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Cat. No.: HY-155808

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STAT3-IN-18

STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.

For research use only. We do not sell to patients.

CAS No.: 2668267-41-0
Formula: C₁₈H₂₄Cl₂N₂O₆Pt
Molecular Weight:630.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

STAT3-IN-18 Chemical Structure

CAS No.: 2668267-41-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

All STAT Isoforms :

All COX Isoforms :

All JAK Isoforms :

In Vitro

STAT3-IN-18 (0.5 μM; 48 h) inhibits the phosphorylation of STAT3 and JAK2, decreases the protein levels of Bcl-2 and COX-2, and increases the protein levels of Bak, Caspase-3, Cleaved PARP1 in MDA-MB-231 cells^[1].
STAT3-IN-18 (0.5μM; 36 h) arrests the cell cycle of MDA-MB-231 cells at S phase, (0.5 μM; 48 h) and induces apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

STAT3-IN-18 (refers to 1.5 mg Pt; every 2 days for 18 days) results inhibition of STAT3 phosphorylation, and inhibits tumor growth in 4T1 xenograft tumor mice model. The median lethal dose (LD50) of DPP is 10.45 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2668267-41-0
Molecular Weight 630.38
Formula C₁₈H₂₄Cl₂N₂O₆Pt
SMILES

[Cl-][Pt+4]([Cl-])([NH3])([NH3])([OH-])[O-]C(COC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cai L, Wang Y, Chen H, Tan Y, Yang T, Zhang S, Guo Z, Wang X. Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11351-11364. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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STAT3-IN-18

All STAT Isoforms

All COX Isoforms

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

STAT3-IN-18 Related Classifications

HY-155808 Related Classifications