α-Amylase-IN-13
α-Amylase-IN-13 is an orally active, selective, brain-penetrant α-amylase inhibitor (IC50 = 0.71 μM). α-Amylase-IN-13 inhibits α-amylase through a mixed type of inhibition mechanism. α-Amylase-IN-13 leads to a significant reduction in blood glucose level in diabetic rats. α-Amylase-IN-13 causes significant histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 can be used for the study of diabetic complications.
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- CAS No.: 3085413-64-2
- Formule: C17H13F3N4O2S2
- Masse moléculaire:426.44
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (200–250 g body weight) after a 12-h fasting period, type 1 diabetes mellitus was induced intraperitoneally by IP injection of streptozotocin (STZ) at a dose of 55 mg/kg[1].
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Dosage:10 mg/kg
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Administration:Oral gavage, once daily for 14 days
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Result:Exhibited a notable decrease in blood glucose levels, indicating enhanced glycemic control.
Significantly improved the serum levels of urea, creatinine, HbA1c, AST, ALT, and ALP.
Demonstrated remarkable recovery with the mild congestive hepatic sinusoids, significantly reduced lipid droplets, and fewer ballooned hepatocytes.
Showed remarkably reduced signs of pathological tissue damage.
Enhanced the islet cell integrity and function.
Chemical Information
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CAS No. 3085413-64-2
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Masse moléculaire 426.44
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Formule C17H13F3N4O2S2
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SMILES
O=C(NC1=CC=C(C(F)(F)F)C=C1)CN(C/2=O)C(SC2=C/C3=NC=CN3C)=S
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Amylase-IN-13 Related Classifications
HY-178363 Related Classifications
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