502139-01-7
Chemical Structure
Synucleozid
Synonym(s): NSC 377363
- CAS No.: 502139-01-7
- Formula:C22H20N6
- Molecular Weight:368.43
IUPAC Name: 2-(4-((4-carbamimidoylphenyl)amino)phenyl)-1H-indole-6-carboximidamide
InChIKey: TZRXNWCLKYWDNH-UHFFFAOYSA-N
SMILES: N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N
Biological Activity: Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease[1].
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Synucleozid | Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease. | |||||||||||||||||||||
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Keywords
