trans-Resveratrol-3-O-β-D-Glucuronide
Based on 1 Customer Validation
trans-Resveratrol-3-O-β-D-Glucuronide is an active metabolite of trans-resveratrol. trans-Resveratrol-3-O-β-D-Glucuronide reduces the proliferation of several intestinal cancer cell line. trans-Resveratrol-3-O-β-D-Glucuronide increases pyruvate production in livers.
For research use only. We do not sell to patients.
- Purity: 95.58%
- CAS No.: 387372-17-0
- Formula: C20H20O9
- Molecular Weight:404.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
trans-Resveratrol-3-O-β-D-Glucuronide (48 h) inhibits cell growth with the IC50 valus of 15.8 μM, 16.5 μM and 10.1 μM against CCL-228, Caco-2 and HCT-116 cells, respectively[2].
trans-Resveratrol-3-O-β-D-Glucuronide (30 μM, 48 h) induces S phase arrest in CCL-228, Caco-2 and HCT-116 cells[2].
trans-Resveratrol-3-O-β-D-Glucuronide (200 μM, 10 mins) increases pyruvate production in livers isolated from rats in a model of arthritis induced by complete Freund's adjuvant[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CCL-228, Caco-2 and HCT-116
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Concentration:0 to 100 μM
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Incubation Time:48 h
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Result:Inhibited cell growth with the IC50 valus of 15.8 μM, 16.5 μM and 10.1 μM against CCL-228, Caco-2 and HCT-116 cells, respectively.
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Cell Line:CCL-228, Caco-2 and HCT-116
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Concentration:30 μM
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Incubation Time:48 h
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Result:Induced S phase arrest.
Chemical Information
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CAS No. 387372-17-0
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Appearance Solid
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Molecular Weight 404.37
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Formula C20H20O9
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Color Off-white to light yellow
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SMILES
OC([C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC(/C=C/C3=CC=C(C=C3)O)=CC(O)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (123.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Rousova J, et al. Determination of trans-resveratrol and its metabolites in rat serum using liquid chromatography with high-resolution time of flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1039:35-43. [Content Brief]
[2]. Polycarpou E, et al. Resveratrol 3-O-D-glucuronide and resveratrol 4'-O-D-glucuronide inhibit colon cancer cell growth: evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. Mol Nutr Food Res. 2013;57(10):1708-1717. [Content Brief]
[3]. Simões MS, et al. Resveratrol biotransformation and actions on the liver metabolism of healthy and arthritic rats. Life Sci. 2022;310:120991. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4730 mL | 12.3649 mL | 24.7298 mL | 61.8246 mL |
| 5 mM | 0.4946 mL | 2.4730 mL | 4.9460 mL | 12.3649 mL | |
| 10 mM | 0.2473 mL | 1.2365 mL | 2.4730 mL | 6.1825 mL | |
| 15 mM | 0.1649 mL | 0.8243 mL | 1.6487 mL | 4.1216 mL | |
| 20 mM | 0.1236 mL | 0.6182 mL | 1.2365 mL | 3.0912 mL | |
| 25 mM | 0.0989 mL | 0.4946 mL | 0.9892 mL | 2.4730 mL | |
| 30 mM | 0.0824 mL | 0.4122 mL | 0.8243 mL | 2.0608 mL | |
| 40 mM | 0.0618 mL | 0.3091 mL | 0.6182 mL | 1.5456 mL | |
| 50 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2365 mL | |
| 60 mM | 0.0412 mL | 0.2061 mL | 0.4122 mL | 1.0304 mL | |
| 80 mM | 0.0309 mL | 0.1546 mL | 0.3091 mL | 0.7728 mL | |
| 100 mM | 0.0247 mL | 0.1236 mL | 0.2473 mL | 0.6182 mL |
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