Tubulin inhibitor 34
Tubulin inhibitor 34 (compound b5) is a potent anticancer agent. Tubulin inhibitor 34 can inhibit tubulin polymerization and induce G2/M arrest and apoptosis. Tubulin inhibitor 34 exhibits significant antivascular and antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 3048497-78-2
- Formula: C21H22N4O3S
- Molecular Weight:410.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.96 μM
Compound: B5
|
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
|
[PMID: 37172475] |
| HEK293 | IC50 |
>100 μM
Compound: B5
|
Antiproliferative activity against human HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
|
[PMID: 37172475] |
| HeLa | IC50 |
0.046 μM
Compound: B5
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Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
|
[PMID: 37172475] |
| HT-29 | IC50 |
0.57 μM
Compound: B5
|
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
|
[PMID: 37172475] |
| MDA-MB-231 | IC50 |
1.89 μM
Compound: B5
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Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
|
[PMID: 37172475] |
Chemical Information
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CAS No. 3048497-78-2
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Molecular Weight 410.49
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Formula C21H22N4O3S
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SMILES
COC1=C(OC)C(OC)=CC(CC2=NN=C3N2N=C(C4=CC=C(C)C=C4)CS3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ji T, et, al. Discovery of novel 6-p-tolyl-3-(3,4,5-trimethoxybenzyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivative as a potent tubulin inhibitor with promising in vivo antitumor activity. Eur J Med Chem. 2023 Aug 5;256:115437. [Content Brief]
[2]. Lu L, et, al. Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists. Eur J Med Chem. 2023 Aug 5;256:115424. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin inhibitor 34 Related Classifications
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