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Cat. No.: HY-170779

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DOTA-NI-FAPI-04

Name: DOTA-NI-FAPI-04
Brand: MedChemExpress
SKU: HY-170779
Price: 470.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

DOTA-NI-FAPI-04 is a FAP inhibitor (IC₅₀ = 7.44 nM). DOTA-NI-FAPI-04 significantly enhances tumor uptake and retention capacity by integrating FAP targeting with a hypoxia-sensitive group (nitroimidazole). DOTA-NI-FAPI-04 chelates metal isotopes via DOTA to generate radioactive probes (such as [⁶⁸Ga]Ga/DOTA-NI-FAPI-04 and [¹⁷⁷Lu]Lu/DOTA-NI-FAPI-04), which can be used for cancer imaging and tumor diagnosis-related research.

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CAS No.: 3078291-78-5
Formule: C₅₁H₆₉F₂N₁₅O₁₄
Masse moléculaire:1154.18

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

DOTA-NI-FAPI-04 Chemical Structure

CAS No.: 3078291-78-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
Help & FAQs
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Bioz

Activité biologique

Description

IC₅₀ & Target

FAP

7.44 nM (IC₅₀)

In Vitro

DOTA‑NI‑FAPI‑04 (compound 1) exhibits FAP binding affinity in HT1080‑FAP cells (IC₅₀ = 7.44 nM)^[1].
DOTA-NI-FAPI-04 shows rapid FAP-specific uptake and internalization in HT1080-FAP cells, with the ⁶⁸Ga-labeled form reaching 25.97% ID/(7 × 10⁵ cells) at 90 min and the ¹⁷⁷Lu-labeled form reaching 49.68% ID/(7 × 10⁵ cells)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DOTA-NI-FAPI-04, after radiolabeling with ⁶⁸Ga or ¹⁷⁷Lu, shows high tumor uptake and retention in U87MG xenograft tumors^[1].
DOTA‑NI‑FAPI‑04 yields [⁶⁸Ga]Ga‑DOTA‑NI‑FAPI‑04 radiotracer that achieves high SUV_max values in primary tumors, lymph node metastases, bone metastases and liver metastases of human subjects^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3078291-78-5
Masse moléculaire 1154.18
Formule C₅₁H₆₉F₂N₁₅O₁₄
SMILES

O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(N[C@@H](CCC(NCCCN2C=CN=C2[N+]([O-])=O)=O)C(N3CCN(CCCOC4=CC=C(C5=C4)N=CC=C5C(NCC(N6[C@@H](CC(F)(C6)F)C#N)=O)=O)CC3)=O)=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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2025 Nov 26.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Luo Y, et al. Development of [68Ga]Ga/[177Lu]Lu-DOTA-NI-FAPI-04 Containing a Nitroimidazole Moiety as New FAPI Radiotracers with Improved Tumor Uptake and Retention. Journal of Medicinal Chemistry. 2025;68(1):348-360.

[2]. Zang J, et al. First-in-human study of a novel bifunctional PET tracer [Ga]Ga-DOTA-NI-FAPI-04 targeting FAP and hypoxia. European journal of nuclear medicine and molecular imaging. 2026 Mar;53(4):2530-2539.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

DOTA-NI-FAPI-04

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Pureté et documentation
Références

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DOTA-NI-FAPI-04

Publications Citing Use of MedChemExpress (MCE) DOTA-NI-FAPI-04