Tubulin polymerization-IN-42

Cat. No.: HY-155043: Data Sheet Handling Instructions
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Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, is an inhibitor of tubulin polymerization with anti-cancer activity.

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Tubulin polymerization-IN-42 Chemical Structure

CAS No. : 2640220-51-3

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Biological Activity
Purity & Documentation
References
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Description

Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, is an inhibitor of tubulin polymerization with anti-cancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	316 nM Compound: 10j	Growth inhibition of human 786-0 cells by MTT assay Growth inhibition of human 786-0 cells by MTT assay	[PMID: 37236376]
A498	GI₅₀	17 nM Compound: 10j	Growth inhibition of human A498 cells by MTT assay Growth inhibition of human A498 cells by MTT assay	[PMID: 37236376]
A549	GI₅₀	100 nM Compound: 10j	Growth inhibition of human A549 cells by MTT assay Growth inhibition of human A549 cells by MTT assay	[PMID: 37236376]
ACHN	GI₅₀	537 nM Compound: 10j	Growth inhibition of human ACHN cells by MTT assay Growth inhibition of human ACHN cells by MTT assay	[PMID: 37236376]
BT-549	GI₅₀	62 nM Compound: 10j	Growth inhibition of human BT-549 cells by MTT assay Growth inhibition of human BT-549 cells by MTT assay	[PMID: 37236376]
CAKI-1	GI₅₀	52 nM Compound: 10j	Growth inhibition of human CAKI-1 cells by MTT assay Growth inhibition of human CAKI-1 cells by MTT assay	[PMID: 37236376]
CCRF-CEM	GI₅₀	59 nM Compound: 10j	Growth inhibition of human CCRF-CEM cells by MTT assay Growth inhibition of human CCRF-CEM cells by MTT assay	[PMID: 37236376]
COLO 205	GI₅₀	65 nM Compound: 10j	Growth inhibition of human COLO 205 cells by MTT assay Growth inhibition of human COLO 205 cells by MTT assay	[PMID: 37236376]
DU-145	GI₅₀	209 nM Compound: 10j	Growth inhibition of human DU-145 cells by MTT assay Growth inhibition of human DU-145 cells by MTT assay	[PMID: 37236376]
EKVX	GI₅₀	151 nM Compound: 10j	Growth inhibition of human EKVX cells by MTT assay Growth inhibition of human EKVX cells by MTT assay	[PMID: 37236376]
HCC 2998	GI₅₀	219 nM Compound: 10j	Growth inhibition of human HCC 2998 cells by MTT assay Growth inhibition of human HCC 2998 cells by MTT assay	[PMID: 37236376]
HCT-116	GI₅₀	40 nM Compound: 10j	Growth inhibition of human HCT-116 cells by MTT assay Growth inhibition of human HCT-116 cells by MTT assay	[PMID: 37236376]
HCT-15	GI₅₀	43 nM Compound: 10j	Growth inhibition of human HCT-15 cells by MTT assay Growth inhibition of human HCT-15 cells by MTT assay	[PMID: 37236376]
HL-60	GI₅₀	43 nM Compound: 10j	Growth inhibition of human HL-60 cells by MTT assay Growth inhibition of human HL-60 cells by MTT assay	[PMID: 37236376]
HOP-62	GI₅₀	123 nM Compound: 10j	Growth inhibition of human HOP-62 cells by MTT assay Growth inhibition of human HOP-62 cells by MTT assay	[PMID: 37236376]
HOP-92	GI₅₀	251 nM Compound: 10j	Growth inhibition of human HOP-92 cells by MTT assay Growth inhibition of human HOP-92 cells by MTT assay	[PMID: 37236376]
HT-29	GI₅₀	38 nM Compound: 10j	Growth inhibition of human HT-29 cells by MTT assay Growth inhibition of human HT-29 cells by MTT assay	[PMID: 37236376]
Hs-578T	GI₅₀	158 nM Compound: 10j	Growth inhibition of human Hs-578T cells by MTT assay Growth inhibition of human Hs-578T cells by MTT assay	[PMID: 37236376]
IGROV-1	IC₅₀	76 nM Compound: 10j	Growth inhibition of human IGROV-1 cells by MTT assay Growth inhibition of human IGROV-1 cells by MTT assay	[PMID: 37236376]
K562	GI₅₀	37 nM Compound: 10j	Growth inhibition of human K562 cells by MTT assay Growth inhibition of human K562 cells by MTT assay	[PMID: 37236376]
KM12	GI₅₀	65 nM Compound: 10j	Growth inhibition of human KM12 cells by MTT assay Growth inhibition of human KM12 cells by MTT assay	[PMID: 37236376]
LOX IMVI	GI₅₀	66 nM Compound: 10j	Growth inhibition of human LOX IMVI cells by MTT assay Growth inhibition of human LOX IMVI cells by MTT assay	[PMID: 37236376]
M14	GI₅₀	37 nM Compound: 10j	Growth inhibition of human M14 cells by MTT assay Growth inhibition of human M14 cells by MTT assay	[PMID: 37236376]
MCF7	GI₅₀	28 nM Compound: 10j	Growth inhibition of human MCF7 cells by MTT assay Growth inhibition of human MCF7 cells by MTT assay	[PMID: 37236376]
MDA-MB-231	GI₅₀	339 nM Compound: 10j	Growth inhibition of human MDA-MB-231 cells by MTT assay Growth inhibition of human MDA-MB-231 cells by MTT assay	[PMID: 37236376]
MDA-MB-435	GI₅₀	25 nM Compound: 10j	Growth inhibition of human MDA-MB-435 cells by MTT assay Growth inhibition of human MDA-MB-435 cells by MTT assay	[PMID: 37236376]
MDA-MB-468	GI₅₀	32 nM Compound: 10j	Growth inhibition of human MDA-MB-468 cells by MTT assay Growth inhibition of human MDA-MB-468 cells by MTT assay	[PMID: 37236376]
MOLT-4	GI₅₀	55 nM Compound: 10j	Growth inhibition of human MOLT-4 cells by MTT assay Growth inhibition of human MOLT-4 cells by MTT assay	[PMID: 37236376]
Malme-3M	GI₅₀	195 nM Compound: 10j	Growth inhibition of human Malme-3M cells by MTT assay Growth inhibition of human Malme-3M cells by MTT assay	[PMID: 37236376]
NCI-H226	GI₅₀	692 nM Compound: 10j	Growth inhibition of human NCI-H226 cells by MTT assay Growth inhibition of human NCI-H226 cells by MTT assay	[PMID: 37236376]
NCI-H23	GI₅₀	234 nM Compound: 10j	Growth inhibition of human NCI-H23 cells by MTT assay Growth inhibition of human NCI-H23 cells by MTT assay	[PMID: 37236376]
NCI-H322M	GI₅₀	407 nM Compound: 10j	Growth inhibition of human NCI-H322M cells by MTT assay Growth inhibition of human NCI-H322M cells by MTT assay	[PMID: 37236376]
NCI-H460	GI₅₀	54 nM Compound: 10j	Growth inhibition of human NCI-H460 cells by MTT assay Growth inhibition of human NCI-H460 cells by MTT assay	[PMID: 37236376]
NCI-H522	GI₅₀	49 nM Compound: 10j	Growth inhibition of human NCI-H522 cells by MTT assay Growth inhibition of human NCI-H522 cells by MTT assay	[PMID: 37236376]
NCI/ADR-RES	GI₅₀	47 nM Compound: 10j	Growth inhibition of human NCI/ADR-RES cells by MTT assay Growth inhibition of human NCI/ADR-RES cells by MTT assay	[PMID: 37236376]
OVCAR-3	GI₅₀	36 nM Compound: 10j	Growth inhibition of human OVCAR-3 cells by MTT assay Growth inhibition of human OVCAR-3 cells by MTT assay	[PMID: 37236376]
OVCAR-4	GI₅₀	1259 nM Compound: 10j	Growth inhibition of human OVCAR-4 cells by MTT assay Growth inhibition of human OVCAR-4 cells by MTT assay	[PMID: 37236376]
OVCAR-5	GI₅₀	479 nM Compound: 10j	Growth inhibition of human OVCAR-5 cells by MTT assay Growth inhibition of human OVCAR-5 cells by MTT assay	[PMID: 37236376]
OVCAR-8	GI₅₀	339 nM Compound: 10j	Growth inhibition of human OVCAR-8 cells by MTT assay Growth inhibition of human OVCAR-8 cells by MTT assay	[PMID: 37236376]
PC-3	GI₅₀	102 nM Compound: 10j	Growth inhibition of human PC-3 cells by MTT assay Growth inhibition of human PC-3 cells by MTT assay	[PMID: 37236376]
RPMI-8226	GI₅₀	110 nM Compound: 10j	Growth inhibition of human RPMI-8226 cells by MTT assay Growth inhibition of human RPMI-8226 cells by MTT assay	[PMID: 37236376]
RXF 393	GI₅₀	132 nM Compound: 10j	Growth inhibition of human RXF 393 cells by MTT assay Growth inhibition of human RXF 393 cells by MTT assay	[PMID: 37236376]
SF-268	GI₅₀	813 nM Compound: 10j	Growth inhibition of human SF-268 cells by MTT assay Growth inhibition of human SF-268 cells by MTT assay	[PMID: 37236376]
SF-295	GI₅₀	40 nM Compound: 10j	Growth inhibition of human SF-295 cells by MTT assay Growth inhibition of human SF-295 cells by MTT assay	[PMID: 37236376]
SF-539	GI₅₀	105 nM Compound: 10j	Growth inhibition of human SF-539 cells by MTT assay Growth inhibition of human SF-539 cells by MTT assay	[PMID: 37236376]
SK-MEL-2	GI₅₀	229 nM Compound: 10j	Growth inhibition of human SK-MEL-2 cells by MTT assay Growth inhibition of human SK-MEL-2 cells by MTT assay	[PMID: 37236376]
SK-MEL-28	GI₅₀	427 nM Compound: 10j	Growth inhibition of human SK-MEL-28 cells by MTT assay Growth inhibition of human SK-MEL-28 cells by MTT assay	[PMID: 37236376]
SK-MEL-5	GI₅₀	78 nM Compound: 10j	Growth inhibition of human SK-MEL-5 cells by MTT assay Growth inhibition of human SK-MEL-5 cells by MTT assay	[PMID: 37236376]
SK-OV-3	GI₅₀	269 nM Compound: 10j	Growth inhibition of human SK-OV-3 cells by MTT assay Growth inhibition of human SK-OV-3 cells by MTT assay	[PMID: 37236376]
SN12C	GI₅₀	282 nM Compound: 10j	Growth inhibition of human SN12C cells by MTT assay Growth inhibition of human SN12C cells by MTT assay	[PMID: 37236376]
SNB-19	GI₅₀	158 nM Compound: 10j	Growth inhibition of human SNB-19 cells by MTT assay Growth inhibition of human SNB-19 cells by MTT assay	[PMID: 37236376]
SNB-75	GI₅₀	44 nM Compound: 10j	Growth inhibition of human SNB-75 cells by MTT assay Growth inhibition of human SNB-75 cells by MTT assay	[PMID: 37236376]
SR	GI₅₀	22 nM Compound: 10j	Growth inhibition of human SR cells by MTT assay Growth inhibition of human SR cells by MTT assay	[PMID: 37236376]
SW-620	GI₅₀	45 nM Compound: 10j	Growth inhibition of human SW-620 cells by MTT assay Growth inhibition of human SW-620 cells by MTT assay	[PMID: 37236376]
T47D	GI₅₀	60 nM Compound: 10j	Growth inhibition of human T47D cells by MTT assay Growth inhibition of human T47D cells by MTT assay	[PMID: 37236376]
TK-10	GI₅₀	933 nM Compound: 10j	Growth inhibition of human TK-10 cells by MTT assay Growth inhibition of human TK-10 cells by MTT assay	[PMID: 37236376]
U-251	GI₅₀	72 nM Compound: 10j	Growth inhibition of human U-251 cells by MTT assay Growth inhibition of human U-251 cells by MTT assay	[PMID: 37236376]
U-937	EC₅₀	0.6 μM Compound: 10j	Anticancer activity against human U-937 cells assessed as reduction in cell viability by MTT assay Anticancer activity against human U-937 cells assessed as reduction in cell viability by MTT assay	[PMID: 37236376]
UACC-257	GI₅₀	1622 nM Compound: 10j	Growth inhibition of human UACC-257 cells by MTT assay Growth inhibition of human UACC-257 cells by MTT assay	[PMID: 37236376]
UACC-62	GI₅₀	54 nM Compound: 10j	Growth inhibition of human UACC-62 cells by MTT assay Growth inhibition of human UACC-62 cells by MTT assay	[PMID: 37236376]
UO-31	GI₅₀	186 nM Compound: 10j	Growth inhibition of human UO-31 cells by MTT assay Growth inhibition of human UO-31 cells by MTT assay	[PMID: 37236376]

Molecular Weight

379.41

Formula

C₂₂H₂₁NO₅

CAS No.

2640220-51-3

SMILES

COC1=C(OC)C=C(C(C(OC2)=O)=C2C3=CN(C)C4=C3C=CC=C4)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hurysz B, et al. Synthesis, modeling, and biological evaluation of anti-tubulin indole-substituted furanones. Bioorg Med Chem Lett. 2023 Jun 15;90:129347. [Content Brief]