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Cat. No.: HY-160853

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Tubulin inhibitor 42

Tubulin inhibitor 42 (Compound 14b) dose-dependently inhibited the activity of β-microtubulin (IC₅₀ = 3.5 µM).Tubulin inhibitor 42 interferes with microtubule dynamic homeostasis, resulting in the arrest of the cancer cell cycle in the G2/M phase and inducing apoptosis. Tubulin inhibitor 42 significantly inhibits the angiogenic process in vitro and in vivo, preventing vascularization and tumor growth.

For research use only. We do not sell to patients.

CAS No.: 2135713-96-9
Formula: C₂₀H₂₃NO₇
Molecular Weight:389.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tubulin inhibitor 42 Chemical Structure

CAS No.: 2135713-96-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.014 μM Compound: 14b	Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay	[PMID: 29306206]
A2780	IC₅₀	14 nM Compound: 1	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32339854]
HeLa	IC₅₀	0.021 μM Compound: 14b	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29306206]
HeLa	IC₅₀	21 nM Compound: 1	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32339854]
HeLa	IC₅₀	5.9 nM Compound: 1, Racemic	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35405397]
Huh-7	IC₅₀	21 nM Compound: 1	Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32339854]
MCF7	IC₅₀	14.8 nM Compound: 1, Racemic	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35405397]
MDA-MB-231	IC₅₀	0.016 μM Compound: 14b	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29306206]
MDA-MB-231	IC₅₀	11.9 nM Compound: 1, Racemic	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35405397]
MDA-MB-231	IC₅₀	16 nM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32339854]
SK-OV-3	IC₅₀	0.021 μM Compound: 14b	Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 29306206]
SK-OV-3	IC₅₀	21.3 nM Compound: 1, Racemic	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35405397]

Chemical Information

CAS No. 2135713-96-9
Molecular Weight 389.40
Formula C₂₀H₂₃NO₇
SMILES

OC[C@H]1[C@H](C2=CC(O)=C(C=C2)OC)N(C3=CC(OC)=C(C(OC)=C3)OC)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou P, et al.Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents. Eur J Med Chem. 2018 Jan 20;144:817-842. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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