2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. α-Glucosidase-IN-21

α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity.

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α-Glucosidase-IN-21 Chemical Structure

α-Glucosidase-IN-21 Chemical Structure

CAS No. : 321686-01-5

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α-Glucosidase-IN-21 Related Antibodies

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Description

α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity[1].

In Vivo

α-Glucosidase-IN-21 (Compound 2B; 10 and 20 mg/kg; p.o.; daily, for 4 weeks) has anti-diabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1].
α-Glucosidase-IN-21 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].
α-Glucosidase-IN-21 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats (170-200 g), Streptozotocin-induced diabetes model[1]
Dosage: 10 and 20 mg/kg
Administration: Oral administration; daily, for 4 weeks
Result: Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.
Molecular Weight

389.51

Formula

C24H23NO2S
CAS No.
SMILES

CC1=CC=C(C2=NC3=CC=CC=C3SC(C4=CC=C(OC)C(OC)=C4)C2)C=C1
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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α-Glucosidase-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-21321686-01-5Glucosidaseanti-diabeticblood glucoseanti-hyperlipidemicdiabetesInhibitorinhibitorinhibit

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