Synucleozid
Based on 2 publication(s) in Google Scholar
Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease.
For research use only. We do not sell to patients.
- CAS No.: 502139-01-7
- Formula: C22H20N6
- Molecular Weight:368.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Synucleozid
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| CMK | IC50 |
1.31 μM
Compound: K313
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Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34046601] |
| HEL | IC50 |
2.27 μM
Compound: K313
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Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34046601] |
| K562 | IC50 |
1.08 μM
Compound: K313
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34046601] |
| MEG-01 | IC50 |
1.03 μM
Compound: K313
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Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
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[PMID: 34046601] |
Synucleozid (0.25-1 μM; 24 hours) abrogates cytotoxicity induced by α-synuclein preformed fibrils, which act as seeds and recruit endogenous α-synuclein to aggregate[1]. Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner with an IC50 of 500 nM, and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells[1]. Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission with an EC50 value of 2.7 ± 0.4 μM, recovery of 2-AP emissions is observed as a function of unlabeled SNCA IRE RNA (RNA-0) concentration, affording a competitive Kd of 1.5 ± 0.3 μM[1]. Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA’s UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y neuroblastoma cells
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Concentration:0.25 μM, 0.5 μM, 1 μM
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Incubation Time:24 hours
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Result:Decreased LDH release as a dose-dependent manner.
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Cell Line:SH-SY5Y neuroblastoma cells
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Concentration:0.25 μM; 0.5 μM; 1 μM;
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Incubation Time:24 hours
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Result:Decreased α-synuclein expression as a concentration-dependent manner.
Chemical Information
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CAS No. 502139-01-7
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Molecular Weight 368.43
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Formula C22H20N6
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SMILES
N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N
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Synonyms
NSC 377363
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Metab
Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis. [Abstract]2026 Jan 27:S1550-4131(25)00586-8. PMID: 41605214 -
Brain Behav Immun
Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1. [Abstract]2022 Nov:106:247-261. PMID: 36089218
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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