VEGFR-2-IN-18
VEGFR-2-IN-18 (Compound 15d) is a potent VEGFR-2 inhibitor with an IC50 of 60 nM. VEGFR-2-IN-18 induces cell apoptosis. VEGFR-2-IN-18 shows antitumor activities.
For research use only. We do not sell to patients.
- CAS No.: 3033041-38-9
- Formula: C20H13ClN4O2
- Molecular Weight:376.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
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VEGFR2 60 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
24.1 μM
Compound: 54
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Antitumor activity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 37453330] |
| MCF7 | IC50 |
33.4 μM
Compound: 54
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Antitumor activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 37453330] |
| PC-3 | IC50 |
40.9 μM
Compound: 54
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Antitumor activity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 37453330] |
VEGFR-2-IN-18 (Compound 15d) shows antiproliferative activities with IC50 values of 24.10 ± 2.12, 40.90 ± 3.46, 33.40 ± 2.92 and 221.25 ± 2.55 µM against HepG2, PC3, MCF-7 and WI-38 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033041-38-9
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Molecular Weight 376.80
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Formula C20H13ClN4O2
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SMILES
O=C(NC1=CC=C(OC2=C3C=CC=CC3=NC(Cl)=N2)C=C1)C4=CN=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-2-IN-18 Related Classifications
HY-144805 Related Classifications
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