1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. VEGFR
    Apoptosis
  3. VEGFR-2-IN-18

VEGFR-2-IN-18 

Cat. No.: HY-144805
Handling Instructions

VEGFR-2-IN-18 (Compound 15d) is a potent VEGFR-2 inhibitor with an IC50 of 60 nM. VEGFR-2-IN-18 induces cell apoptosis. VEGFR-2-IN-18 shows antitumor activities.

For research use only. We do not sell to patients.

VEGFR-2-IN-18 Chemical Structure

VEGFR-2-IN-18 Chemical Structure

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Description

VEGFR-2-IN-18 (Compound 15d) is a potent VEGFR-2 inhibitor with an IC50 of 60 nM. VEGFR-2-IN-18 induces cell apoptosis. VEGFR-2-IN-18 shows antitumor activities[1].

IC50 & Target

VEGFR2

60 nM (IC50)

In Vitro

VEGFR-2-IN-18 (Compound 15d) shows antiproliferative activities with IC50 values of 24.10 ± 2.12, 40.90 ± 3.46, 33.40 ± 2.92 and 221.25 ± 2.55 µM against HepG2, PC3, MCF-7 and WI-38 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

376.80

Formula

C20H13ClN4O2

SMILES

O=C(NC1=CC=C(OC2=C3C=CC=CC3=NC(Cl)=N2)C=C1)C4=CN=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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VEGFR-2-IN-18
Cat. No.:
HY-144805
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