Tubulin inhibitor 23
Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC50 of 4.8 µM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia.
For research use only. We do not sell to patients.
- CAS No.: 170488-57-0
- Formula: C26H23NO6S
- Molecular Weight:477.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 4.8 µM (Tubulin)[1]
In Vitro
Tubulin inhibitor 23 (compound 29e) (0-100 µM) inhibits tubulin polymerisation (IC50=4.8 µM) and anti-angiogenesis (IC50=3.4 µM) in Zebrafish[1].
Tubulin inhibitor 23 (0-200 nM; 48 h) induces cell apoptosis in a concentration-dependent manner[1].
Tubulin inhibitor 23 (0-20 µM; 0-29 min) binds to the colchicine site of tubulin and inhibit the microtubule polymerisation[1].
Tubulin inhibitor 23 (0.1, 1, 10 µM; 1 h) shows anti-angiogenesis activity with low toxicity (IC50=58.6 µM) in Human umbilical vein endothelial cells (HUVECs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11, HL60, K562, THP-1,CCRF-CEM, Jurkat, HuT 78 cells
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Concentration:
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Incubation Time:72 h
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Result:Showed potent growth inhibitory activity with IC50s of 0.25, 0.18, 0.09, 0.37, 0.84, 1.22, 0.26 µM for MV4-11, HL60, K562, THP-1,CCRF-CEM, Jurkat, HuT 78 cells, respectively.
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Cell Line:K562 cells
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Concentration:0, 50, 100, 200 nM
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Incubation Time:48 h
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Result:The percentage of apoptotic cell significantly increased from 5.95% to 45.81%.
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Cell Line:K562 cells
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Concentration:0, 50, 100, 200 nM
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Incubation Time:48 h
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Result:Increased the expression of cleaved caspase-3 and PARP.
In Vivo
Tubulin inhibitor 23 (2, 6 µM; add into embryo water) suppresses the proliferation and metastasis of K562 cells in zebrafish xenografts in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3hpf zebrafish embryos[1]
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Dosage:2.0, 6.0 µM
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Administration:Add into embryo water
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Result:Decreased the number and length of ISVs (intersegmental vessels) in a dose-dependent inhibition pattern.
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Animal Model:Transgenic zebrafish (fil1:EGFP) (K562 cell xenograft)[1]
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Dosage:2, 6 µM
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Administration:Add into embryo water
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Result:Reduced intensities and decreased tumour area.
Chemical Information
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CAS No. 170488-57-0
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Molecular Weight 477.53
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Formula C26H23NO6S
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SMILES
O=C(C1=CC(OC)=C(OC)C(OC)=C1)/C=C/C2=CN(S(=O)(C3=CC=CC=C3)=O)C4=C2C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin inhibitor 23 Related Classifications
HY-144818 Related Classifications
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