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Cat. No.: HY-123368

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Zolertine hydrochloride

Zolertine hydrochloride is an α-adrenoceptor antagonist with a pK_i of 6.81 in rat liver (α_1B-adrenoceptors) and 6.35 in rabbit liver (α_1A-adrenoceptors) membranes.

For research use only. We do not sell to patients.

CAS No.: 7241-94-3
Formula: C₁₃H₁₉ClN₆
Molecular Weight:294.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Zolertine hydrochloride Chemical Structure

CAS No.: 7241-94-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Zolertine hydrochloride is an α-adrenoceptor antagonist with a pK_i of 6.81 in rat liver (α_1B-adrenoceptors) and 6.35 in rabbit liver (α_1A-adrenoceptors) membranes^[1].

IC₅₀ & Target

^[1]

α1A-adrenergic receptor

6.35 (pKi, in rabbit liver membrane)

α1B-adrenergic receptor

6.81 (pKi, in rat liver membrane)

All Adrenergic Receptor Isoforms :

In Vitro

The contractile responses induced by noradrenaline are competitively antagonized by Zolertine hydrochloride in rat carotid and aorta arteries, yielding pA₂ values of WKY, 7.48±0.18; SHR, 7.43±0.13 and WKY, 7.57±0.24; SHR, 7.40±0.08, respectively. Zolertine hydrochloride is a non-competitive antagonist in some blood vessels as Schild plot slopes are lower than unity. The pK_b estimates for Zolertine hydrochloride are WKY, 6.98±0.16; SHR, 6.81±0.18 in the mesenteric artery, WKY, 5.73±0.11; SHR, 5.87±0.25 in the caudal artery and 6.65±0.09 in rabbit aorta^[1].
Zolertine hydrochloride shows higher affinity for α_1D-adrenoceptors compared toα_1A-adrenoceptors, while it had an intermediate affinity for α_1B-adrenoceptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 7241-94-3
Molecular Weight 294.78
Formula C₁₃H₁₉ClN₆
SMILES

[H]Cl.N1(CCN(CC1)CCC2=NN=NN2)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ibarra M, et al. The alpha-adrenoceptor antagonist, zolertine, inhibits alpha1D- and alpha1A-adrenoceptor-mediated vasoconstriction in vitro. J Auton Pharmacol. 2000 Jun;20(3):139-45. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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