Tubulin inhibitor 41
Tubulin inhibitor 41 (Compd D19), a promising anti-GBM (glioblastoma) lead compound and tublin inhibitor with BBB permeability, induces G2/M phase arrest, resulted in cell apoptosis and inhibits the migration of U87 cells.
For research use only. We do not sell to patients.
- CAS No.: 2770273-12-4
- Formula: C20H15N3O
- Molecular Weight:313.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.88 μM
Compound: D19
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 38350361] |
| Huh-7 | IC50 |
1.19 μM
Compound: D19
|
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 38350361] |
| HUVEC | IC50 |
>10 μM
Compound: D19
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Cytotoxicity against HUVEC cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 38350361] |
| U-87MG ATCC | IC50 |
0.9 μM
Compound: D19
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Antiproliferative activity against human U87 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human U87 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
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[PMID: 38350361] |
In Vitro
Tubulin inhibitor 41 (Compd D19) displays positive antiproliferative activity against U87 cancer cell line (IC50 = 0.90 ± 0.03 μM). Tubulin inhibitor 41 (Compd D19) could degrade the intracellular tubulin skeletons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2770273-12-4
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Molecular Weight 313.35
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Formula C20H15N3O
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SMILES
N#CC(C1C2=CC=CC=C2)=C(N)OC3=C1C=CC4=C3N=C(C)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin inhibitor 41 Related Classifications
HY-161256 Related Classifications
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