Cat. No.: HY-146378

Tubulin polymerization-IN-20

Tubulin polymerization-IN-20 (compound 11) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-20 has the potential for the research of breast cancers and chemoresistant colon cancers.

For research use only. We do not sell to patients.

CAS No.: 2410619-45-1
Formula: C₂₅H₂₄FNO₅
Molecular Weight:437.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tubulin polymerization-IN-20 Chemical Structure

CAS No.: 2410619-45-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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References
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.0314 μM Compound: 11; D-788819	Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition	[PMID: 31954879]
A498	GI₅₀	0.027 μM Compound: 11; D-788819	Antiproliferative activity against human A498 cells assessed as cell growth inhibition Antiproliferative activity against human A498 cells assessed as cell growth inhibition	[PMID: 31954879]
A549	GI₅₀	0.0368 μM Compound: 11; D-788819	Antiproliferative activity against human A549 cells assessed as cell growth inhibition Antiproliferative activity against human A549 cells assessed as cell growth inhibition	[PMID: 31954879]
ACHN	GI₅₀	0.044 μM Compound: 11; D-788819	Antiproliferative activity against human ACHN cells assessed as cell growth inhibition Antiproliferative activity against human ACHN cells assessed as cell growth inhibition	[PMID: 31954879]
BT-549	GI₅₀	0.0266 μM Compound: 11; D-788819	Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition	[PMID: 31954879]
CAKI-1	GI₅₀	0.0332 μM Compound: 11; D-788819	Antiproliferative activity against human CAK-1 cells assessed as cell growth inhibition Antiproliferative activity against human CAK-1 cells assessed as cell growth inhibition	[PMID: 31954879]
CCRF-CEM	GI₅₀	0.0361 μM Compound: 11; D-788819	Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition	[PMID: 31954879]
COLO 205	GI₅₀	0.0194 μM Compound: 11; D-788819	Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition	[PMID: 31954879]
DU-145	GI₅₀	0.0354 μM Compound: 11; D-788819	Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition	[PMID: 31954879]
EKVX	GI₅₀	0.0776 μM Compound: 11; D-788819	Antiproliferative activity against human EKVX cells assessed as cell growth inhibition Antiproliferative activity against human EKVX cells assessed as cell growth inhibition	[PMID: 31954879]
HCC 2998	GI₅₀	0.0394 μM Compound: 11; D-788819	Antiproliferative activity against human HCC-2998 cells assessed as cell growth inhibition Antiproliferative activity against human HCC-2998 cells assessed as cell growth inhibition	[PMID: 31954879]
HCT-116	GI₅₀	0.0324 μM Compound: 11; D-788819	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition	[PMID: 31954879]
HCT-15	GI₅₀	0.0336 μM Compound: 11; D-788819	Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition	[PMID: 31954879]
HL-60	GI₅₀	0.0223 μM Compound: 11; D-788819	Antiproliferative activity against human HL60 cells assessed as cell growth inhibition Antiproliferative activity against human HL60 cells assessed as cell growth inhibition	[PMID: 31954879]
HOP-62	GI₅₀	0.0379 μM Compound: 11; D-788819	Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition	[PMID: 31954879]
HOP-92	GI₅₀	2.84 μM Compound: 11; D-788819	Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition	[PMID: 31954879]
Hs-578T	GI₅₀	0.0434 μM Compound: 11; D-788819	Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition	[PMID: 31954879]
HT-29	GI₅₀	0.026 μM Compound: 11; D-788819	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition	[PMID: 31954879]
HT-29	IC₅₀	0.009 μM Compound: 11; D-788819	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 31954879]
IGROV-1	GI₅₀	0.0428 μM Compound: 11; D-788819	Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition	[PMID: 31954879]
K562	GI₅₀	0.0321 μM Compound: 11; D-788819	Antiproliferative activity against human K-562 cells assessed as cell growth inhibition Antiproliferative activity against human K-562 cells assessed as cell growth inhibition	[PMID: 31954879]
KM12	GI₅₀	0.0331 μM Compound: 11; D-788819	Antiproliferative activity against human KM12 cells assessed as cell growth inhibition Antiproliferative activity against human KM12 cells assessed as cell growth inhibition	[PMID: 31954879]
LOX IMVI	GI₅₀	0.0296 μM Compound: 11; D-788819	Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition	[PMID: 31954879]
M14	GI₅₀	0.0226 μM Compound: 11; D-788819	Antiproliferative activity against human M14 cells assessed as cell growth inhibition Antiproliferative activity against human M14 cells assessed as cell growth inhibition	[PMID: 31954879]
Malme-3M	GI₅₀	>100 μM Compound: 11; D-788819	Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition	[PMID: 31954879]
MCF7	GI₅₀	0.0296 μM Compound: 11; D-788819	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition	[PMID: 31954879]
MCF7	IC₅₀	0.017 μM Compound: 11; D-788819	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 31954879]
MDA-MB-231	GI₅₀	0.0452 μM Compound: 11; D-788819	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition	[PMID: 31954879]
MDA-MB-435	GI₅₀	0.0187 μM Compound: 11; D-788819	Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition	[PMID: 31954879]
MDA-MB-468	GI₅₀	0.0287 μM Compound: 11; D-788819	Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition	[PMID: 31954879]
MOLT-4	GI₅₀	0.0381 μM Compound: 11; D-788819	Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition	[PMID: 31954879]
NCI/ADR-RES	GI₅₀	0.0394 μM Compound: 11; D-788819	Antiproliferative activity against human NCI/ADR-RES cells assessed as cell growth inhibition Antiproliferative activity against human NCI/ADR-RES cells assessed as cell growth inhibition	[PMID: 31954879]
NCI-H226	GI₅₀	0.035 μM Compound: 11; D-788819	Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition	[PMID: 31954879]
NCI-H23	GI₅₀	0.0489 μM Compound: 11; D-788819	Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition	[PMID: 31954879]
NCI-H460	GI₅₀	0.0344 μM Compound: 11; D-788819	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition	[PMID: 31954879]
NCI-H522	GI₅₀	0.0186 μM Compound: 11; D-788819	Antiproliferative activity against human NCI-H552 cells assessed as cell growth inhibition Antiproliferative activity against human NCI-H552 cells assessed as cell growth inhibition	[PMID: 31954879]
OVCAR-3	GI₅₀	0.028 μM Compound: 11; D-788819	Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition	[PMID: 31954879]
OVCAR-4	GI₅₀	0.0871 μM Compound: 11; D-788819	Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition	[PMID: 31954879]
OVCAR-5	GI₅₀	0.0517 μM Compound: 11; D-788819	Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition	[PMID: 31954879]
OVCAR-8	GI₅₀	0.0344 μM Compound: 11; D-788819	Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition	[PMID: 31954879]
PC-3	GI₅₀	0.0403 μM Compound: 11; D-788819	Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition	[PMID: 31954879]
RPMI-8226	GI₅₀	0.0413 μM Compound: 11; D-788819	Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition	[PMID: 31954879]
SF-268	GI₅₀	0.0443 μM Compound: 11; D-788819	Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition	[PMID: 31954879]
SF-295	GI₅₀	0.029 μM Compound: 11; D-788819	Antiproliferative activity against human SF295 cells assessed as cell growth inhibition Antiproliferative activity against human SF295 cells assessed as cell growth inhibition	[PMID: 31954879]
SF-539	GI₅₀	0.0234 μM Compound: 11; D-788819	Antiproliferative activity against human SF539 cells assessed as cell growth inhibition Antiproliferative activity against human SF539 cells assessed as cell growth inhibition	[PMID: 31954879]
SK-MEL-2	GI₅₀	0.0354 μM Compound: 11; D-788819	Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition	[PMID: 31954879]
SK-MEL-28	GI₅₀	1.37 μM Compound: 11; D-788819	Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition	[PMID: 31954879]
SK-MEL-5	GI₅₀	0.0271 μM Compound: 11; D-788819	Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition	[PMID: 31954879]
SK-OV-3	GI₅₀	0.0348 μM Compound: 11; D-788819	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition	[PMID: 31954879]
SN12C	GI₅₀	0.0561 μM Compound: 11; D-788819	Antiproliferative activity against human SN12C cells assessed as cell growth inhibition Antiproliferative activity against human SN12C cells assessed as cell growth inhibition	[PMID: 31954879]
SNB-19	GI₅₀	0.0499 μM Compound: 11; D-788819	Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition	[PMID: 31954879]
SNB-75	GI₅₀	0.0314 μM Compound: 11; D-788819	Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition	[PMID: 31954879]
SR	GI₅₀	0.0373 μM Compound: 11; D-788819	Antiproliferative activity against human SR cells assessed as cell growth inhibition Antiproliferative activity against human SR cells assessed as cell growth inhibition	[PMID: 31954879]
SW-620	GI₅₀	0.0419 μM Compound: 11; D-788819	Antiproliferative activity against human SW-620 cells assessed as cell growth inhibition Antiproliferative activity against human SW-620 cells assessed as cell growth inhibition	[PMID: 31954879]
T47D	GI₅₀	>100 μM Compound: 11; D-788819	Antiproliferative activity against human T47D cells assessed as cell growth inhibition Antiproliferative activity against human T47D cells assessed as cell growth inhibition	[PMID: 31954879]
TK-10	GI₅₀	1.68 μM Compound: 11; D-788819	Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition	[PMID: 31954879]
U-251	GI₅₀	0.0359 μM Compound: 11; D-788819	Antiproliferative activity against human U251 cells assessed as cell growth inhibition Antiproliferative activity against human U251 cells assessed as cell growth inhibition	[PMID: 31954879]
UACC-62	GI₅₀	0.0543 μM Compound: 11; D-788819	Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition	[PMID: 31954879]
UO-31	GI₅₀	0.0771 μM Compound: 11; D-788819	Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition	[PMID: 31954879]

Chemical Information

CAS No. 2410619-45-1
Molecular Weight 437.46
Formula C₂₅H₂₄FNO₅
SMILES

COC1=CC(N2C([C@H]([C@@H]2C3=CC(F)=C(C=C3)OC)C4=CC=CC=C4)=O)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Malebari AM, et al. β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells. Eur J Med Chem. 2020;189:112050. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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