DOTA-NI-FAPI-04
Based on 1 publication(s) in Google Scholar
DOTA-NI-FAPI-04 is a FAP inhibitor (IC50 = 7.44 nM). DOTA-NI-FAPI-04 significantly enhances tumor uptake and retention capacity by integrating FAP targeting with a hypoxia-sensitive group (nitroimidazole). DOTA-NI-FAPI-04 chelates metal isotopes via DOTA to generate radioactive probes (such as [68Ga]Ga/DOTA-NI-FAPI-04 and [177Lu]Lu/DOTA-NI-FAPI-04), which can be used for cancer imaging and tumor diagnosis-related research.
For research use only. We do not sell to patients.
- CAS No.: 3078291-78-5
- Formula: C51H69F2N15O14
- Molecular Weight:1154.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) DOTA-NI-FAPI-04
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Biological Activity
Description
IC50 & Target
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FAP 7.44 nM (IC50) |
In Vitro
DOTA-NI-FAPI-04 shows rapid FAP-specific uptake and internalization in HT1080-FAP cells, with the 68Ga-labeled form reaching 25.97% ID/(7 × 105 cells) at 90 min and the 177Lu-labeled form reaching 49.68% ID/(7 × 105 cells)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
DOTA‑NI‑FAPI‑04 yields [68Ga]Ga‑DOTA‑NI‑FAPI‑04 radiotracer that achieves high SUVmax values in primary tumors, lymph node metastases, bone metastases and liver metastases of human subjects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3078291-78-5
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Molecular Weight 1154.18
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Formula C51H69F2N15O14
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SMILES
O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(N[C@@H](CCC(NCCCN2C=CN=C2[N+]([O-])=O)=O)C(N3CCN(CCCOC4=CC=C(C5=C4)N=CC=C5C(NCC(N6[C@@H](CC(F)(C6)F)C#N)=O)=O)CC3)=O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DOTA-NI-FAPI-04 Related Classifications
HY-170779 Related Classifications
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