2116519-76-5
Chemical Structure
LW106
- CAS No.: 2116519-76-5
- Formula:C11H11N5O2
- Molecular Weight:245.24
IUPAC Name: (Z)-(4-amino-1,2,5-oxadiazol-3-yl)(isoindolin-2-yl)methanone oxime
InChIKey: QHVIXMMITPHBSL-QBFSEMIESA-N
SMILES: O/N=C(N1CC2=C(C1)C=CC=C2)/C3=NON=C3N
Biological Activity: LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma[1].
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LW106 | LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma. | |||||||||||||||||||||
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Keywords
