country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-178363

Copy Link Print Information

α-Amylase-IN-13

α-Amylase-IN-13 is an orally active, selective, brain-penetrant α-amylase inhibitor (IC₅₀ = 0.71 μM). α-Amylase-IN-13 inhibits α-amylase through a mixed type of inhibition mechanism. α-Amylase-IN-13 leads to a significant reduction in blood glucose level in diabetic rats. α-Amylase-IN-13 causes significant histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 can be used for the study of diabetic complications.

For research use only. We do not sell to patients.

CAS No.: 3085413-64-2
Formula: C₁₇H₁₃F₃N₄O₂S₂
Molecular Weight:426.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

α-Amylase-IN-13 Chemical Structure

CAS No.: 3085413-64-2

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

α-Amylase-IN-13 (Compound 5r) (10 mg/kg, oral gavage, once daily for 14 days) can effectively control Streptozotocin (HY-13753)-induced diabetes in rats and reduce complications^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats (200–250 g body weight) after a 12-h fasting period, type 1 diabetes mellitus was induced intraperitoneally by IP injection of streptozotocin (STZ) at a dose of 55 mg/kg^[1].
Dosage:

10 mg/kg
Administration:

Oral gavage, once daily for 14 days
Result:

Exhibited a notable decrease in blood glucose levels, indicating enhanced glycemic control.
Significantly improved the serum levels of urea, creatinine, HbA1c, AST, ALT, and ALP.
Demonstrated remarkable recovery with the mild congestive hepatic sinusoids, significantly reduced lipid droplets, and fewer ballooned hepatocytes.
Showed remarkably reduced signs of pathological tissue damage.
Enhanced the islet cell integrity and function.

Chemical Information

CAS No. 3085413-64-2
Molecular Weight 426.44
Formula C₁₇H₁₃F₃N₄O₂S₂
SMILES

O=C(NC1=CC=C(C(F)(F)F)C=C1)CN(C/2=O)C(SC2=C/C3=NC=CN3C)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ravi A, et al. Synthesis, in vitro and in vivo evaluation, and computational modeling analysis of thioxothiazolidine derivatives as highly potent and selective α-amylase inhibitors. Eur J Med Chem. 2025 Jul 5;291:117584. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote