DOPE-PEG2000-CREKA

DOPE-PEG2000-CREKA: surface functionalization of liposomes and nanoparticles for tumor stroma-targeted drug delivery and tumor imaging, homing to clotting products in tumor extracellular matrix.
Structural composition:
(1) DOPE; a phospholipid with two unsaturated oleoyl chains that anchors into lipid bilayers and provides fusogenic activity for endosomal escape;
(2) PEG2000; a hydrophilic polymer that creates a steric shield reducing opsonization and RES clearance, prolonging circulation time;
(3) CREKA peptide; a tumor-homing pentapeptide identified by in vivo phage display that specifically binds to fibrin-fibronectin complexes deposited in tumor stroma as a result of occult tumor-associated blood coagulation, directing nanocarriers to tumor extracellular matrix; this targeting is unique to tumors as fibrin-fibronectin complexes are not present in normal tissues.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.