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Cat. No.: HY-146863

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Tubulin polymerization-IN-10

Tubulin polymerization-IN-10 is a potent tubulin polymerization inhibitor with an IC₅₀ of 4.25±0.75 μM. Tubulin polymerization-IN-10 has anti-tumor effects.

For research use only. We do not sell to patients.

CAS No.: 2238784-19-3
Formula: C₁₈H₂₁NO₆S
Molecular Weight:379.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Tubulin polymerization-IN-10 Chemical Structure

CAS No.: 2238784-19-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tubulin polymerization-IN-10 is a potent tubulin polymerization inhibitor with an IC₅₀ of 4.25±0.75 μM. Tubulin polymerization-IN-10 has anti-tumor effects^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.606 μM Compound: 12m	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30176537]
A549	IC₅₀	606 nM Compound: 16a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]
HCT-8	IC₅₀	0.332 μM Compound: 4	Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
HepG2	IC₅₀	0.217 μM Compound: 12m	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30176537]
HepG2	IC₅₀	0.217 μM Compound: 4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
HepG2	IC₅₀	217 nM Compound: 16a	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]
HUVEC	IC₅₀	4.25 μM Compound: 16a	Antitubulin activity against HUVEC assessed as morphological changes of tube incubated for 6 hrs by inverted microscope Antitubulin activity against HUVEC assessed as morphological changes of tube incubated for 6 hrs by inverted microscope	[PMID: 35305462]
K562	IC₅₀	0.128 μM Compound: 12m	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30176537]
K562	IC₅₀	0.128 μM Compound: 4	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
K562	IC₅₀	128 nM Compound: 16a	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]

Chemical Information

CAS No. 2238784-19-3
Molecular Weight 379.43
Formula C₁₈H₂₁NO₆S
SMILES

NC1=CC(/C=C/S(=O)(C2=CC(OC)=C(OC)C(OC)=C2)=O)=CC=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huajian Zhu, et al. Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. Eur J Med Chem . 2020 Dec 1;207:112716. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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