2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis
  4. VEGFR-2-IN-18

VEGFR-2-IN-18 (Compound 15d) is a potent VEGFR-2 inhibitor with an IC50 of 60 nM. VEGFR-2-IN-18 induces cell apoptosis. VEGFR-2-IN-18 shows antitumor activities.

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VEGFR-2-IN-18

VEGFR-2-IN-18 Chemical Structure

CAS No. : 3033041-38-9

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VEGFR-2-IN-18 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

VEGFR-2-IN-18 (Compound 15d) is a potent VEGFR-2 inhibitor with an IC50 of 60 nM. VEGFR-2-IN-18 induces cell apoptosis. VEGFR-2-IN-18 shows antitumor activities[1].

IC50 & Target

VEGFR2

60 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
24.1 μM
Compound: 54
Antitumor activity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 37453330]
MCF7 IC50
33.4 μM
Compound: 54
Antitumor activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 37453330]
PC-3 IC50
40.9 μM
Compound: 54
Antitumor activity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antitumor activity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 37453330]
In Vitro

VEGFR-2-IN-18 (Compound 15d) shows antiproliferative activities with IC50 values of 24.10 ± 2.12, 40.90 ± 3.46, 33.40 ± 2.92 and 221.25 ± 2.55 µM against HepG2, PC3, MCF-7 and WI-38 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-18 Related Antibodies
Molecular Weight

376.80

Formula

C20H13ClN4O2
CAS No.
SMILES

O=C(NC1=CC=C(OC2=C3C=CC=CC3=NC(Cl)=N2)C=C1)C4=CN=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-183033041-38-9VEGFRApoptosisVascular endothelial growth factor receptorHepG2PC3MCF-7caspase-3BAXP53Bcl-2antitumorInhibitorinhibitorinhibit

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