Tubulin polymerization-IN-74
Based on 1 Customer Validation
Tubulin polymerization-IN-74 (compound 11) is a Tubulin polymerization inhibitor, with IC50 of 15 μM. Tubulin polymerization-IN-74 can be used in anticancer research.
For research use only. We do not sell to patients.
- Purity: 98.79%
- CAS No.: 54491-43-9
- Formula: C14H11NS
- Molecular Weight:225.31
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
>2500 nM
Compound: 11
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Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs
Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs
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[PMID: 15566282] |
Chemical Information
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CAS No. 54491-43-9
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Appearance Solid
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Molecular Weight 225.31
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Formula C14H11NS
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Color White to off-white
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SMILES
C1(SC2=CNC3=C2C=CC=C3)=CC=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL (221.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4383 mL | 22.1916 mL | 44.3833 mL | 110.9582 mL |
| 5 mM | 0.8877 mL | 4.4383 mL | 8.8767 mL | 22.1916 mL | |
| 10 mM | 0.4438 mL | 2.2192 mL | 4.4383 mL | 11.0958 mL | |
| 15 mM | 0.2959 mL | 1.4794 mL | 2.9589 mL | 7.3972 mL | |
| 20 mM | 0.2219 mL | 1.1096 mL | 2.2192 mL | 5.5479 mL | |
| 25 mM | 0.1775 mL | 0.8877 mL | 1.7753 mL | 4.4383 mL | |
| 30 mM | 0.1479 mL | 0.7397 mL | 1.4794 mL | 3.6986 mL | |
| 40 mM | 0.1110 mL | 0.5548 mL | 1.1096 mL | 2.7740 mL | |
| 50 mM | 0.0888 mL | 0.4438 mL | 0.8877 mL | 2.2192 mL | |
| 60 mM | 0.0740 mL | 0.3699 mL | 0.7397 mL | 1.8493 mL | |
| 80 mM | 0.0555 mL | 0.2774 mL | 0.5548 mL | 1.3870 mL | |
| 100 mM | 0.0444 mL | 0.2219 mL | 0.4438 mL | 1.1096 mL |
Tubulin polymerization-IN-74 Related Classifications
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