α-Glucosidase-IN-21
α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity.
For research use only. We do not sell to patients.
- CAS No.: 321686-01-5
- Formula: C24H23NO2S
- Molecular Weight:389.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
α-Glucosidase-IN-21 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].
α-Glucosidase-IN-21 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar albino rats (170-200 g), Streptozotocin-induced diabetes model[1]
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Dosage:10 and 20 mg/kg
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Administration:Oral administration; daily, for 4 weeks
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Result:Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.
Chemical Information
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CAS No. 321686-01-5
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Molecular Weight 389.51
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Formula C24H23NO2S
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SMILES
CC1=CC=C(C2=NC3=CC=CC=C3SC(C4=CC=C(OC)C(OC)=C4)C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Glucosidase-IN-21 Related Classifications
HY-151145 Related Classifications
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