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Cat. No.: HY-137866

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Tubulin inhibitor 9

Tubulin inhibitor 9 (compound 7) is a tubulin (Microtubule/Tubulin)Inhibitors with anticancer activity (MDA-MB 231, IC₅₀=0.9 nM).

For research use only. We do not sell to patients.

CAS No.: 1151995-69-5
Formula: C₁₉H₁₉NO₅
Molecular Weight:341.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Tubulin inhibitor 9 Chemical Structure

CAS No.: 1151995-69-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tubulin inhibitor 9 (compound 7) is a tubulin (Microtubule/Tubulin)Inhibitors with anticancer activity (MDA-MB 231, IC₅₀=0.9 nM)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	0.0007 μM Compound: 7	Antiproliferative activity against estrogen-dependent breast cancer MCF7 cell line by MTS assay Antiproliferative activity against estrogen-dependent breast cancer MCF7 cell line by MTS assay	[PMID: 16213720]
MDA-MB-231	IC₅₀	0.0009 μM Compound: 7	Antiproliferative activity against estrogen-independent breast cancer MDA-MB-231 cell line by MTS assay Antiproliferative activity against estrogen-independent breast cancer MDA-MB-231 cell line by MTS assay	[PMID: 16213720]
MDA-MB-231	IC₅₀	0.88 nM Compound: 1	Cytotoxicity against hormone-independent human MDA-MB-231 cells assessed as growth inhibition by MTS assay Cytotoxicity against hormone-independent human MDA-MB-231 cells assessed as growth inhibition by MTS assay	[PMID: 23790539]
PC-3	IC₅₀	0.0082 μM Compound: 7	Antiproliferative activity against androgen-independent prostate cancer PC3 cell line by MTS assay Antiproliferative activity against androgen-independent prostate cancer PC3 cell line by MTS assay	[PMID: 16213720]
PC-3	IC₅₀	8.2 nM Compound: 1	Cytotoxicity against hormone-independent human PC3 cells assessed as growth inhibition by MTS assay Cytotoxicity against hormone-independent human PC3 cells assessed as growth inhibition by MTS assay	[PMID: 23790539]

Chemical Information

CAS No. 1151995-69-5
Molecular Weight 341.36
Formula C₁₉H₁₉NO₅
SMILES

O=C1NC2=C(C=CC(OC)=C2)/C1=C/C3=CC(OC)=C(OC)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Theoretical Studies on QSAR and Mechanism of 2-Indolinone Derivatives as Tubulin Inhibitors

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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