Tesirine intermediate-1

Cat. No.: HY-47820 Purity: 99.41%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Tesirine intermediate-1 화학구조

CAS No. : 1430738-05-8

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	견적 받기
10 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

분자량

580.86

화학식

C₂₈H₄₈N₂O₇Si₂

CAS No.

1430738-05-8

Appearance

Solid

Color

White to off-white

SMILES

CC(C)[Si](C(C)C)(C(C)C)OC1=C(C=C(C([N+]([O-])=O)=C1)C(N2[C@@H](CC(C2)=O)CO[Si](C)(C)C(C)(C)C)=O)OC

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (172.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7216 mL	8.6079 mL	17.2159 mL
5 mM	0.3443 mL	1.7216 mL	3.4432 mL
10 mM	0.1722 mL	0.8608 mL	1.7216 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.41%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (230 KB) HNMR (276 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Howard, et al. Process for the preparation of intermediates useful for the synthesis of pyrrolobenzodiazepine dimers. World Intellectual Property Organization, WO2013053872 A1. 2013-04-18.

[2]. Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7216 mL	8.6079 mL	17.2159 mL	43.0396 mL
	5 mM	0.3443 mL	1.7216 mL	3.4432 mL	8.6079 mL
	10 mM	0.1722 mL	0.8608 mL	1.7216 mL	4.3040 mL
	15 mM	0.1148 mL	0.5739 mL	1.1477 mL	2.8693 mL
	20 mM	0.0861 mL	0.4304 mL	0.8608 mL	2.1520 mL
	25 mM	0.0689 mL	0.3443 mL	0.6886 mL	1.7216 mL
	30 mM	0.0574 mL	0.2869 mL	0.5739 mL	1.4347 mL
	40 mM	0.0430 mL	0.2152 mL	0.4304 mL	1.0760 mL
	50 mM	0.0344 mL	0.1722 mL	0.3443 mL	0.8608 mL
	60 mM	0.0287 mL	0.1435 mL	0.2869 mL	0.7173 mL
	80 mM	0.0215 mL	0.1076 mL	0.2152 mL	0.5380 mL
	100 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.4304 mL