1126366-36-6
1126366-36-6
Chemical Structure
AZD8542
- CAS No.: 1126366-36-6
- Formula:C25H24N4O2
- Molecular Weight:412.48
IUPAC Name: N-(2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl)-4-(pyridin-2-ylmethoxy)benzamide
InChIKey: SMQVBAGSZVHCJP-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)OCC2=NC=CC=C2)NC3=CC(C4=CN(C)C=N4)=C(C)C=C3C
Biological Activity: AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is an Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment[1][2].
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AZD8542 | 99.49% | AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is an Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment. | ||||||||||||||||||||
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References
- [1]. Rosa F. Hwang, INHIBITION OF THE HEDGEHOG PATHWAY TARGETS THE TUMOR-ASSOCIATED STROMA IN PANCREATIC CANCER. Mol Cancer Res. 2012 Sep; 10(9): 1147–1157.
- [2]. Dakin Leslie, et al. Preparation of amide compounds containing heterocycle moiety as hedgehog pathway inhibitors. World Intellectual Property Organization, WO2009027746 A1
Keywords
