Zopocianine sodium
Zopocianine sodium (OTL-0078 sodium; OTL78 sodium) is a near-infrared optical probe targeting PSMA. Zopocianine sodium binds to PSMA on the surface of PSMA-expressing cells, enters cells via receptor-mediated endocytosis, and accumulates in acidic endosomes. Zopocianine sodium selectively accumulates in PSMA-positive cancer tissues and enables the detection of small tumors, primary prostate tumors, and locoregional metastases. Zopocianine sodium helps achieve negative tumor surgical margins during fluorescence-guided surgery. Zopocianine sodium is applicable to research related to prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 2206660-95-7
- Formula: C74H92N7NaO27S4
- Molecular Weight:1662.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Zopocianine (0.001 nM/L-10 μmol/L; 30 min at 4°C) sodium competes for PSMA binding on 22Rv1 human prostate cancer cells with an IC50 of 7 nM/L[1].
Zopocianine (0-120 nM/L; 30 min at 4°C) sodium binds directly to PSMA+ 22Rv1 human prostate cancer cells with a Kd of 4.7 nmol/L, and shows no significant binding to PSMA- PC3 human prostate cancer cells[1].
Zopocianine (100 nM/L; 1 h at 37°C, 1 h at 4°C) sodium binds to the cell surface of PSMA+ 22Rv1 and LNCaP human prostate cancer cells at 4°C, and undergoes PSMA-mediated internalization into acidic endosomes at 37°C, with no detectable binding to PSMA- PC3 human prostate cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:nu/nu (nude) (7-week-old, male; subcutaneous xenograft model with 22Rv1 cells)/SCID (7-week-old, male; orthotopic xenograft model with 22Rv1 cells)[1]
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Dosage:0.3 nM/mouse, 1 nM/mouse, 3 nM/mouse, 10 nM/mouse, 30 nM/mouse, 120 nM/mouse
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Administration:i.v.; single bolus injection
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Result:Provided an excellent tumor-to-background ratio (TBR) and accumulates within orthotopic prostate tumors.
Enabled fluorescence-guided surgery, achieving a 100% tumor-free survival rate at 30 days, with no observed biochemical recurrence.
Generated high-quality tumor images.
Chemical Information
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CAS No. 2206660-95-7
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Molecular Weight 1662.80
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Formula C74H92N7NaO27S4
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SMILES
O=S(CCCCN1C2=CC=C(C=C2C(/C1=C/C=C3C(OC4=CC=C(C[C@H](NC([C@H](CC5=CC=CC=C5)NC(CCOCCOCCNC(CC[C@H](NC(N[C@@H](CCC(O[Na])=O)C(O)=O)=O)C(O)=O)=O)=O)=O)C(O)=O)C=C4)=C(/C=C\C6=[N+](CCCCS(=O)([O-])=O)C7=CC=C(C=C7C6(C)C)S(=O)(O)=O)CCC/3)(C)C)S(=O)(O)=O)(O)=O
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Synonyms
OTL-0078 sodium; OTL78 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zopocianine sodium Related Classifications
HY-159500A Related Classifications
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