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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
tumor stroma
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "tumor stroma" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P71436
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ZBP1; Z‑DNA Binding Protein 1; alias:C20orf183; DLM1; DAI; tumor stroma And Activated Macrophage Protein DLM‑1; Z‑DNA‑Binding Protein 1; DLM‑1; DNA‑Dependent Activator Of IRFs; DJ718J7.3; DNA‑Dependent Activator Of IFN‑Regulatory Factors; Chromosome 20 Op
Species:
Human
Source:
E. coli
1
1
1 Cited Publications
Cat. No.: HY-P10869
Research Areas:
Cat. No.: HY-P4111
CAS No.: 1318232-11-9
Target:
Research Areas:
Cat. No.: HY-170779
CAS No.: 3078291-78-5
DOTA-NI-FAPI-04 is a FAP inhibitor (IC50 = 7.44 nM). By integrating FAP targeting with hypoxia-sensitive groups (nitroimidazole), DOTA-NI-FAPI-04 significantly enhances tumor uptake and retention capabilities. DOTA-NI-FAPI-04 chelates metallic isotopes (such as 68Ga and 177Lu) through DOTA to produce radioactive probes ([68Ga]Ga/DOTA-NI-FAPI-04 and [177Lu]Lu/DOTA-NI-FAPI-04), which can be used for research in tumor diagnostics and therapeutic agents. DOTA-NI-FAPI-04 holds dual targeting potential in the fields of cancer imaging, tumor microenvironment analysis, and radionuclide therapy, particularly suitable for scenarios where the tumor stroma and hypoxic regions synergistically interact .
AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is an Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment .
Cat. No.: HY-134920
CAS No.: 2116519-76-5
Research Areas:
LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma .
Cat. No.: HY-185931
CAS No.: 3083163-26-9
Target:
Research Areas:
Romolisiran is a sulfotransferase 15 (CHST15) synthesis inhibitor. CHST15 is upregulated in fibrosis (lung, liver, kidney), tumor stroma and inflammation; chondroitin sulfate chains modified by its product participate in TGF-β activation, collagen cross-linking and fibroblast activation. Romolisiran can be used to study diseases associated with fibrosis/stromal modification .
Cat. No.: HY-187490A
Synonyms: DOPE-PEG2000-Mal-Cys-CREKA
Target:
Research Areas:
DOPE-PEG2000-CREKA (DOPE-PEG2000-Mal-Cys-CREKA) is an amphiphilic lipid-PEG-peptide conjugate consisting of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the CREKA peptide (Cys-Arg-Glu-Lys-Ala), a tumor-homing peptide identified by in vivo phage display. DOPE-PEG2000-CREKA is used for tumor stroma-targeted drug delivery.
Cat. No.: HY-187238A
Synonyms: DPPE-PEG2000-CSRNLIDC
Target:
Research Areas:
DPPE-PEG2000-pPB (DPPE-PEG2000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dipalmitoylphosphatidylethanolamine (DPPE) as the lipid anchoring group, PEG, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DPPE-PEG2000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187326C
Synonyms: DOPE-PEG5000-CSRNLIDC
Target:
Research Areas:
DOPE-PEG5000-pPB (DOPE-PEG5000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, PEG, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DOPE-PEG5000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187245A
Synonyms: DSG-PEG2000-CSRNLIDC
Target:
Research Areas:
DSG-PEG2000-pPB (DSG-PEG2000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: distearoylglycerol (DSG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DSG-PEG2000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187246
Synonyms: DMG-PEG1000-CSRNLIDC
Target:
Research Areas:
DMG-PEG1000-pPB (DMG-PEG1000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 1000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DMG-PEG1000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187246A
Synonyms: DMG-PEG2000-CSRNLIDC
Target:
Research Areas:
DMG-PEG2000-pPB (DMG-PEG2000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DMG-PEG2000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187246B
Synonyms: DMG-PEG3400-CSRNLIDC
Target:
Research Areas:
DMG-PEG3400-pPB (DMG-PEG3400-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 3400 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DMG-PEG3400-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187246C
Synonyms: DMG-PEG5000-CSRNLIDC
Target:
Research Areas:
DMG-PEG5000-pPB (DMG-PEG5000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 5000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DMG-PEG5000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187326
Synonyms: DOPE-PEG1000-CSRNLIDC
Target:
Research Areas:
DOPE-PEG1000-pPB (DOPE-PEG1000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 1000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DOPE-PEG1000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187326A
Synonyms: DOPE-PEG2000-CSRNLIDC
Target:
Research Areas:
DOPE-PEG2000-pPB (DOPE-PEG2000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DOPE-PEG2000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
Cat. No.: HY-187326B
Synonyms: DOPE-PEG3400-CSRNLIDC
Target:
Research Areas:
DOPE-PEG3400-pPB (DOPE-PEG3400-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 3400 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DOPE-PEG3400-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
