WM-586

Art. -Nr.: HY-153728 Reinheit: 98.74% ee.: 99.72%: Data Sheet
COA

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WM-586 is a covalent WDR5 inhibitor. WM-586 specifically decreases WDR5 and MYC interaction with an IC₅₀ of 101 nM. WM-586 is used in research on a variety of cancers including neuroblastoma, breast cancer, bladder cancer and colorectal cancer.

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WM-586 Chemische Struktur

CAS. Nr. : 2894832-05-2

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of WM-586:

(R)-WM-586 In-stock

1 Publications Citing Use of MCE WM-586

•bioRxiv. 2026 Jan 23:2026.01.22.701194. [Abstract]

Spezialitätsempfehlungen

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Beschreibung	WM-586 is a covalent WDR5 inhibitor. WM-586 specifically decreases WDR5 and MYC interaction with an IC₅₀ of 101 nM. WM-586 is used in research on a variety of cancers including neuroblastoma, breast cancer, bladder cancer and colorectal cancer^[1].
IC₅₀ & Target	IC50: 101 nM (WDR5 and MYC interaction)^[1]
In Vitro	WM-586 specifically reduces the interaction between WDR5 and MYC with an IC₅₀ of 101 nM^[1]. WM-586 (0.5-30 μM) does not affect the binding of WDR5 to RBBP5^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. WM-586 Related Antibodies
Molekulargewicht	467.46
Formel	C₂₀H₂₀F₃N₅O₃S
CAS. Nr.	2894832-05-2
Appearance	Solid
Color	White to light yellow
SMILES	FC1=C(C[C@H](CCCC)C(NC2=NN=NN2)=O)C(F)=CC(C3=CC(S(F)(=O)=O)=CC=C3)=C1
Versand	Room temperature in continental US; may vary elsewhere.
Speicherung	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Reinheit & Dokumentation	Purity: 98.74% ee.: 99.72% Select Batch: Data Sheet (268 KB) SDS (252 KB) COA (250 KB) HNMR (173 KB) RP-HPLC (272 KB) NP-HPLC (101 KB) LCMS (97 KB) Handling Instructions (2659 KB)
Verweise	[1]. Ding J, et al. Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. ACS Chem Biol. 2023 Jan 20;18(1):34-40. [Content Brief]

WM-586 Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WM-5862894832-05-2WM586WM 586WDR5WD repeat protein-5WD40 repeat domain protein 5HEK293TWM-662HTRFneuroblastomabreast cancerbladder cancercolorectal cancerInhibitorinhibitorinhibit

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WM-586

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Other Forms of WM-586:

WM-586 Related Antibodies

1 Publications Citing Use of MCE WM-586

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

WM-586 Related Antibodies

WM-586 Related Classifications

Molaritätsrechner

Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

The dilution calculator equation

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

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