β-catenin-IN-6
Based on 1 Customer Validation
β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model.
For research use only. We do not sell to patients.
- Purity: 98.65%
- CAS No.: 1039731-99-1
- Formula: C22H19ClN6O
- Molecular Weight:418.88
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Stem Cell Signaling Compound Library
HY-L017
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Wnt/Hedgehog/Notch Compound Library
HY-L020
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Differentiation Inducing Compound Library
HY-L038
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Cytoskeleton Compound Library
HY-L060
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Neuroprotective Compound Library
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Anti-Breast Cancer Compound Library
HY-L074
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Transcription Factor-Targeted Library
HY-L090
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Anti-Liver Cancer Compound Library
HY-L101
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Anti-Colorectal Cancer Compound Library
HY-L103
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Anti-Prostate Cancer Compound Library
HY-L124
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Anti-Pulmonary Fibrosis Compound Library
HY-L125
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Cancer Stem Cells Compound Library
HY-L135
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Antihypertensive Compound Library
HY-L145
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Extracellular Vesicles (EVs) Compound Library
HY-L168
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Anti-Ovarian Cancer Compound Library
HY-L173
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MCE Bioactive Compound Library
HY-L001V
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Anti-Gastric Cancer Compound Library
HY-L184
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Anti-Fibrosis Compound Library
HY-L185
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
1739 nM
Compound: 9
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Growth inhibition of human DLD1 cells after 3 days by luminescent cell viability assay
Growth inhibition of human DLD1 cells after 3 days by luminescent cell viability assay
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[PMID: 20025292] |
| HT-29 | IC50 |
1375 nM
Compound: 9
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Growth inhibition of human HT-29 cells after 3 days by luminescent cell viability assay
Growth inhibition of human HT-29 cells after 3 days by luminescent cell viability assay
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[PMID: 20025292] |
| LoVo | IC50 |
1400 nM
Compound: 9
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Growth inhibition of human LoVo cells after 3 days by luminescent cell viability assay
Growth inhibition of human LoVo cells after 3 days by luminescent cell viability assay
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[PMID: 20025292] |
β-catenin-IN-6 (compound 9) (24 h) inhibits in LoVo and HT29 cells with IC50s of 1.4 μM and 1.37 μM, respectively. β-catenin-IN-6 shows cell growth inhibition against several human colorectal cancer lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
β-catenin-IN-6 (18.75 mg/kg; ip; once daily for 7 days) decreases tumor volume in mouse model, without affecting body weight[1].
β-catenin-IN-6 (compound 13) (150 mg/kg; ip; once per week) suppresses xenograft tumor growth in a β-catenin/RK3E mouse model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1039731-99-1
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Appearance Solid
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Molecular Weight 418.88
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Formula C22H19ClN6O
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Color White to off-white
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SMILES
O=C(C1=CN=C(C=C1)Cl)NC2=CC=C(CNC3=C4C=CC=CC4=NC(NC)=N3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (238.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Dehnhardt CM, et al. Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition. J Med Chem. 2010 Jan 28;53(2):897-910. [Content Brief]
[2]. McCoy MA, et al. Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale. J Med Chem. 2022 May 26;65(10):7246-7261. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3873 mL | 11.9366 mL | 23.8732 mL | 59.6830 mL |
| 5 mM | 0.4775 mL | 2.3873 mL | 4.7746 mL | 11.9366 mL | |
| 10 mM | 0.2387 mL | 1.1937 mL | 2.3873 mL | 5.9683 mL | |
| 15 mM | 0.1592 mL | 0.7958 mL | 1.5915 mL | 3.9789 mL | |
| 20 mM | 0.1194 mL | 0.5968 mL | 1.1937 mL | 2.9841 mL | |
| 25 mM | 0.0955 mL | 0.4775 mL | 0.9549 mL | 2.3873 mL | |
| 30 mM | 0.0796 mL | 0.3979 mL | 0.7958 mL | 1.9894 mL | |
| 40 mM | 0.0597 mL | 0.2984 mL | 0.5968 mL | 1.4921 mL | |
| 50 mM | 0.0477 mL | 0.2387 mL | 0.4775 mL | 1.1937 mL | |
| 60 mM | 0.0398 mL | 0.1989 mL | 0.3979 mL | 0.9947 mL | |
| 80 mM | 0.0298 mL | 0.1492 mL | 0.2984 mL | 0.7460 mL | |
| 100 mM | 0.0239 mL | 0.1194 mL | 0.2387 mL | 0.5968 mL |
β-catenin-IN-6 Related Classifications
HY-10834 Related Classifications
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