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Referencia número: HY-144805

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VEGFR-2-IN-18

VEGFR-2-IN-18 (Compound 15d) is a potent VEGFR-2 inhibitor with an IC₅₀ of 60 nM. VEGFR-2-IN-18 induces cell apoptosis. VEGFR-2-IN-18 shows antitumor activities.

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No. CAS: 3033041-38-9
Fòrmula: C₂₀H₁₃ClN₄O₂
Peso molecular:376.80

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

VEGFR-2-IN-18 Chemical Structure

No. CAS: 3033041-38-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

VEGFR-2-IN-18 (Compound 15d) is a potent VEGFR-2 inhibitor with an IC₅₀ of 60 nM. VEGFR-2-IN-18 induces cell apoptosis. VEGFR-2-IN-18 shows antitumor activities^[1].

IC₅₀ & Target

VEGFR2

60 nM (IC₅₀)

Ver todos los productos específicos de isoformas VEGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	24.1 μM Compound: 54	Antitumor activity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Antitumor activity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 37453330]
MCF7	IC₅₀	33.4 μM Compound: 54	Antitumor activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Antitumor activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 37453330]
PC-3	IC₅₀	40.9 μM Compound: 54	Antitumor activity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Antitumor activity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 37453330]

In Vitro

VEGFR-2-IN-18 (Compound 15d) shows antiproliferative activities with IC₅₀ values of 24.10 ± 2.12, 40.90 ± 3.46, 33.40 ± 2.92 and 221.25 ± 2.55 µM against HepG2, PC3, MCF-7 and WI-38 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 3033041-38-9
Peso molecular 376.80
Fòrmula C₂₀H₁₃ClN₄O₂
SMILES

O=C(NC1=CC=C(OC2=C3C=CC=CC3=NC(Cl)=N2)C=C1)C4=CN=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Abdallah AE, et al. Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):573-591. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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