF Receptor Reference Standards MMP Bacterial Autophagy Antibiotic
Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

HY-N15645

α-Mycolic acid, keto cis	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
α-Mycolic acid, keto cis is a structural lipid component of mycobacterial cell wall. α-Mycolic acid, keto cis can be isolated from Mycobacterium tuberculosis Canetti. α-Mycolic acid, keto cis significantly modulates membrane permeability and stability, promising for mycobacterium tuberculosis infection research .

HY-16566R

Kanamycin (Standard) Kanamycin A (Standard)	Microorganisms Source Classification	Reference Standards Antibiotic Bacterial
Kanamycin (Standard) is the analytical standard of Kanamycin. This product is intended for research and analytical applications. Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].

HY-B0276R

Ethionamide (Standard) 2-Ethylthioisonicotinamide (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic
Ethionamide (Standard) is the analytical standard of Ethionamide. This product is intended for research and analytical applications. Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic.

HY-126597

Chaetoglobosin C	Alkaloids Microorganisms Indole Alkaloids Source Classification	Bacterial
Chaetoglobosin C (Compound 4) is a anthraquinone-chromone compound derived from the fungus Chaetomium globosum KMITL-N0802. Chaetoglobosin C has anti-tuberculosis activity .

HY-N8624

Ethyl 3,4-dicaffeoylquinate	Phenols Polyphenols Plants Compositae Desmodium uncinatum DC. Source Classification	Bacterial
Ethyl 3,4-dicaffeoylquinate is a phenolic acid isolated from G. divaricata. G. divaricata is one of the famous traditional Chinese herbs, usually used for bronchitis, tuberculosis, twisted knot cough, rheumatism, diabetes, etc .

HY-111402

Pyridomycin Erizomycin; NSC 246134	Natural Products Microorganisms Source Classification	Bacterial Antibiotic
Pyridomycin (Erizomycin) is a selective and low cytotoxic inhibitor of Mycobacterium tuberculosis that effectively targets InhA. Pyrdomycin is also an antibiotic that can be obtained from metabolites of Dactylosporangium fulvum. Pyrdomycin can be used in the study of bacterial infections such as tuberculosis .

HY-131597

8-Oxo-GTP 8-Hydroxyguanosine triphosphate	Source Classification	Reactive Oxygen Species (ROS)
8-Oxo-GTP is an oxidized guanine nucleotide, produced by reactive oxygen species (ROS). 8-Oxo-GTP serves as a substrate for MutT protein, GTP cyclohydrolase II, Mycobacterium tuberculosis MutT1, and Mycobacterium tuberculosis Rv1700, which hydrolyze it to corresponding nucleoside monophosphates or diphosphates. 8-Oxo-GTP causes detrimental effects including mutations and mistranslation when incorporated into nucleic acids. 8-Oxo-GTP can be used for the research of cancer and tuberculosis .

HY-W012813

2-Acetyl-5-methylfuran	Cinnamomum kotoense Kaneh. & Sasaki Structural Classification Ketones, Aldehydes, Acids Plants Lauraceae Source Classification	Bacterial
2-Acetyl-5-methylfuran is a growth inhibitor of Mycobacterium tuberculosis, exhibiting an in vitro anti-tubercular activity with an MIC of 322.58 μM. 2-Acetyl-5-methylfuran demonstrates high safety and can be used for research related to tuberculosis .

HY-N3700

Decarine Rutaceline	Structural Classification Alkaloids Rutaceae Plants Isoquinoline Alkaloids Zanthoxylum simulans Hance Source Classification	Bacterial HIV TNF Receptor Interleukin Related
Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection .

HY-N3612

Communic acid (+)-Communic acid	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial Akt MMP
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging .

HY-126640

Phomoxanthone A	Quinones Microorganisms Anthraquinones Source Classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N11259

Sophoradiol	Triterpenes Structural Classification Leguminosae Terpenoids Abrus precatorius Linn. Plants Source Classification	Bacterial
Sophoradiol is a triterpenoid compound that can be extracted from Abrus Precatorius. Sophoradiol is an orally effective anti-tuberculosis agent. Sophoradiol has inhibitory activity against various strains of Mycobacterium tuberculosis. Sophoradiol has good biocompatibility. Sophoradiol can be used in the research of tuberculosis .

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	Lignans Phenylpropanoids Plants Lauraceae Lindera akoensis Hay. Source Classification	p38 MAPK AP-1 Bacterial
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv .

HY-N11048

Amycolatopsin A	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Disease Research Fields Cancer Source Classification	Bacterial
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

HY-N2547R

Steviolbioside (Standard)	Structural Classification Trifolium hybridum L. Terpenoids Diterpenoids Plants Compositae Source Classification	Reference Standards Drug Intermediate Bacterial
Steviolbioside (Standard) is the analytical standard of Steviolbioside (HY-N2547). This product is intended for research and analytical applications. Steviolbioside is a sweetener and also an important pharmaceutical intermediate. Steviolbioside can inhibit the proliferation of various tumor cells. Steviolbioside has an MIC of 3.8 µg/mL for Mycobacterium tuberculosis. Steviolbioside also has antidiabetic activity. Steviolbioside can be used in the research of tuberculosis, diabetes and tumors such as breast cancer .

HY-N2876

Anisofolin A	Monophenols Flavonoids Flavones Labiatae Phenols Plants Artemisia persica Boiss. Source Classification	Parasite Bacterial
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC₅₀: 4.39 μM), and antimycobacterium activity (IC₅₀: 4.50 μM) against M. tuberculosis H37Ra .

HY-N15644

Mycolic acid IIa	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Mycolic acid IIa is a structural lipid component of mycobacterial cell wall. Mycolic acid IIa can be isolated from Mycobacterium bovis BCG. Mycolic acid IIa significantly modulates membrane permeability and stability, promising for mycobacterium tuberculosis infection research .

Tag:	His (7) Strep (1) Tag Free (6) Myc (1)
Source:	Sf9 insect cells (1) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703441

	treS Protein, Mycobacterium tuberculosis Trehalose synthase/amylase TreS; Maltose alpha-D-glucosyltransferase; MTase; treS; Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); Glycosidase; Hydrolase; Isomerase; 3.2.1.1	Others	E. coli
	treS Protein, Mycobacterium tuberculosis is the recombinant treS, expressed by E. coli , with tag Free labeled tag. ,

HY-P703442

	icl1 Protein, Mycobacterium tuberculosis Isocitrate lyase 1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; 4.1.3.30; icl1; Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh); Lyase; 4.1.3.1	Others	E. coli
	icl1 Protein, Mycobacterium tuberculosis is the recombinant icl1, expressed by E. coli , with tag Free labeled tag.

HY-P703425

	serB2 Protein, Mycobacterium tuberculosis Phosphoserine phosphatase SerB2; O-phosphoserine phosphohydrolase; Protein-serine/threonine phosphatase; 3.1.3.16; serB2; Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); Hydrolase; 3.1.3.3	Others	E. coli
	serB2 Protein, Mycobacterium tuberculosis is the recombinant serB2, expressed by E. coli , with tag Free labeled tag. ,

HY-P701867

	ClpC1 NTD Protein, Mycobacterium tuberculosis clpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1	Others	E. coli
	ClpC1 NTD Protein, the ATP-dependent specificity component of the Clp protease, directs the protease to specific substrates and exhibits chaperone functions independently of ClpP. It plays a crucial role in the targeted degradation of substrates, such as the anti-sigma-E factor RseA, in the presence of ClpP2. ClpC1 NTD Protein, Mycobacterium tuberculosis is the recombinant ClpC1 NTD protein, expressed by E. coli , with tag free.

HY-P702605

	*CFP-10 Protein, Mycobacterium tuberculosis* (His)** esxB; cfp10; lhp; mtsA10; MT3988ESAT-6-like protein EsxB; 10 kDa culture filtrate antigen CFP-10; Secreted antigenic protein MTSA-10; Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	Others	E. coli
	CFP-10 Protein, Mycobacterium tuberculosis (His) is the recombinant CFP-10, expressed by E. coli , with N-6*His labeled tag.

HY-P701868

	*ClpC1 NTD Protein, Mycobacterium tuberculosis* (His)** clpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1	Others	E. coli
	ClpC1 NTD Protein, the ATP-dependent specificity component of the Clp protease, directs the protease to specific substrates and exhibits chaperone functions independently of ClpP. It plays a crucial role in the targeted degradation of substrates, such as the anti-sigma-E factor RseA, in the presence of ClpP2. ClpC1 NTD Protein, Mycobacterium tuberculosis (His) is the recombinant ClpC1 NTD protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702796

	*EsxA Protein, Mycobacterium tuberculosis* (His, Myc)** esxA; esaT6; BQ2027_MB39056 kDa early secretory antigenic target; ESAT-6	Others	E. coli
	EsxA Protein, Mycobacterium tuberculosis (His, Myc) is the recombinant EsxA, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P703426

	*kshA Protein, Mycobacterium tuberculosis* (His, Strep)** 3-ketosteroid-9-alpha-monooxygenase, oxygenase component; 3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; RO; kshA; Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); Oxidoreductase;	Others	E. coli
	kshA Protein, Mycobacterium tuberculosis (His, Strep) is the recombinant kshA, expressed by E. coli , with Strep, His labeled tag. ,

HY-P701958

	PBP1A Protein, Mycobacterium tuberculosis ponA1; Penicillin-binding protein 1A; PBP-1A; Penicillin-binding protein 1*; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase	Others	E. coli
	PBP1A (penicillin-binding protein 1A) is involved in cell wall formation and plays a crucial role in the synthesis of cross-linked peptidoglycan from lipid intermediates. The enzyme has a bifunctional structure. The penicillin-insensitive transglycosylase N-terminal domain is responsible for the formation of linear glycan chains, and the penicillin-sensitive transpeptidase C-terminal domain promotes the cross-linking of peptide subunits. PBP1A Protein, Mycobacterium tuberculosis is the recombinant PBP1A protein, expressed by E. coli , with tag free.

HY-P701959

	*PBP1A Protein, Mycobacterium tuberculosis* (His)** ponA1; Penicillin-binding protein 1A; PBP-1A; Penicillin-binding protein 1*; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase	Others	E. coli
	PBP1A (penicillin-binding protein 1A) is involved in cell wall formation and plays a crucial role in the synthesis of cross-linked peptidoglycan from lipid intermediates. The enzyme has a bifunctional structure. The penicillin-insensitive transglycosylase N-terminal domain is responsible for the formation of linear glycan chains, and the penicillin-sensitive transpeptidase C-terminal domain promotes the cross-linking of peptide subunits. PBP1A Protein, Mycobacterium tuberculosis (His) is the recombinant PBP1A protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701979

	kshB Protein, Mycobacterium tuberculosis hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis is the recombinant kshB protein, expressed by E. coli , with tag free.

HY-P701980

	*kshB Protein, Mycobacterium tuberculosis* (His)** hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis (His) is the recombinant kshB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72049

	*CYP51 Protein, Mycobacterium tuberculosis* (sf9, His)** cyp51; MT0788Lanosterol 14-alpha demethylase; EC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase	Others	Sf9 insect cells
	CYP51 Proteinas is a sterol 14α-demethylase that acts with an unknown physiological substrate and accepts electrons from the iron-sulfur ferredoxin Fdx. In vitro, it catalyzes the C14-demethylation of lanosterol, 24,25-dihydrolanosterol, and obtanyol, showing stereoselectivity in producing 8,14-diene. CYP51 Protein, Mycobacterium tuberculosis (sf9, His) is the recombinant CYP51 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-14881S1

(Rac)-Bedaquiline-d6
(Rac)-Bedaquiline-d6 is the deuterium labeled Bedaquiline (HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-B0271S

Pyrazinamide-d3
Pyrazinamide-d₃ is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis .

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-W654329

Protionamide-d7
Protionamide-d₇ is deuterium labeled Prothionamide. Protionamide (prothionamide) acts on tuberculosis and leprosy .

HY-10844S

Pretomanid-d4
Pretomanid-d₄ is the deuterium labeled Pretomanid. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL .

HY-B0271S1

Pyrazinamide-13C,15N
Pyrazinamide- ¹³C, ¹⁵N is ¹⁵N and ¹³C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-B0269S

Rifapentine-d9
Rifapentine-d₉ is the deuterium labeled Rifapentine. Rifapentine (DL 473) is an antibiotic compound used in the treatment of tuberculosis.

HY-B0306S

Prothionamide-d5

Prothionamide-d₅ is deuterium labeled Prothionamide (HY-B0306). Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a K_m value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy .

HY-134940S

Quabodepistat-d7
Quabodepistat-d₇ (OPC-167832-d₇) is deuterium labeled Quabodepistat. Quabodepistat (OPC-167832) is a potent and orally active dprE1 inhibitor with?an IC₅₀ of 0.258 μM. Quabodepistat has antituberculosis activity and can be used for the research of tuberculosis?caused by?Mycobacterium tuberculosis .

HY-14881S2

Bedaquiline impurity 2-d6
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-B0276S

Ethionamide-d3
Ethionamide-d₃ is the deuterium labeled Ethionamide. Ethionamide (2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis.

HY-W739149

Rifapentine-d8
Rifapentine-d₈ is deuterium labeled Rifapentine. Rifapentine (DL 473) is an antibiotic used in tuberculosis research .

HY-W018677S

Quinoxaline-d4
Quinoxaline-d₄ is the deuterium labeled Quinoxaline . Quinoxaline is a chemical compound that acts as an intermediate for anti-tuberculosis agent Pyrazinamide. Quinoxaline presents a structure that is similar to quinolone antibiotics .

HY-W702303

Terizidone-15N2,d6
Terizidone- ¹⁵N₂,d₆ is the deuterium and ¹⁵N-labeled Terizidone (HY-112324). Terizidone is an antibacterial agent, and shows bacteriostatic activity. Terizidone can be used in tuberculosis (TB) research .

HY-W013186S

Lansoprazole sulfide-d4
Lansoprazole sulfide-d₄ is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC₅₀ values of 0.59 μM intracellularly and 0.46 μM in broth .

HY-B1355AS

Oxyphenbutazone-d9
Oxyphenbutazone-d₉ is the deuterium labeled Oxyphenbutazone (HY-B1355A). Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230). Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis .

HY-B1355AS1

Oxyphenbutazone-13C6
Oxyphenbutazone- ¹³C₆ is the ¹³C₆ labeled Oxyphenbutazone (HY-B1355A). Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230). Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis .

HY-10392S

Sutezolid-13C4
Sutezolid- ¹³C₄ (PNU-100480- ¹³C₄) is ¹³C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-W010589S2

L-2-Aminobutyric acid-d6

L-2-Aminobutyric acid-d₆ is the deuterium labeled L-2-Aminobutyric acid. L-2-Aminobutyric acid is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.

HY-W010589S

L-2-Aminobutyric acid-d3

L-2-Aminobutyric acid-d₃ is the deuterium labeled L-2-Aminobutyric acid. L-2-Aminobutyric acid is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.

Cat. No.	Product Name		Classification

HY-153808

Complete Freund's adjuvant (CFA) Maximum Cited Publications 15 Publications Verification		Adjuvant
Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .

HY-153808A

Incomplete Freund's adjuvant (IFA) 4 Publications Verification		Adjuvant
Incomplete Freund's adjuvant (IFA) (Montanide ISA-51) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund. Incomplete Freund's adjuvant (IFA) does not contain inactivated tuberculosis bacilli and consists of petroleum jelly containing lanolin. Incomplete Freund's adjuvant (IFA) induces high antibody titers and long-lasting effector T cell responses with no long-term effects on collagen disease, tumors, or death. Complete Freund's adjuvant (CFA) (HY-153808) is another type of Freund's Adjuvant that stimulates a stronger immune response .

HY-153808B

Complete Freund's adjuvant (CFA, 1 mg/ml)		Adjuvant
Complete Freund's adjuvant (CFA, 1 mg/ml) is an immunoadjuvant emulsified with antigen that can enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA, 1 mg/ml) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA, 1 mg/ml) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA, 1 mg/ml) stimulates a strong and durable immune response and can be used to induce rheumatoid arthritis in rats, and more .

HY-113289

Brassicasterol 1 Publications Verification		Cholesterol
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-177889

Sal-AMP		Nucleotide Analogs
Sal-AMP is an acyl-adenylate intermediate. Sal-AMP can be loaded by MbtA on to the thiolation domain of MbtB. Sal-AMP can be used in tuberculosis research .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-20457G

TL8-506	Toll-like Receptor (TLR) Bacterial Interleukin Related	Inflammation/Immunology Cancer
TL8-506 (GMP) is TL8-506 (HY-20457) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TL8-506 is a specific TLR8 agonist with an EC₅₀ of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy .

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