Tebanicline (Synonyms: Ebanicline; ABT-594)

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Tebanicline, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

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Tebanicline Chemische Struktur

CAS. Nr. : 198283-73-7

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Other In-stock Forms of Tebanicline:

Tebanicline dihydrochloride Tebanicline tosylate

Other Forms of Tebanicline:

Tebanicline dihydrochloride In-stock
Tebanicline tosylate In-stock
Tebanicline hydrochloride Angebot einholen

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

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Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
IMR-32	EC₅₀	0.02 μM Compound: tebeniciline	Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay	[PMID: 19232492]
IMR-32	EC₅₀	0.13 μM Compound: 4	Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype	[PMID: 9484491]
IMR-32	EC₅₀	0.19 μM Compound: tebeniciline	Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay	[PMID: 19232492]
IMR-32	EC₅₀	0.2 μM Compound: 5 (ABT-594)	Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype	[PMID: 9484491]
Oocyte	EC₅₀	21 μM Compound: 4	Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes. Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.	[PMID: 9484491]
Oocyte	EC₅₀	56 μM Compound: 5 (ABT-594)	Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes. Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.	[PMID: 9484491]

Molekulargewicht

198.65

Formel

C₉H₁₁ClN₂O

CAS. Nr.

198283-73-7

SMILES

ClC(C=C1)=NC=C1OC[C@@H]2NCC2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hayashi T, , et al. Antinociceptive effect of tebanicline for various noxious stimuli-induced behaviours in mice [J]. Neuroscience Letters, 2017, 638: 46-50. [Content Brief]

[2]. Donnelly-Roberts DL, et al. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.J Pharmacol Exp Ther. 1998 May;285(2):777-86. [Content Brief]

[3]. Bannon AW, et al. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285(2):787-94. [Content Brief]

[4]. Decker MW, et al. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice. Eur J Pharmacol. 1998 Apr 3;346(1):23-33. [Content Brief]

[5]. Decker MW, et al. The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594. J Physiol Paris. 1998 Jun-Aug;92(3-4):221-4. [Content Brief]

Tebanicline Related Classifications

Neurological Disease

Molaritätsrechner
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Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tebanicline198283-73-7Ebanicline ABT-594ABT594ABT 594ABT-594nAChRNicotinic acetylcholine receptorsPaw licking miceAntinociceptiveAnalgesic effectInhibitorinhibitorinhibit

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Tebanicline (Synonyms: Ebanicline; ABT-594)

Other Forms of Tebanicline:

Tebanicline Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Tebanicline Related Classifications

Molaritätsrechner

Verdünnungsrechner