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Cat. No.: HY-143446

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Tubulin polymerization-IN-7

Tubulin polymerization-IN-7 (compound 5) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-7 has the potential for the research of cancer diseases.

For research use only. We do not sell to patients.

CAS No.: 1394017-46-9
Formula: C₂₈H₂₄N₄O₆S
Molecular Weight:544.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Tubulin polymerization-IN-7 Chemical Structure

CAS No.: 1394017-46-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tubulin polymerization-IN-7 (compound 5) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-7 has the potential for the research of cancer diseases^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.76 μM Compound: 37	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22809558]
HCT-116	IC₅₀	>100 μM Compound: 5	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HEK293	IC₅₀	>100 μM Compound: 5	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HeLa	IC₅₀	16.19 μM Compound: 5	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HepG2	IC₅₀	9.44 μM Compound: 37	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22809558]
HepG2	IC₅₀	9.44 μM Compound: 5	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HT-29	IC₅₀	76.4 μM Compound: 5	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
MKN-45	IC₅₀	9.62 μM Compound: 37	Cytotoxicity against human MKN45 cells after 48 hrs by MTT assay Cytotoxicity against human MKN45 cells after 48 hrs by MTT assay	[PMID: 22809558]
PC-3M	IC₅₀	11.71 μM Compound: 37	Cytotoxicity against human PC3M cells after 48 hrs by MTT assay Cytotoxicity against human PC3M cells after 48 hrs by MTT assay	[PMID: 22809558]

Chemical Information

CAS No. 1394017-46-9
Molecular Weight 544.58
Formula C₂₈H₂₄N₄O₆S
SMILES

O=C1N(N2C(SCC(C3=CC=C(C)C=C3)=O)=NN=C2C4=CC(OC)=C(OC)C(OC)=C4)C(C5=C1C=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen L, et al. Concise synthesis and preliminary biological evaluation of new triazolylthioacetone derivatives bearing pyridine, pyrazine, and 3,4,5-trimethoxybenzyl fragment. Bioorg Med Chem Lett. 2022;66:128721. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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