2. Neuronal Signaling
  3. Sigma Receptor
  4. Sigma-2 Radioligand 1

Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts.

For research use only. We do not sell to patients.

Sigma-2 Radioligand 1 Chemical Structure

Sigma-2 Radioligand 1 Chemical Structure

CAS No. : 2860554-32-9

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Sigma-2 Radioligand 1 Related Antibodies

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Description

Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1].

IC50 & Target

Ki: 2.57 nM (Sigma-2, σ2)[1]
Molecular Weight

427.51

Formula

C24H30FN3O3
CAS No.
SMILES

FCCN1C(N(C2=C1C=CC=C2)CCCCN3CCC4=C(C3)C=C(C(OC)=C4)OC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sigma-2 Radioligand 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sigma-2 Radioligand 12860554-32-9Sigma ReceptorU87MGSigma-2radioligandInhibitorinhibitorinhibit

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