trans-1,4-Bis(hydroxymethyl)cyclohexane
Based on 1 Customer Validation
trans-1,4-Bis(hydroxymethyl)cyclohexane is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 99.99%
- CAS No.: 3236-48-4
- Formula: C8H16O2
- Molecular Weight:144.21
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E1101 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3236-48-4
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Appearance Solid
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Molecular Weight 144.21
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Formula C8H16O2
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Color White to off-white
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SMILES
C(O)[C@H]1CC[C@H](CO)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (693.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (240 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.9343 mL | 34.6717 mL | 69.3433 mL | 173.3583 mL |
| 5 mM | 1.3869 mL | 6.9343 mL | 13.8687 mL | 34.6717 mL | |
| 10 mM | 0.6934 mL | 3.4672 mL | 6.9343 mL | 17.3358 mL | |
| 15 mM | 0.4623 mL | 2.3114 mL | 4.6229 mL | 11.5572 mL | |
| 20 mM | 0.3467 mL | 1.7336 mL | 3.4672 mL | 8.6679 mL | |
| 25 mM | 0.2774 mL | 1.3869 mL | 2.7737 mL | 6.9343 mL | |
| 30 mM | 0.2311 mL | 1.1557 mL | 2.3114 mL | 5.7786 mL | |
| 40 mM | 0.1734 mL | 0.8668 mL | 1.7336 mL | 4.3340 mL | |
| 50 mM | 0.1387 mL | 0.6934 mL | 1.3869 mL | 3.4672 mL | |
| 60 mM | 0.1156 mL | 0.5779 mL | 1.1557 mL | 2.8893 mL | |
| 80 mM | 0.0867 mL | 0.4334 mL | 0.8668 mL | 2.1670 mL | |
| 100 mM | 0.0693 mL | 0.3467 mL | 0.6934 mL | 1.7336 mL |
trans-1,4-Bis(hydroxymethyl)cyclohexane Related Classifications
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