Yck2-IN-1

Cat. No.: HY-168998: Ficha de datos Instrucciones de manejo
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Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC₅₀ of approximately 80 nM against Yck2 and a MIC₈₀ of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection.

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Yck2-IN-1 Estructura química

No. CAS : 401816-26-0

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Descripciòn	Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC₅₀ of approximately 80 nM against Yck2 and a MIC₈₀ of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection^[1].
Peso molecular	314.32
Fòrmula	C₁₉H₁₁FN₄
No. CAS	401816-26-0
SMILES	N#CC1=CN2N=C(C(C3=CC=NC=C3)=C2C=C1)C4=CC=C(C=C4)F
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (268 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Puumala E, et al. Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nat Commun. 2025 Mar 4;16(1):2156. [Content Brief]

Yck2-IN-1 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yck2-IN-1401816-26-0FungalCasein KinaseInhibitorinhibitorinhibit

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Yck2-IN-1

Yck2-IN-1 Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Casein Kinase:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Yck2-IN-1 Related Classifications

Calculadora de molaridad

Calculadora de dilución