Cat. No.: HY-155043

Tubulin polymerization-IN-42

Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, is an inhibitor of tubulin polymerization with anti-cancer activity.

For research use only. We do not sell to patients.

CAS No.: 2640220-51-3
Formula: C₂₂H₂₁NO₅
Molecular Weight:379.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Tubulin polymerization-IN-42 Chemical Structure

CAS No.: 2640220-51-3

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, is an inhibitor of tubulin polymerization with anti-cancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	316 nM Compound: 10j	Growth inhibition of human 786-0 cells by MTT assay Growth inhibition of human 786-0 cells by MTT assay	[PMID: 37236376]
A498	GI₅₀	17 nM Compound: 10j	Growth inhibition of human A498 cells by MTT assay Growth inhibition of human A498 cells by MTT assay	[PMID: 37236376]
A549	GI₅₀	100 nM Compound: 10j	Growth inhibition of human A549 cells by MTT assay Growth inhibition of human A549 cells by MTT assay	[PMID: 37236376]
ACHN	GI₅₀	537 nM Compound: 10j	Growth inhibition of human ACHN cells by MTT assay Growth inhibition of human ACHN cells by MTT assay	[PMID: 37236376]
BT-549	GI₅₀	62 nM Compound: 10j	Growth inhibition of human BT-549 cells by MTT assay Growth inhibition of human BT-549 cells by MTT assay	[PMID: 37236376]
CAKI-1	GI₅₀	52 nM Compound: 10j	Growth inhibition of human CAKI-1 cells by MTT assay Growth inhibition of human CAKI-1 cells by MTT assay	[PMID: 37236376]
CCRF-CEM	GI₅₀	59 nM Compound: 10j	Growth inhibition of human CCRF-CEM cells by MTT assay Growth inhibition of human CCRF-CEM cells by MTT assay	[PMID: 37236376]
COLO 205	GI₅₀	65 nM Compound: 10j	Growth inhibition of human COLO 205 cells by MTT assay Growth inhibition of human COLO 205 cells by MTT assay	[PMID: 37236376]
DU-145	GI₅₀	209 nM Compound: 10j	Growth inhibition of human DU-145 cells by MTT assay Growth inhibition of human DU-145 cells by MTT assay	[PMID: 37236376]
EKVX	GI₅₀	151 nM Compound: 10j	Growth inhibition of human EKVX cells by MTT assay Growth inhibition of human EKVX cells by MTT assay	[PMID: 37236376]
HCC 2998	GI₅₀	219 nM Compound: 10j	Growth inhibition of human HCC 2998 cells by MTT assay Growth inhibition of human HCC 2998 cells by MTT assay	[PMID: 37236376]
HCT-116	GI₅₀	40 nM Compound: 10j	Growth inhibition of human HCT-116 cells by MTT assay Growth inhibition of human HCT-116 cells by MTT assay	[PMID: 37236376]
HCT-15	GI₅₀	43 nM Compound: 10j	Growth inhibition of human HCT-15 cells by MTT assay Growth inhibition of human HCT-15 cells by MTT assay	[PMID: 37236376]
HL-60	GI₅₀	43 nM Compound: 10j	Growth inhibition of human HL-60 cells by MTT assay Growth inhibition of human HL-60 cells by MTT assay	[PMID: 37236376]
HOP-62	GI₅₀	123 nM Compound: 10j	Growth inhibition of human HOP-62 cells by MTT assay Growth inhibition of human HOP-62 cells by MTT assay	[PMID: 37236376]
HOP-92	GI₅₀	251 nM Compound: 10j	Growth inhibition of human HOP-92 cells by MTT assay Growth inhibition of human HOP-92 cells by MTT assay	[PMID: 37236376]
Hs-578T	GI₅₀	158 nM Compound: 10j	Growth inhibition of human Hs-578T cells by MTT assay Growth inhibition of human Hs-578T cells by MTT assay	[PMID: 37236376]
HT-29	GI₅₀	38 nM Compound: 10j	Growth inhibition of human HT-29 cells by MTT assay Growth inhibition of human HT-29 cells by MTT assay	[PMID: 37236376]
IGROV-1	IC₅₀	76 nM Compound: 10j	Growth inhibition of human IGROV-1 cells by MTT assay Growth inhibition of human IGROV-1 cells by MTT assay	[PMID: 37236376]
K562	GI₅₀	37 nM Compound: 10j	Growth inhibition of human K562 cells by MTT assay Growth inhibition of human K562 cells by MTT assay	[PMID: 37236376]
KM12	GI₅₀	65 nM Compound: 10j	Growth inhibition of human KM12 cells by MTT assay Growth inhibition of human KM12 cells by MTT assay	[PMID: 37236376]
LOX IMVI	GI₅₀	66 nM Compound: 10j	Growth inhibition of human LOX IMVI cells by MTT assay Growth inhibition of human LOX IMVI cells by MTT assay	[PMID: 37236376]
M14	GI₅₀	37 nM Compound: 10j	Growth inhibition of human M14 cells by MTT assay Growth inhibition of human M14 cells by MTT assay	[PMID: 37236376]
Malme-3M	GI₅₀	195 nM Compound: 10j	Growth inhibition of human Malme-3M cells by MTT assay Growth inhibition of human Malme-3M cells by MTT assay	[PMID: 37236376]
MCF7	GI₅₀	28 nM Compound: 10j	Growth inhibition of human MCF7 cells by MTT assay Growth inhibition of human MCF7 cells by MTT assay	[PMID: 37236376]
MDA-MB-231	GI₅₀	339 nM Compound: 10j	Growth inhibition of human MDA-MB-231 cells by MTT assay Growth inhibition of human MDA-MB-231 cells by MTT assay	[PMID: 37236376]
MDA-MB-435	GI₅₀	25 nM Compound: 10j	Growth inhibition of human MDA-MB-435 cells by MTT assay Growth inhibition of human MDA-MB-435 cells by MTT assay	[PMID: 37236376]
MDA-MB-468	GI₅₀	32 nM Compound: 10j	Growth inhibition of human MDA-MB-468 cells by MTT assay Growth inhibition of human MDA-MB-468 cells by MTT assay	[PMID: 37236376]
MOLT-4	GI₅₀	55 nM Compound: 10j	Growth inhibition of human MOLT-4 cells by MTT assay Growth inhibition of human MOLT-4 cells by MTT assay	[PMID: 37236376]
NCI/ADR-RES	GI₅₀	47 nM Compound: 10j	Growth inhibition of human NCI/ADR-RES cells by MTT assay Growth inhibition of human NCI/ADR-RES cells by MTT assay	[PMID: 37236376]
NCI-H226	GI₅₀	692 nM Compound: 10j	Growth inhibition of human NCI-H226 cells by MTT assay Growth inhibition of human NCI-H226 cells by MTT assay	[PMID: 37236376]
NCI-H23	GI₅₀	234 nM Compound: 10j	Growth inhibition of human NCI-H23 cells by MTT assay Growth inhibition of human NCI-H23 cells by MTT assay	[PMID: 37236376]
NCI-H322M	GI₅₀	407 nM Compound: 10j	Growth inhibition of human NCI-H322M cells by MTT assay Growth inhibition of human NCI-H322M cells by MTT assay	[PMID: 37236376]
NCI-H460	GI₅₀	54 nM Compound: 10j	Growth inhibition of human NCI-H460 cells by MTT assay Growth inhibition of human NCI-H460 cells by MTT assay	[PMID: 37236376]
NCI-H522	GI₅₀	49 nM Compound: 10j	Growth inhibition of human NCI-H522 cells by MTT assay Growth inhibition of human NCI-H522 cells by MTT assay	[PMID: 37236376]
OVCAR-3	GI₅₀	36 nM Compound: 10j	Growth inhibition of human OVCAR-3 cells by MTT assay Growth inhibition of human OVCAR-3 cells by MTT assay	[PMID: 37236376]
OVCAR-4	GI₅₀	1259 nM Compound: 10j	Growth inhibition of human OVCAR-4 cells by MTT assay Growth inhibition of human OVCAR-4 cells by MTT assay	[PMID: 37236376]
OVCAR-5	GI₅₀	479 nM Compound: 10j	Growth inhibition of human OVCAR-5 cells by MTT assay Growth inhibition of human OVCAR-5 cells by MTT assay	[PMID: 37236376]
OVCAR-8	GI₅₀	339 nM Compound: 10j	Growth inhibition of human OVCAR-8 cells by MTT assay Growth inhibition of human OVCAR-8 cells by MTT assay	[PMID: 37236376]
PC-3	GI₅₀	102 nM Compound: 10j	Growth inhibition of human PC-3 cells by MTT assay Growth inhibition of human PC-3 cells by MTT assay	[PMID: 37236376]
RPMI-8226	GI₅₀	110 nM Compound: 10j	Growth inhibition of human RPMI-8226 cells by MTT assay Growth inhibition of human RPMI-8226 cells by MTT assay	[PMID: 37236376]
RXF 393	GI₅₀	132 nM Compound: 10j	Growth inhibition of human RXF 393 cells by MTT assay Growth inhibition of human RXF 393 cells by MTT assay	[PMID: 37236376]
SF-268	GI₅₀	813 nM Compound: 10j	Growth inhibition of human SF-268 cells by MTT assay Growth inhibition of human SF-268 cells by MTT assay	[PMID: 37236376]
SF-295	GI₅₀	40 nM Compound: 10j	Growth inhibition of human SF-295 cells by MTT assay Growth inhibition of human SF-295 cells by MTT assay	[PMID: 37236376]
SF-539	GI₅₀	105 nM Compound: 10j	Growth inhibition of human SF-539 cells by MTT assay Growth inhibition of human SF-539 cells by MTT assay	[PMID: 37236376]
SK-MEL-2	GI₅₀	229 nM Compound: 10j	Growth inhibition of human SK-MEL-2 cells by MTT assay Growth inhibition of human SK-MEL-2 cells by MTT assay	[PMID: 37236376]
SK-MEL-28	GI₅₀	427 nM Compound: 10j	Growth inhibition of human SK-MEL-28 cells by MTT assay Growth inhibition of human SK-MEL-28 cells by MTT assay	[PMID: 37236376]
SK-MEL-5	GI₅₀	78 nM Compound: 10j	Growth inhibition of human SK-MEL-5 cells by MTT assay Growth inhibition of human SK-MEL-5 cells by MTT assay	[PMID: 37236376]
SK-OV-3	GI₅₀	269 nM Compound: 10j	Growth inhibition of human SK-OV-3 cells by MTT assay Growth inhibition of human SK-OV-3 cells by MTT assay	[PMID: 37236376]
SN12C	GI₅₀	282 nM Compound: 10j	Growth inhibition of human SN12C cells by MTT assay Growth inhibition of human SN12C cells by MTT assay	[PMID: 37236376]
SNB-19	GI₅₀	158 nM Compound: 10j	Growth inhibition of human SNB-19 cells by MTT assay Growth inhibition of human SNB-19 cells by MTT assay	[PMID: 37236376]
SNB-75	GI₅₀	44 nM Compound: 10j	Growth inhibition of human SNB-75 cells by MTT assay Growth inhibition of human SNB-75 cells by MTT assay	[PMID: 37236376]
SR	GI₅₀	22 nM Compound: 10j	Growth inhibition of human SR cells by MTT assay Growth inhibition of human SR cells by MTT assay	[PMID: 37236376]
SW-620	GI₅₀	45 nM Compound: 10j	Growth inhibition of human SW-620 cells by MTT assay Growth inhibition of human SW-620 cells by MTT assay	[PMID: 37236376]
T47D	GI₅₀	60 nM Compound: 10j	Growth inhibition of human T47D cells by MTT assay Growth inhibition of human T47D cells by MTT assay	[PMID: 37236376]
TK-10	GI₅₀	933 nM Compound: 10j	Growth inhibition of human TK-10 cells by MTT assay Growth inhibition of human TK-10 cells by MTT assay	[PMID: 37236376]
U-251	GI₅₀	72 nM Compound: 10j	Growth inhibition of human U-251 cells by MTT assay Growth inhibition of human U-251 cells by MTT assay	[PMID: 37236376]
U-937	EC₅₀	0.6 μM Compound: 10j	Anticancer activity against human U-937 cells assessed as reduction in cell viability by MTT assay Anticancer activity against human U-937 cells assessed as reduction in cell viability by MTT assay	[PMID: 37236376]
UACC-257	GI₅₀	1622 nM Compound: 10j	Growth inhibition of human UACC-257 cells by MTT assay Growth inhibition of human UACC-257 cells by MTT assay	[PMID: 37236376]
UACC-62	GI₅₀	54 nM Compound: 10j	Growth inhibition of human UACC-62 cells by MTT assay Growth inhibition of human UACC-62 cells by MTT assay	[PMID: 37236376]
UO-31	GI₅₀	186 nM Compound: 10j	Growth inhibition of human UO-31 cells by MTT assay Growth inhibition of human UO-31 cells by MTT assay	[PMID: 37236376]

Chemical Information

CAS No. 2640220-51-3
Molecular Weight 379.41
Formula C₂₂H₂₁NO₅
SMILES

COC1=C(OC)C=C(C(C(OC2)=O)=C2C3=CN(C)C4=C3C=CC=C4)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hurysz B, et al. Synthesis, modeling, and biological evaluation of anti-tubulin indole-substituted furanones. Bioorg Med Chem Lett. 2023 Jun 15;90:129347. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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