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Art. -Nr.: HY-159500A

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Zopocianine sodium

(Synonyms: OTL-0078 sodium; OTL78 sodium)

Zopocianine sodium (OTL-0078 sodium; OTL78 sodium) is a near-infrared optical probe targeting PSMA. Zopocianine sodium binds to PSMA on the surface of PSMA-expressing cells, enters cells via receptor-mediated endocytosis, and accumulates in acidic endosomes. Zopocianine sodium selectively accumulates in PSMA-positive cancer tissues and enables the detection of small tumors, primary prostate tumors, and locoregional metastases. Zopocianine sodium helps achieve negative tumor surgical margins during fluorescence-guided surgery. Zopocianine sodium is applicable to research related to prostate cancer.

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CAS. Nr.: 2206660-95-7
Formel: C₇₄H₉₂N₇NaO₂₇S₄
Molecular Weight:1662.80

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Zopocianine sodium Chemical Structure

CAS. Nr.: 2206660-95-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Zopocianine (0.001 nM/L-10 μmol/L; 30 min at 4°C) sodium competes for PSMA binding on 22Rv1 human prostate cancer cells with an IC₅₀ of 7 nM/L^[1].
Zopocianine (0-120 nM/L; 30 min at 4°C) sodium binds directly to PSMA⁺ 22Rv1 human prostate cancer cells with a K_d of 4.7 nmol/L, and shows no significant binding to PSMA^- PC3 human prostate cancer cells^[1].
Zopocianine (100 nM/L; 1 h at 37°C, 1 h at 4°C) sodium binds to the cell surface of PSMA⁺ 22Rv1 and LNCaP human prostate cancer cells at 4°C, and undergoes PSMA-mediated internalization into acidic endosomes at 37°C, with no detectable binding to PSMA^- PC3 human prostate cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zopocianine (0.3-120 nM/mouse; intravenous injection; single administration) sodium selectively accumulates in PSMA-expressing subcutaneous prostate cancer xenografts in nude mice and orthotopic prostate cancer xenografts in SCID mice, enabling fluorescence-guided surgery and achieving negative surgical margins in nude mice bearing subcutaneously inoculated prostate cancer xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

nu/nu (nude) (7-week-old, male; subcutaneous xenograft model with 22Rv1 cells)/SCID (7-week-old, male; orthotopic xenograft model with 22Rv1 cells)^[1]
Dosage:

0.3 nM/mouse, 1 nM/mouse, 3 nM/mouse, 10 nM/mouse, 30 nM/mouse, 120 nM/mouse
Administration:

i.v.; single bolus injection
Result:

Provided an excellent tumor-to-background ratio (TBR) and accumulates within orthotopic prostate tumors.
Enabled fluorescence-guided surgery, achieving a 100% tumor-free survival rate at 30 days, with no observed biochemical recurrence.
Generated high-quality tumor images.

Chemical Information

CAS. Nr. 2206660-95-7
Molecular Weight 1662.80
Formel C₇₄H₉₂N₇NaO₂₇S₄
SMILES

O=S(CCCCN1C2=CC=C(C=C2C(/C1=C/C=C3C(OC4=CC=C(C[C@H](NC([C@H](CC5=CC=CC=C5)NC(CCOCCOCCNC(CC[C@H](NC(N[C@@H](CCC(O[Na])=O)C(O)=O)=O)C(O)=O)=O)=O)=O)C(O)=O)C=C4)=C(/C=C\C6=[N+](CCCCS(=O)([O-])=O)C7=CC=C(C=C7C6(C)C)S(=O)(O)=O)CCC/3)(C)C)S(=O)(O)=O)(O)=O
Synonyms

OTL-0078 sodium; OTL78 sodium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kularatne SA, et al. Evaluation of Novel Prostate-Specific Membrane Antigen-Targeted Near-Infrared Imaging Agent for Fluorescence-Guided Surgery of Prostate Cancer. Clin Cancer Res. 2019;25(1):177-187. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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