Tubulin polymerization-IN-10

製品番号: HY-146863: Data Sheet 取扱説明書
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Tubulin polymerization-IN-10 is a potent tubulin polymerization inhibitor with an IC₅₀ of 4.25±0.75 μM. Tubulin polymerization-IN-10 has anti-tumor effects.

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Tubulin polymerization-IN-10 構造式

CAS 番号 : 2238784-19-3

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製品説明

Tubulin polymerization-IN-10 is a potent tubulin polymerization inhibitor with an IC₅₀ of 4.25±0.75 μM. Tubulin polymerization-IN-10 has anti-tumor effects^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.606 μM Compound: 12m	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30176537]
A549	IC₅₀	606 nM Compound: 16a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]
HCT-8	IC₅₀	0.332 μM Compound: 4	Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
HUVEC	IC₅₀	4.25 μM Compound: 16a	Antitubulin activity against HUVEC assessed as morphological changes of tube incubated for 6 hrs by inverted microscope Antitubulin activity against HUVEC assessed as morphological changes of tube incubated for 6 hrs by inverted microscope	[PMID: 35305462]
HepG2	IC₅₀	0.217 μM Compound: 12m	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30176537]
HepG2	IC₅₀	0.217 μM Compound: 4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
HepG2	IC₅₀	217 nM Compound: 16a	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]
K562	IC₅₀	0.128 μM Compound: 12m	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30176537]
K562	IC₅₀	0.128 μM Compound: 4	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
K562	IC₅₀	128 nM Compound: 16a	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]

分子量

379.43

分子式

C₁₈H₂₁NO₆S

CAS 番号

2238784-19-3

SMILES

NC1=CC(/C=C/S(=O)(C2=CC(OC)=C(OC)C(OC)=C2)=O)=CC=C1OC

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Huajian Zhu, et al. Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. Eur J Med Chem . 2020 Dec 1;207:112716. [Content Brief]