Viral polymerase-IN-1 hydrochloride
Viral polymerase-IN-1 hydrochloride, a Gemcitabine (HY-17026) derivative, potently inhibits influenza A and B viruses infection with IC90 values of 11.4-15.9 μM. Viral polymerase-IN-1 hydrochloride is active against SARS-CoV-2 infection. Viral polymerase-IN-1 hydrochloride suppresses influenza virus infection by affecting viral RNA replication/transcription in cells.
For research use only. We do not sell to patients.
- CAS No.: 2367587-02-6
- Formula: C15H16ClF2N5O5
- Molecular Weight:419.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 6.4 μM (H1N1) and 5.0 μM (H1N1)[1]
Viral polymerase-IN-1 hydrochloride (compound 2h; 0.1, 1, 10 μM; overnight) reduces viral NP protein expression and viral RNA copies in a dose-dependent manner[1].
Viral polymerase-IN-1 hydrochloride (11, 33, 100 μM, 72 h) potently inhibits viral polymerase activity in a dose-dependent manner on the polymerase activity of influenza A virus PR8 in human cells, HeLa[1].
Viral polymerase-IN-1 hydrochloride efficiently inhibits SARS-CoV-2 infection with an EC50 value of 0.46 μM and a CC50 value above 100 μM, resulting in an SI value of >217.4 in Calu-3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDCK cells infected PR8 virus
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Concentration:0.1, 1, 10 μM
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Incubation Time:Overnight
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Result:Reduced viral NP protein expression and viral RNA copies in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old BALB/c female mice intranasal infection with maPR8[1]
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Dosage:5 mg/kg
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Administration:IP; once daily for 5 days, beginning 4 h prior to virus infection
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Result:Alleviated lung damage or reduced viral RNA replication.
Chemical Information
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CAS No. 2367587-02-6
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Molecular Weight 419.77
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Formula C15H16ClF2N5O5
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SMILES
OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C=CC(NC(C3=NC=C(N)C=C3)=O)=NC2=O)O1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Viral polymerase-IN-1 hydrochloride Related Classifications
HY-149050 Related Classifications
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