Tubulin inhibitor 41
Tubulin inhibitor 41 (Compd D19), a promising anti-GBM (glioblastoma) lead compound and tublin inhibitor with BBB permeability, induces G2/M phase arrest, resulted in cell apoptosis and inhibits the migration of U87 cells.
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- CAS 番号: 2770273-12-4
- 分子式: C20H15N3O
- 分子量:313.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.88 μM
Compound: D19
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 38350361] |
| Huh-7 | IC50 |
1.19 μM
Compound: D19
|
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 38350361] |
| HUVEC | IC50 |
>10 μM
Compound: D19
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Cytotoxicity against HUVEC cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
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[PMID: 38350361] |
| U-87MG ATCC | IC50 |
0.9 μM
Compound: D19
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Antiproliferative activity against human U87 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human U87 cells assessed as inhibition of cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 38350361] |
Tubulin inhibitor 41 (Compd D19) displays positive antiproliferative activity against U87 cancer cell line (IC50 = 0.90 ± 0.03 μM). Tubulin inhibitor 41 (Compd D19) could degrade the intracellular tubulin skeletons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2770273-12-4
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分子量 313.35
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分子式 C20H15N3O
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SMILES
N#CC(C1C2=CC=CC=C2)=C(N)OC3=C1C=CC4=C3N=C(C)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tubulin inhibitor 41 関連分類
HY-161256 関連分類
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