1039731-99-1
1039731-99-1
Chemical Structure
β-catenin-IN-6
- No. CAS: 1039731-99-1
- Formula:C22H19ClN6O
- Molecular Weight:418.88
IUPAC Name: 6-chloro-N-(4-(((2-(methylamino)quinazolin-4-yl)amino)methyl)phenyl)nicotinamide
InChIKey: PIROHBFQHMKAPE-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(C=C1)Cl)NC2=CC=C(CNC3=C4C=CC=CC4=NC(NC)=N3)C=C2
Biological Activity: β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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β-catenin-IN-6 | 98.13% | β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model. | ||||||||||||||||||||
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β-catenin-IN-6 (Standard) | β-catenin-IN-6 (Standard) is the analytical standard of β-catenin-IN-6 (HY-10834). This product is intended for research and analytical applications. β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model. | |||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.63
HY-138812Antileishmanial agent-28 -
Similarity Score 0.61
HY-15945DBeQ -
Similarity Score 0.58
HY-141649Anticancer agent 251 -
Similarity Score 0.58
HY-147198Antimalarial agent 13 -
Similarity Score 0.58
HY-144805VEGFR-2-IN-18 -
Similarity Score 0.57
HY-148283WAY-309236 -
Similarity Score 0.57
HY-144803VEGFR-2-IN-16 -
Similarity Score 0.55
HY-183150HDAC1-IN-13 -
Similarity Score 0.55
HY-148000sEH inhibitor-6 -
Explore the MedChemAI to find more analogs
References
- [1]. Dehnhardt CM, et al. Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition. J Med Chem. 2010 Jan 28;53(2):897-910. [Content Brief]
- [2]. McCoy MA, et al. Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale. J Med Chem. 2022 May 26;65(10):7246-7261. [Content Brief]
