1318232-11-9
Chemical Structure
Peptide R
- CAS No.: 1318232-11-9
- Formula:C39H57N13O8S2
- Molecular Weight:900.08
IUPAC Name: (E)-N-(7-(3-((tert-butyldimethylsilyl)oxy)propoxy)-5-carbamoyl-1-(4-(6-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamido)-3H-imidazo[4,5-b]pyridin-3-yl)but-2-en-1-yl)-1H-benzo[d]imidazol-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide
InChIKey: WOVYKVDSWWPJMK-ODKJCKIQSA-N
SMILES: O=C(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(O)=O)NC1=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H]1CC3=CC=CC=C3)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Biological Activity: Peptide R is a cyclic peptide and a specific CXCR4 antagonist. Peptide R exhibits excellent ability to effectively remodel tumor stroma. Peptide R has potential for use in tumor research[1][2].
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Peptide R | Peptide R is a cyclic peptide and a specific CXCR4 antagonist. Peptide R exhibits excellent ability to effectively remodel tumor stroma. Peptide R has potential for use in tumor research. | |||||||||||||||||||||
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References
- [1]. Le Joncour V, et al. Seek & Destroy, use of targeting peptides for cancer detection and drug delivery. Bioorg Med Chem. 2018;26(10):2797-2806. [Content Brief]
- [2]. Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016;35:55. Published 2016 Mar 25. [Content Brief]
