Tubulin inhibitor 23 

Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC₅₀ of 4.8 µM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia^[1].

IC₅₀: 4.8 µM (Tubulin)^[1]

Tubulin inhibitor 23 (compound 29e) (0-100 µM) inhibits tubulin polymerisation (IC₅₀=4.8 µM) and anti-angiogenesis (IC₅₀=3.4 µM) in Zebrafish^[1].
Tubulin inhibitor 23 (0-200 nM; 48 h) induces cell apoptosis in a concentration-dependent manner^[1].
Tubulin inhibitor 23 (0-20 µM; 0-29 min) binds to the colchicine site of tubulin and inhibit the microtubule polymerisation^[1].
Tubulin inhibitor 23 (0.1, 1, 10 µM; 1 h) shows anti-angiogenesis activity with low toxicity (IC₅₀=58.6 µM) in Human umbilical vein endothelial cells (HUVECs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 23 (2, 6 µM; add into embryo water) shows antiangiogenic activity in a dose-dependent manner^[1].
Tubulin inhibitor 23 (2, 6 µM; add into embryo water) suppresses the proliferation and metastasis of K562 cells in zebrafish xenografts in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

477.53

C₂₆H₂₃NO₆S

170488-57-0

O=C(C1=CC(OC)=C(OC)C(OC)=C1)/C=C/C2=CN(S(=O)(C3=CC=CC=C3)=O)C4=C2C=CC=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yao Y,wt al. Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):652-665.  [Content Brief]